Bone Marrow Sinusoidal Endothelial Cells Are a Site of Fgf23 Upregulation in Murine ß-Thalassemia
Fretz J, Chua E, Li X, Finberg K. Bone Marrow Sinusoidal Endothelial Cells Are a Site of Fgf23 Upregulation in Murine ß-Thalassemia. Blood 2023, 142: 3851. DOI: 10.1182/blood-2023-190706.Peer-Reviewed Original ResearchFGF23 levelsBone marrowSinusoidal endothelial cellsWeeks of ageBone marrow sinusoidal endothelial cellsFGF23 upregulationPlasma levelsIntact FGF23Ineffective erythropoiesisChronic iron deficiency anemiaFibroblast growth factor 23Endothelial cellsFGF23 null miceFGF23 promoter activitySystemic iron loadingGrowth factor 23Body weight ratioLeft ventricular hypertrophyElevated FGF23 levelsElevated plasma levelsEffects of FGF23Intact FGF23 levelsIron deficiency anemiaSeverity of anemiaStandard rodent diet