2015
Dimethadione embryotoxicity in the rat is neither correlated with maternal systemic drug concentrations nor embryonic tissue levels
Ozolinš TR, Weston AD, Perretta A, Thomson JJ, Brown NA. Dimethadione embryotoxicity in the rat is neither correlated with maternal systemic drug concentrations nor embryonic tissue levels. Toxicology And Applied Pharmacology 2015, 289: 89-97. PMID: 26375719, DOI: 10.1016/j.taap.2015.09.005.Peer-Reviewed Original ResearchConceptsGD 11Tissue concentrationsSystemic concentrationsWhole embryo cultureTissue levelsMaternal serum levelsIncidence of CHDSystemic drug concentrationsGestational day 8Embryonic concentrationsCHD incidenceMaternal serumSerum levelsPregnant ratsSeparate cohortAnticonvulsant trimethadioneDay 8Embryonic outcomeCongenital heartDrug concentrationsDimethadioneDMO concentrationIncidenceDevelopmental outcomesRats
2011
Not a walk in the park: the ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design
Thomson J, Johnson K, Chapin R, Stedman D, Kumpf S, Ozolinš TR. Not a walk in the park: the ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design. Birth Defects Research Part B Developmental And Reproductive Toxicology 2011, 92: 111-121. PMID: 21370399, DOI: 10.1002/bdrb.20289.Peer-Reviewed Original Research