2023
Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates
Chen B, Ojha D, Toyonaga T, Tong J, Pracitto R, Thomas M, Liu M, Kapinos M, Zhang L, Zheng M, Holden D, Fowles K, Ropchan J, Nabulsi N, De Feyter H, Carson R, Huang Y, Cai Z. Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2081-2099. PMID: 36849748, DOI: 10.1007/s00259-023-06162-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainGlioblastomaPoly(ADP-ribose) Polymerase InhibitorsPositron-Emission TomographyPrimatesRatsTissue DistributionConceptsPositron emission tomographyHealthy nonhuman primatesVolume of distributionDistribution volume ratioBrain kineticsRat glioblastoma modelPreclinical evaluationBrain regionsGlioblastoma modelPET tracersNonhuman primatesTumor-bearing ratsEx vivo biodistributionPET imaging resultsActive clinical trialsTreatment of glioblastomaHigh specific uptakeDynamic PET scansNoninvasive quantificationBrain positron emission tomographyNondisplaceable volumeBrain penetrationLow nonspecific uptakePrognostic informationClinical trials
2018
PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseases
Cai Z, Li S, Matuskey D, Nabulsi N, Huang Y. PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseases. Neuroscience Letters 2018, 691: 44-50. PMID: 30075287, PMCID: PMC6339829, DOI: 10.1016/j.neulet.2018.07.038.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCarbon RadioisotopesFluorine RadioisotopesHumansLigandsMembrane GlycoproteinsMental DisordersNerve Tissue ProteinsPositron-Emission TomographySynapses
2017
PET Imaging for Early Detection of Alzheimer’s Disease From Pathologic to Physiologic Biomarkers
Bao W, Jia H, Finnema S, Cai Z, Carson RE, Huang YH. PET Imaging for Early Detection of Alzheimer’s Disease From Pathologic to Physiologic Biomarkers. PET Clinics 2017, 12: 329-350. PMID: 28576171, DOI: 10.1016/j.cpet.2017.03.001.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloidBiomarkersHumansPositron-Emission TomographyRadiopharmaceuticals