2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity
Lou B, Liu Q, Hou J, Kabir I, Liu P, Ding T, Dong J, Mo M, Ye D, Chen Y, Bui HH, Roth K, Cao Y, Jiang XC. 2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity. Journal Of Biological Chemistry 2018, 293: 18328-18336. PMID: 30305392, PMCID: PMC6254338, DOI: 10.1074/jbc.ra118.005904.Peer-Reviewed Original ResearchConceptsSMS activationAnticancer effectsCancer cell cycle arrestU118 cellsDose-dependent fashionSM activityPlasma phosphatidylcholinePredictive biomarkersTumor responseC57BL/6J miceCell cycle arrestTotal cellular phosphatidylcholinePotent anticancer drugLysophosphatidylcholine acyltransferase activitySphingomyelin levelsCancer cellsPhosphatidylcholine metabolismTissue homogenatesSphingomyelin accumulationCycle arrestSphingomyelin synthase activityMouse tissue homogenatesAnticancer propertiesCancer suppressionAcyltransferase activity