2004
Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice.
Compton SR, Ball-Goodrich LJ, Johnson LK, Johnson EA, Paturzo FX, Macy JD. Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice. Comparative Medicine 2004, 54: 681-9. PMID: 15679267.Peer-Reviewed Original ResearchConceptsT cell-deficient miceCell-deficient miceMouse hepatitis virusBALB/cGastrointestinal tractC57BL/6 miceLymphoid tissueViral RNASubclinical infectionHepatitis virusInfected B-cell-deficient miceSmall intestineEnterotropic mouse hepatitis virusB cell-deficient miceImmunocompetent BALB/cMost natural infectionsChronic subclinical infectionMultiple organ systemsTranscriptase-polymerase chain reaction analysisImmunocompetent miceLethal infectionEnterotropic strainsT cellsImmunodeficient miceIntestinal mucosa
2003
Pathogenesis of mouse hepatitis virus infection in gamma interferon-deficient mice is modulated by co-infection with Helicobacter hepaticus.
Compton SR, Ball-Goodrich LJ, Zeiss CJ, Johnson LK, Johnson EA, Macy JD. Pathogenesis of mouse hepatitis virus infection in gamma interferon-deficient mice is modulated by co-infection with Helicobacter hepaticus. Comparative Medicine 2003, 53: 197-206. PMID: 12784855.Peer-Reviewed Original ResearchConceptsIFN-gamma KO miceGamma interferon-deficient miceMouse hepatitis virusInterferon-deficient miceDevelopment of peritonitisKO miceH. hepaticusMultisystemic infectionHelicobacter hepaticusMouse hepatitis virus infectionHepatitis virus infectionAberrant immune responseSelf-limiting infectionMinimal pathologic changesMultifocal hepatic necrosisLater time pointsAcute necrotizingAcute peritonitisAcute phaseInflammatory lesionsImmunocompetent miceChronic infectionHepatic necrosisMHV infectionPathologic changes
2002
Assessment of static isolator cages with automatic watering when used with conventional husbandry techniques as a factor in the transmission of mouse hepatitis virus.
Macy JD, Cameron GA, Ellis SL, Hill EA, Compton SR. Assessment of static isolator cages with automatic watering when used with conventional husbandry techniques as a factor in the transmission of mouse hepatitis virus. Journal Of The American Association For Laboratory Animal Science 2002, 41: 30-5. PMID: 12109894.Peer-Reviewed Original ResearchConceptsFilter-top cagesMouse hepatitis virusUninoculated miceHepatitis virusCages of miceTransmission of infectionExamination of fecesLong-term useImmunocompetent miceHigh virus concentrationsPolymerase chain reaction amplificationMiceChain reaction amplificationWeeksStandard cagesMHV-A59Fecal samplesRoutine husbandrySerologyTest cageVirusInfected cagesInfectionReaction amplificationRows of cages