James S. Farrelly, MD, MHS
Assistant Professor of Surgery (General, Trauma & Surgical Critical Care)DownloadHi-Res Photo
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Assistant Professor of Surgery (General, Trauma & Surgical Critical Care)
Appointments
General Surgery, Trauma & Surgical Critical Care
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Surgical Critical Care Fellow
- Yale New Haven Hospital/Yale School of Medicine (2021)
- Resident Physician
- Yale New Haven Hospital/Yale School of Medicine (2020)
- MHS
- Yale University Graduate School of Arts and Sciences (2017)
- Pediatric Surgery Research Fellow
- Yale School of Medicine (2017)
- MD
- State University of New York Downstate Med Ctr., Clinical Neuroscience Pathway, cum laude (2013)
- BA
- Davidson College, Music Major, Chemistry Minor, cum laude (2008)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of James S. Farrelly's published research.
Publications Timeline
A big-picture view of James S. Farrelly's research output by year.
David Stitelman, MD
Basile Njei, MD, MPH, PhD
Emily Christison-Lagay, MD
Francesc Lopez-Giraldez, PhD
Joshua Copel, MD
Michael Caty, MD, MMM
12Publications
280Citations
Publications
2021
Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele
Maassel N, Farrelly J, Coman D, Freedman-Weiss M, Ahle S, Ullrich S, Yung N, Hyder F, Stitelman D. Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele. PLOS ONE 2021, 16: e0253583. PMID: 34191842, PMCID: PMC8244849, DOI: 10.1371/journal.pone.0253583.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMagnetic resonance imaging techniquesSpinal cordRat fetusesRetinoic acidCommon congenital anomalyComplementary imaging biomarkerLack of skinNeural tube defectsTrans retinoic acidBony coveringRat damsCongenital anomaliesRat modelExperimental therapiesHistopathologic analysisSevere formBrain volumeMyelomeningoceleImaging biomarkersDisease severityMMC defectsTube defectsIncomplete closureFetusesFractional anisotropy (FA) mapsEngineering alginate microparticles for optimized accumulation in fetal rat myelomeningocele
Freedman-Weiss MR, Wu D, Maassel N, Ullrich SJ, Ahle SL, Roberts K, Farrelly JS, Buzzelli G, Saltzman WM, Stitelman DH. Engineering alginate microparticles for optimized accumulation in fetal rat myelomeningocele. Journal Of Pediatric Surgery 2021, 57: 544-550. PMID: 33933264, DOI: 10.1016/j.jpedsurg.2021.03.060.Peer-Reviewed Original ResearchCitations
2020
Anomalies of the Gastrointestinal Tract
Rubinstein J, Farrelly J, Stitelman D, Christison-Lagay E. Anomalies of the Gastrointestinal Tract. 2020, 179-204. DOI: 10.1007/978-3-030-55660-0_9.ChaptersRole of Prophylactic Cholecystectomy After Endoscopic Sphincterotomy for Biliary Stone Disease: A Systematic Review and Meta-analysis.
McCarty TR, Farrelly J, Njei B, Jamidar P, Muniraj T. Role of Prophylactic Cholecystectomy After Endoscopic Sphincterotomy for Biliary Stone Disease: A Systematic Review and Meta-analysis. Annals Of Surgery 2020, 273: 667-675. PMID: 32590541, DOI: 10.1097/sla.0000000000003977.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRecurrent biliary painProphylactic cholecystectomyBile duct stonesMeta-AnalysisSystematic reviewBiliary painDuct stonesCommon bile duct stonesBiliary stone diseaseSubset of patientsCochrane Library databasesRisk of mortalityConfidence intervalsRate of pancreatitisPooled effect sizeSearch of PubMedPreferred Reporting ItemsRandom-effects modelWeb of ScienceBiliary complicationsEventual cholecystectomyComplication rateEndoscopic cholangiopancreatographyEndoscopic sphincterotomyBiliary sphincterotomy
2018
Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele
Farrelly JS, Bianchi AH, Ricciardi AS, Buzzelli GL, Ahle SL, Freedman-Weiss MR, Luks VL, Saltzman WM, Stitelman DH. Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele. Journal Of Pediatric Surgery 2018, 54: 80-85. PMID: 30414695, DOI: 10.1016/j.jpedsurg.2018.10.031.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSoft tissue coverageTissue coverageRat modelTime-dated pregnant ratsFree bFGFGrowth factorInjection of microparticlesBasic fibroblast growth factorFibroblast growth factorPregnant ratsPrenatal treatmentIntraamniotic injectionFetal myelomeningoceleMyelomeningoceleMMC coverageMMC defectsRetinoic acidBFGFIn utero nanoparticle delivery for site-specific genome editing
Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. In utero nanoparticle delivery for site-specific genome editing. Nature Communications 2018, 9: 2481. PMID: 29946143, PMCID: PMC6018676, DOI: 10.1038/s41467-018-04894-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSite-specific genome editingReversal of splenomegalyPeptide nucleic acidIntra-amniotic administrationBlood hemoglobin levelsMonogenic disordersNanoparticle deliveryPolymeric nanoparticlesPostnatal elevationGestational ageHemoglobin levelsImproved survivalPediatric morbidityDisease improvementHuman β-thalassemiaReticulocyte countNormal organ developmentMouse modelNormal rangeEarly interventionGenome editingOff-target mutationsPostnatal growthGene editingVersatile methodAn atypical case of megacystis microcolon intestinal hypoperistalsis syndrome with extended survival and consistent bowel function
Farrelly J, Weiss R, Copel J, Porto A, Ahle S, Luks V, McGrath J, Stitelman D. An atypical case of megacystis microcolon intestinal hypoperistalsis syndrome with extended survival and consistent bowel function. Journal Of Pediatric Surgery Case Reports 2018, 30: 48-51. DOI: 10.1016/j.epsc.2017.11.010.Peer-Reviewed Case Reports and Technical NotesCitations
2017
Surgical tray optimization as a simple means to decrease perioperative costs
Farrelly JS, Clemons C, Witkins S, Hall W, Christison-Lagay ER, Ozgediz DE, Cowles RA, Stitelman DH, Caty MG. Surgical tray optimization as a simple means to decrease perioperative costs. Journal Of Surgical Research 2017, 220: 320-326. PMID: 29180198, DOI: 10.1016/j.jss.2017.06.029.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSurgery sectionSingle-site observational studyHealth care cost reductionLarge academic medical centerHospital cost reductionCare cost reductionAcademic medical centerSurgical tray optimizationSurgical traysStudy startHealth care spendingSpine surgeryObservational studySurgical sectionMedical CenterPediatric surgeryPediatric surgeonsPerioperative costsAcademic centersUrology SectionOperating room nursingMultidisciplinary teamPediatric urologyPediatric orthopedicsScrub technicians
2016
Complications in pediatric enteral and vascular access
Farrelly JS, Stitelman DH. Complications in pediatric enteral and vascular access. Seminars In Pediatric Surgery 2016, 25: 371-379. PMID: 27989361, DOI: 10.1053/j.sempedsurg.2016.10.006.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsAcquired seminal vesicle cyst in a teenager with a urethral stricture of unknown etiology
Farrelly J, Cleary M, Weiss R, Morotti R, Stitelman D. Acquired seminal vesicle cyst in a teenager with a urethral stricture of unknown etiology. Journal Of Pediatric Surgery Case Reports 2016, 7: 8-12. DOI: 10.1016/j.epsc.2016.01.002.Peer-Reviewed Original ResearchCitationsConceptsSeminal vesicle cystUrethral strictureUpper urinary tract anatomyUpper urinary tract anomaliesLower urinary tract signsUrinary tract anatomyUrinary tract anomaliesUrinary tract signsUrethral inflammationTract anomaliesTract signsPediatric populationBulbar urethraRare diagnosisUnknown etiologyUrethral pathologyComplete resolutionYounger ageTract anatomyUnique caseCystsStrictureInflammationPatientsUrethra
Clinical Care
Overview
James S. Farrelly, MD specializes in general surgery, trauma, and surgical critical care. He performs a variety of surgical procedures ranging from minor skin procedures to complex abdominal surgeries. Dr. Farrelly is particularly skilled in using the DaVinci robotic system for hernia surgeries.
Dr. Farrelly is not only a surgeon but also an educator and researcher at Yale School of Medicine, where he's making strides in surgical innovation and knowledge sharing. His research interests include a wide range of topics from prostate cancer therapies and bioengineered intrauterine fetal gene therapy to cost-containment of peri-operative surgical materials and process management. He has contributed to numerous publications and presented at multiple national and international academic conferences, sharing his insights and expertise with colleagues and aspiring medical professionals across the globe.
Dr. Farrelly completed his medical education at SUNY Downstate Medical Center, followed by residency at Yale School of Medicine and a fellowship in surgical critical care at Yale New Haven Hospital. He also holds a master’s degree of Health Sciences from Yale University.
Dr. James S. Farrelly is an assistant professor of surgery at Yale School of Medicine.
Clinical Specialties
General Surgery, Trauma & Surgical Critical Care
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