2023
Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments
Krystal J, Kaye A, Jefferson S, Girgenti M, Wilkinson S, Sanacora G, Esterlis I. Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2305772120. PMID: 38011560, PMCID: PMC10710048, DOI: 10.1073/pnas.2305772120.Peer-Reviewed Original Research
2022
Imaging the effect of ketamine on synaptic density (SV2A) in the living brain
Holmes SE, Finnema SJ, Naganawa M, DellaGioia N, Holden D, Fowles K, Davis M, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Imaging the effect of ketamine on synaptic density (SV2A) in the living brain. Molecular Psychiatry 2022, 27: 2273-2281. PMID: 35165397, PMCID: PMC9133063, DOI: 10.1038/s41380-022-01465-2.Peer-Reviewed Original ResearchConceptsKetamine's therapeutic effectsMajor depressive disorderTherapeutic effectPositron emission tomographyPosttraumatic stress disorderHealthy controlsSynaptic connectionsSynaptic vesicle protein 2APost-synaptic mechanismsEffects of ketamineDiscovery of ketamineNon-human primatesAntidepressant effectsDepressive disorderSingle administrationSynaptic densityPsychiatric disordersDepression severityKetamineEmission tomographyTerminal densityLiving brainStress disorderRobust reductionDissociative symptoms
2021
Acute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder
Davis MT, DellaGiogia N, Maruff P, Pietrzak RH, Esterlis I. Acute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder. Translational Psychiatry 2021, 11: 205. PMID: 33833217, PMCID: PMC8032778, DOI: 10.1038/s41398-021-01327-5.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsCognitionDepressive Disorder, MajorHumansKetamineStress Disorders, Post-TraumaticConceptsPosttraumatic stress disorderExecutive functionStress disorderCognitive functionSingle-dose intravenous ketamineAcute cognitive effectsLarge magnitude improvementsPTSD relativeCognitive measuresCognitive domainsPTSD individualsMemory performanceCognitive effectsYears of educationBaseline performanceCognitive declineHealthy controlsPsychiatric distressCognitive dysfunctionHC individualsHC groupDepressive symptomsMemory 2Subanesthetic doseMajor depressive