Exploring the Role of Posttranslational Modifications in Spinal and Bulbar Muscular Atrophy
Gogia N, Ni L, Olmos V, Haidery F, Luttik K, Lim J. Exploring the Role of Posttranslational Modifications in Spinal and Bulbar Muscular Atrophy. Frontiers In Molecular Neuroscience 2022, 15: 931301. PMID: 35726299, PMCID: PMC9206542, DOI: 10.3389/fnmol.2022.931301.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBulbar muscular atrophyAR proteinMuscular atrophyBulbar motor neuronsPolymorphic CAG trinucleotide repeatProgressive neuromuscular diseaseMain genetic causeMutant ARMotor neuronsTherapeutic approachesAR functionNeuromuscular diseaseProtective roleDisease pathophysiologyGenetic causeSkeletal muscleDiseaseCAG trinucleotide repeatAtrophySBMACell deathPolyQ tract expansionTractPolyQ disordersPolyglutamine expansionChapter 8 Exploring the role of protein quality control in aging and age-associated neurodegenerative diseases
Gogia N, Olmos V, Haidery F, Luttik K, Tejwani L, Lim J. Chapter 8 Exploring the role of protein quality control in aging and age-associated neurodegenerative diseases. 2022, 139-171. DOI: 10.1016/b978-0-323-90235-9.00012-4.ChaptersPQC systemAge-associated neurodegenerative diseasesAge-related neurodegenerative diseasesProtein quality control systemCell deathNeurodegenerative diseasesProtein quality controlHallmark of agingAlters cellular functionCellular proteomeCellular functionsProtein misfoldingQuality control systemCellular agingBiological processesPostmitotic natureNeuronal cell deathProteinDisease symptomsEfficient clearanceTherapeutic targetCellsDisease conditionsNervous system tissueEffective therapeutics