2020
A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing
Dash BC, Setia O, Gorecka J, Peyvandi H, Duan K, Lopes L, Nie J, Berthiaume F, Dardik A, Hsia HC. A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing. Cells 2020, 9: 966. PMID: 32295218, PMCID: PMC7226960, DOI: 10.3390/cells9040966.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsSecretory functionHuman-induced pluripotent stem cellsParacrine secretionMuscle cellsCollagen fibrillar densitiesSecretory factorsVascular regenerationWound healingTissue-engineered vascular graftsHealingVascular graftsStem cellsPluripotent stem cellsCollagen scaffoldsScaffold propertiesScaffold materialsCellsPromising strategyDisease modelingFibrillar densityRegenerative wound healingCytokinesGraftInduced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing
Gorecka J, Gao X, Fereydooni A, Dash BC, Luo J, Lee SR, Taniguchi R, Hsia HC, Qyang Y, Dardik A. Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing. Regenerative Medicine 2020, 15: 1277-1293. PMID: 32228292, PMCID: PMC7304438, DOI: 10.2217/rme-2019-0086.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsMuscle cellsDiabetic wound healingWound healingPro-angiogenic cytokinesMurine AdiposeStem cellsType macrophagesCollagen scaffoldsCultured mediumM2-type macrophagesCellsNumber of totalNew candidatesAngiogenesisNude miceDiabetic woundsPromising new candidateScaffoldsHealingCytokinesExpressionSecreteWoundsAdipose
2011
The Fiber Diameter of Synthetic Bioresorbable Extracellular Matrix Influences Human Fibroblast Morphology and Fibronectin Matrix Assembly
Hsia HC, Nair MR, Mintz RC, Corbett SA. The Fiber Diameter of Synthetic Bioresorbable Extracellular Matrix Influences Human Fibroblast Morphology and Fibronectin Matrix Assembly. Plastic & Reconstructive Surgery 2011, 127: 2312-2320. PMID: 21617465, PMCID: PMC3103705, DOI: 10.1097/prs.0b013e3182139fa4.Peer-Reviewed Original ResearchConceptsFibronectin matrix assemblyMatrix assemblyActin cytoskeletal morphologyFocal adhesion complexesFocal adhesion sizeActin stress fibersCell proliferationAdhesion complexesAdhesion sizeEnvironmental cuesStress fibersCellular responsesAbility of scaffoldsCytoskeletal morphologyScaffold fiber diameterHuman dermal fibroblastsFibril formationCell functionImmunofluorescent microscopyBiological responsesMicrofiber scaffoldsFibroblast morphologyDermal fibroblastsHigher cell proliferationCells