Bone Marrow Sinusoidal Endothelial Cells Are a Site of Fgf23 Upregulation in Murine ß-Thalassemia
Fretz J, Chua E, Li X, Finberg K. Bone Marrow Sinusoidal Endothelial Cells Are a Site of Fgf23 Upregulation in Murine ß-Thalassemia. Blood 2023, 142: 3851. DOI: 10.1182/blood-2023-190706.Peer-Reviewed Original ResearchFGF23 levelsBone marrowSinusoidal endothelial cellsWeeks of ageBone marrow sinusoidal endothelial cellsFGF23 upregulationPlasma levelsIntact FGF23Ineffective erythropoiesisChronic iron deficiency anemiaFibroblast growth factor 23Endothelial cellsFGF23 null miceFGF23 promoter activitySystemic iron loadingGrowth factor 23Body weight ratioLeft ventricular hypertrophyElevated FGF23 levelsElevated plasma levelsEffects of FGF23Intact FGF23 levelsIron deficiency anemiaSeverity of anemiaStandard rodent dietBone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia
Li X, Lozovatsky L, Tommasini S, Fretz J, Finberg K. Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia. Blood Advances 2023, 7: 5156-5171. PMID: 37417950, PMCID: PMC10480544, DOI: 10.1182/bloodadvances.2022009524.Peer-Reviewed Original ResearchConceptsSinusoidal endothelial cellsEndothelial cellsBone marrowBM sectionsFGF23 upregulationFibroblast growth factor 23Iron deficiencyElevated serum erythropoietinFGF23 promoter activityBM endothelial cellsGrowth factor 23Vitamin D metabolismIron deficiency anemiaSystemic iron deficiencyKnockout mice exhibitBone marrow sinusoidal endothelial cellsNormal iron balanceNonanemic controlsChronic anemiaFactor 23D metabolismEndothelial cell populationErythropoietin treatmentDeficiency anemiaMouse model