2013
Identification of Functionally Distinct Na-HCO3 Co-Transporters in Colon
Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM. Identification of Functionally Distinct Na-HCO3 Co-Transporters in Colon. PLOS ONE 2013, 8: e62864. PMID: 23690961, PMCID: PMC3653958, DOI: 10.1371/journal.pone.0062864.Peer-Reviewed Original ResearchConceptsNa-HCO3 cotransportDistal colonProximal colonNBC activityNBC isoformsRat colonColonic epithelial cellsCrypt glandsSensitive transporterHCO3- secretionColonHCO3-dependent mechanismEpithelial cellsSaturable processHOE694Isoform 1Basolateral membraneCotransportPCR analysisNorthern blotDIDSMolecular studiesMolecular identityApparent KiCritical role
1994
Differential modulation of Na-HCO3 cotransport and Na-H exchange by pH in basolateral membrane vesicles of rat distal colon.
Rajendran V, Binder H. Differential modulation of Na-HCO3 cotransport and Na-H exchange by pH in basolateral membrane vesicles of rat distal colon. Journal Of Biological Chemistry 1994, 269: 156-160. PMID: 8276790, DOI: 10.1016/s0021-9258(17)42328-3.Peer-Reviewed Original ResearchConceptsMembrane vesiclesDifferent cellular functionsBasolateral membrane vesiclesProton concentration gradientCellular functionsIntravesicular protonsApparent KmVesiclesTransport systemNa-H exchangeCotransportDifferential modulationHigh proton concentrationProton concentrationProton stimulationNa-HCO3 cotransportConcentration gradientKmRat distal colonProteinSeparate mechanismsVmax