2023
Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia
Li X, Lozovatsky L, Tommasini S, Fretz J, Finberg K. Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia. Blood Advances 2023, 7: 5156-5171. PMID: 37417950, PMCID: PMC10480544, DOI: 10.1182/bloodadvances.2022009524.Peer-Reviewed Original ResearchConceptsSinusoidal endothelial cellsEndothelial cellsBone marrowBM sectionsFGF23 upregulationFibroblast growth factor 23Iron deficiencyElevated serum erythropoietinFGF23 promoter activityBM endothelial cellsGrowth factor 23Vitamin D metabolismIron deficiency anemiaSystemic iron deficiencyKnockout mice exhibitBone marrow sinusoidal endothelial cellsNormal iron balanceNonanemic controlsChronic anemiaFactor 23D metabolismEndothelial cell populationErythropoietin treatmentDeficiency anemiaMouse model
2010
Altered Metabolism and Lipodystrophy in the Early B-Cell Factor 1-Deficient Mouse
Fretz JA, Nelson T, Xi Y, Adams DJ, Rosen CJ, Horowitz MC. Altered Metabolism and Lipodystrophy in the Early B-Cell Factor 1-Deficient Mouse. Endocrinology 2010, 151: 1611-1621. PMID: 20172967, PMCID: PMC2850234, DOI: 10.1210/en.2009-0987.Peer-Reviewed Original ResearchMeSH KeywordsAdiponectinAdipose TissueAnimalsBlood GlucoseBone MarrowCalorimetryCCAAT-Enhancer-Binding Protein-betaEnergy MetabolismGlucagonInsulinLeptinLipid MetabolismLipodystrophyMiceMice, KnockoutPPAR gammaReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStatistics, NonparametricTrans-ActivatorsConceptsSerum glucose levelsWhite adipose tissueMarrow adiposityGlucose levelsAdipose tissueLevels of leptinBone formation rateAdipose tissue depositionNumber of osteoblastsWk of ageAltered bone morphologySerum osteocalcinInsulin levelsGlucose challengeIP injectionPancreatic hormonesLittermate controlsLipid depositionBone marrowSerum analysisBrown adiposeTissue depositionAltered metabolismMiceAdiposity