2022
DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion
Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, Ye Y, Zhan M, Cai W, Li H, Li HB. DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nature Communications 2022, 13: 2059. PMID: 35440133, PMCID: PMC9018773, DOI: 10.1038/s41467-022-29754-y.Peer-Reviewed Original ResearchConceptsPD-L1 expressionTumor immune evasionImmune evasionReduced PD-L1 expressionDeath ligand 1Tumor-killing activityT cellsTherapeutic targetTumor growthCancer cellsCRISPR/Cas9 screeningLigand 1Cell homeostasisKinase 2ExpressionEvasionCD8ImmunotherapyCellsIFNγDysfunctionRBP dysfunctionTumorsCancer
2021
METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells
Song H, Song J, Cheng M, Zheng M, Wang T, Tian S, Flavell RA, Zhu S, Li HB, Ding C, Wei H, Sun R, Peng H, Tian Z. METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells. Nature Communications 2021, 12: 5522. PMID: 34535671, PMCID: PMC8448775, DOI: 10.1038/s41467-021-25803-0.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAnimalsCarcinogenesisCell Line, TumorGene DeletionHomeostasisInterleukin-15Killer Cells, NaturalLymphocytes, Tumor-InfiltratingMethylationMethyltransferasesMice, Inbred C57BLMice, KnockoutNeoplasmsProtein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene Proteins c-aktRNASignal TransductionTumor MicroenvironmentConceptsAnti-tumor immunityNK cellsTumor-infiltrating NK cellsNK cell infiltrationNatural killer cellsAccelerated tumor developmentExert critical rolesImmunosurveillance functionKiller cellsIL-15Cell infiltrationTumor microenvironmentTumor developmentProtein expressionSuppressed activationM6A RNA methylationEffector moleculesExpression levelsMETTL3Cells altersImmunityM6A methylationCellsPositive correlationHomeostasis
2020
A special collection of reviews on frontiers in immunology
Xu C, Li HB, Flavell RA. A special collection of reviews on frontiers in immunology. Cell Research 2020, 30: 827-828. PMID: 32859992, PMCID: PMC7454546, DOI: 10.1038/s41422-020-00403-7.Peer-Reviewed Original Research
2018
RNA m6A modification and its function in diseases
Tong J, Flavell RA, Li HB. RNA m6A modification and its function in diseases. Frontiers Of Medicine 2018, 12: 481-489. PMID: 30097961, DOI: 10.1007/s11684-018-0654-8.Peer-Reviewed Original ResearchConceptsM6A modificationPost-transcriptional RNA modificationsRegulation of m6ACore catalytic componentFunction of m6ARNA m6A modificationRNA metabolismRegulatory networksRNA modificationsPhysiological contextHuman diseasesPhysiological roleM6ACatalytic componentFunctional relevanceCell linesM6A modulatorsDifferent cellsDisease conditionsTranscriptomeRecent advancesErasersRegulatorBindsModification