Dimethadione embryotoxicity in the rat is neither correlated with maternal systemic drug concentrations nor embryonic tissue levels
Ozolinš TR, Weston AD, Perretta A, Thomson JJ, Brown NA. Dimethadione embryotoxicity in the rat is neither correlated with maternal systemic drug concentrations nor embryonic tissue levels. Toxicology And Applied Pharmacology 2015, 289: 89-97. PMID: 26375719, DOI: 10.1016/j.taap.2015.09.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnticonvulsantsDimethadioneDose-Response Relationship, DrugEmbryo Culture TechniquesEmbryo, MammalianEmbryonic DevelopmentFemaleGestational AgePregnancyRatsRats, Sprague-DawleyTrimethadioneConceptsGD 11Tissue concentrationsSystemic concentrationsWhole embryo cultureTissue levelsMaternal serum levelsIncidence of CHDSystemic drug concentrationsGestational day 8Embryonic concentrationsCHD incidenceMaternal serumSerum levelsPregnant ratsSeparate cohortAnticonvulsant trimethadioneDay 8Embryonic outcomeCongenital heartDrug concentrationsDimethadioneDMO concentrationIncidenceDevelopmental outcomesRats