2024
A Smartphone App-Based Mindfulness Intervention to Enhance Recovery from Substance Use Disorders: Protocol for a Pilot Feasibility Randomized Controlled Trial
Roos C, Bricker J, Kiluk B, Trull T, Bowen S, Witkiewitz K, Kober H. A Smartphone App-Based Mindfulness Intervention to Enhance Recovery from Substance Use Disorders: Protocol for a Pilot Feasibility Randomized Controlled Trial. Contemporary Clinical Trials Communications 2024, 101338. DOI: 10.1016/j.conctc.2024.101338.Peer-Reviewed Original ResearchTreatment-as-usualSubstance use disordersRecovery outcomesLong-term recovery outcomesFeasibility of study proceduresFeasibility randomized controlled trialMindfulness-based treatmentsUse disorderRandomized controlled trialsEcological momentary assessmentIn-personMindfulness interventionPilot trialStudy proceduresControlled trialsMomentary assessmentPublic healthEnhanced recoveryOutpatient treatmentMechanical variablesOutcomesTrialsAppsDelivery methodsIndividualsBack to Normal? Harnessing Long Short-term Memory Network to Examine the Associations Between Adolescent Social Interactions and Depressive Symptoms During Different Stages of COVID-19
Polack R, Zhang A, Kober H, Joormann J, Benisty H. Back to Normal? Harnessing Long Short-term Memory Network to Examine the Associations Between Adolescent Social Interactions and Depressive Symptoms During Different Stages of COVID-19. Research On Child And Adolescent Psychopathology 2024, 1-13. PMID: 38922462, DOI: 10.1007/s10802-024-01208-7.Peer-Reviewed Original ResearchDepressive symptomsSocial interactionMental healthPredicting depressive symptomsDaily social interactionsAdolescent social interactionsAdolescents' social environmentAge differencesDevelopmental periodAdolescentsSymptomsSocial environmentPre-pandemic patternsSocial influenceMemory networkStages of COVID-19Seventy-nineChronic stageLong-short term memory recurrent networkYouthDepressionDiaryCOVID-19AssociationIt's a balancing act: The ratio of maladaptive (vs. All) emotion regulation strategies is associated with depression
Gadassi-Polack R, Paganini G, Zhang A, Dworschak C, Silk J, Kober H, Joormann J. It's a balancing act: The ratio of maladaptive (vs. All) emotion regulation strategies is associated with depression. Behaviour Research And Therapy 2024, 180: 104600. PMID: 38950508, DOI: 10.1016/j.brat.2024.104600.Peer-Reviewed Original ResearchEmotion regulationER repertoireER flexibilityER strategiesAssociated with psychopathologyMaladaptive emotion regulationEmotion regulation strategiesAssociated with depressive symptomsAssociated with depressionYears of adolescenceDaily-diaryAtypical developmentDepressive symptomsRegulation strategiesDevelopmental periodDepressionPsychopathologyEmotionsAdolescentsYouthYear levelSymptomsResearchNeuromarkers in addiction: definitions, development strategies, and recent advances
Harp N, Wager T, Kober H. Neuromarkers in addiction: definitions, development strategies, and recent advances. Journal Of Neural Transmission 2024, 131: 509-523. PMID: 38630190, DOI: 10.1007/s00702-024-02766-2.Peer-Reviewed Original ResearchConceptsSubstance use disordersFeatures of substance use disordersResponse to treatmentNeurobiological basisAddiction neuroscienceIndividual treatment outcomesPsychiatric conditionsDetecting response to treatmentPsychological phenomenaNeuromarkersIndex riskSeverity of pathologyTreatment outcomesAbnormal processingAddictionPutative markerClinical practiceStable indicatorSevere pathologyAssess riskNeurosciencePathologyReview recent advancesDisordersTreatmentParameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity
Network A, Sangchooli A, Zare-Bidoky M, Jouzdani A, Schacht J, Bjork J, Claus E, Prisciandaro J, Wilson S, Wüstenberg T, Potvin S, Ahmadi P, Bach P, Baldacchino A, Beck A, Brady K, Brewer J, Childress A, Courtney K, Ebrahimi M, Filbey F, Garavan H, Ghahremani D, Goldstein R, Goudriaan A, Grodin E, Hanlon C, Haugg A, Heilig M, Heinz A, Holczer A, Van Holst R, Joseph J, Juliano A, Kaufman M, Kiefer F, Zonoozi A, Kuplicki R, Leyton M, London E, Mackey S, McClernon F, Mellick W, Morley K, Noori H, Oghabian M, Oliver J, Owens M, Paulus M, Perini I, Rafei P, Ray L, Sinha R, Smolka M, Soleimani G, Spanagel R, Steele V, Tapert S, Vollstädt-Klein S, Wetherill R, Witkiewitz K, Yuan K, Zhang X, Verdejo-Garcia A, Potenza M, Janes A, Kober H, Zilverstand A, Ekhtiari H. Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity. JAMA Psychiatry 2024, 81: 414-425. PMID: 38324323, DOI: 10.1001/jamapsychiatry.2023.5483.Peer-Reviewed Original ResearchTreatment developmentNeurobiology of drug addictionDrug cue reactivitySubstance use disordersBiomarkers of addictionCue reactivityAddictive disordersBiomarker developmentDrug addictionTreatment responseTreatment outcomesVisual cuesTask designCore aspectsAddictionClinical judgmentParticipant characteristicsDisordersOutcome predictorsClinical useMEDLINE databaseBiomarker qualificationSeveral biomarkersTranslational gapDatabase inceptionDevelopment and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder
Roos C, Kiluk B, Carroll K, Bricker J, Mun C, Sala M, Kirouac M, Stein E, John M, Palmer R, DeBenedictis A, Frisbie J, Haeny A, Barry D, Fucito L, Bowen S, Witkiewitz K, Kober H. Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder. Annals Of Medicine 2024, 56: 2315228. PMID: 38382111, PMCID: PMC10883107, DOI: 10.1080/07853890.2024.2315228.Peer-Reviewed Original ResearchConceptsSubstance use disordersMindfulness-based interventionsPhone coachingQualitative feedbackPromote recoveryEvidence of feasibilityUse disorderPhase 2Promote long-term recoveryApp featuresUnmet needsAdjunctive interventionTen adultsSmartphone appLong-term recoveryInterventionTherapy videosMindfulness practiceParticipantsOutpatient treatmentMind toolPhase 1CoachingAcceptance dimensionQuantitative ratings
2023
Emotion regulation and disordered eating behaviour in youths: Two daily‐diary studies
Dworschak C, Polack R, Winschel J, Joormann J, Kober H. Emotion regulation and disordered eating behaviour in youths: Two daily‐diary studies. European Eating Disorders Review 2023, 31: 655-669. PMID: 37293697, DOI: 10.1002/erv.2993.Peer-Reviewed Original ResearchConceptsEmotion regulationNegative affectPositive emotion regulationMaladaptive emotion regulationDisorder riskDaily diary designDaily diary studyUse of ruminationNegative emotionsDiary designRestrictive eatingWeight concernsRuminationPrevious researchCognitionWave 1YouthAffectEatingEmotionsCOVID-19 pandemicAdolescenceHigh levelsPresent studyBehaviorA Pilot Open Trial of a Digital Mindfulness-Based Intervention for Anorexia Nervosa
Sala M, Levinson C, Kober H, Roos C. A Pilot Open Trial of a Digital Mindfulness-Based Intervention for Anorexia Nervosa. Behavior Therapy 2023, 54: 637-651. PMID: 37330254, DOI: 10.1016/j.beth.2023.01.003.Peer-Reviewed Original ResearchConceptsEmotion regulationBody dissatisfactionState mindfulnessTrait mindfulnessSkill useDisorder symptomsAnorexia nervosaDigital mindfulness-based interventionMindfulness-based interventionsHigher state mindfulnessPilot open trialEcological momentary assessmentOpen trialPerson levelDaily lifeMeasures of acceptabilityED symptomsMindfulnessMomentary assessmentDigital mindfulnessDaily meditationMotivational supportAcceptability ratingsPost changesDissatisfaction
2022
A neuromarker for drug and food craving distinguishes drug users from non-users
Koban L, Wager T, Kober H. A neuromarker for drug and food craving distinguishes drug users from non-users. Nature Neuroscience 2022, 26: 316-325. PMID: 36536243, DOI: 10.1038/s41593-022-01228-w.Peer-Reviewed Original ResearchConceptsFood cravingsFunctional magnetic resonance imaging studySelf-regulation strategiesCue-induced drugMagnetic resonance imaging studySelf-reported intensityResonance imaging studyFood cuesVentromedial prefrontalSubstance use disordersIntrospective accessMaladaptive behaviorsNeurobiological markersNeurobiological mechanismsParietal association areasCingulate cortexVentral striatumConvergent validityCore featuresCravingAssociation areasSubstance useNeuromarkersUse disordersClinical interventionsAssociation of Drug Cues and Craving With Drug Use and Relapse
Vafaie N, Kober H. Association of Drug Cues and Craving With Drug Use and Relapse. JAMA Psychiatry 2022, 79: 641-650. PMID: 35648415, PMCID: PMC9161117, DOI: 10.1001/jamapsychiatry.2022.1240.Peer-Reviewed Original ResearchBrief training in regulation of craving reduces cigarette smoking
Lopez RB, Ochsner KN, Kober H. Brief training in regulation of craving reduces cigarette smoking. Journal Of Substance Use And Addiction Treatment 2022, 138: 108749. PMID: 35216868, DOI: 10.1016/j.jsat.2022.108749.Peer-Reviewed Original ResearchConceptsRegulation of cravingCognitive behavioral therapySmoking behaviorCognitive regulationLikelihood of relapseCognitive strategiesCue exposureRegulation strategiesTraining conditionsBrief trainingSubsequent smoking behaviorParticipants' smokingTraining procedureSmoking cessationCravingDSM-5Training groupNegative consequencesDaily diariesTraining sessionsCigarette smokingParticipantsDaily lifeAverage cigarettesDiagnostic criteriaA methodological checklist for fMRI drug cue reactivity studies: development and expert consensus
Ekhtiari H, Zare-Bidoky M, Sangchooli A, Janes AC, Kaufman MJ, Oliver JA, Prisciandaro JJ, Wüstenberg T, Anton RF, Bach P, Baldacchino A, Beck A, Bjork JM, Brewer J, Childress AR, Claus ED, Courtney KE, Ebrahimi M, Filbey FM, Ghahremani DG, Azbari PG, Goldstein RZ, Goudriaan AE, Grodin EN, Hamilton JP, Hanlon CA, Hassani-Abharian P, Heinz A, Joseph JE, Kiefer F, Zonoozi AK, Kober H, Kuplicki R, Li Q, London ED, McClernon J, Noori HR, Owens MM, Paulus MP, Perini I, Potenza M, Potvin S, Ray L, Schacht JP, Seo D, Sinha R, Smolka MN, Spanagel R, Steele VR, Stein EA, Steins-Loeber S, Tapert SF, Verdejo-Garcia A, Vollstädt-Klein S, Wetherill RR, Wilson SJ, Witkiewitz K, Yuan K, Zhang X, Zilverstand A. A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus. Nature Protocols 2022, 17: 567-595. PMID: 35121856, PMCID: PMC9063851, DOI: 10.1038/s41596-021-00649-4.Peer-Reviewed Original ResearchConceptsSubstance use disordersSystematic reviewReporting of itemsMagnetic resonance imaging studyDelphi consensus methodResonance imaging studyFunctional magnetic resonance imaging studyInitial checklistCue-reactivity studiesConsensus statementSUD treatmentConsensus paperUse disordersExpert consensusImaging studiesTask-based fMRICue reactivityIncomplete reportingMethodological checklistStructured recommendationsFMRI informationClinical translationChecklistFinal checklistReviewMeta-analysis of human prediction error for incentives, perception, cognition, and action
Corlett PR, Mollick JA, Kober H. Meta-analysis of human prediction error for incentives, perception, cognition, and action. Neuropsychopharmacology 2022, 47: 1339-1349. PMID: 35017672, PMCID: PMC9117315, DOI: 10.1038/s41386-021-01264-3.Peer-Reviewed Original ResearchConceptsPE signalsDorsomedial prefrontal cortexFamily-wise error correctionPrediction errorHealthy adult participantsSocial inferenceVisual hierarchyVisual perceptionActivation coordinatesFunctional neuroimagingPrefrontal cortexCognitive functionComputational neuroscienceAdult participantsCognitionNeural firingPerceptionError signalArtificial intelligenceTheoretical modelSmall sample sizeWhole brainNeuroscienceRewardMKDA
2021
The Role of Self-Regulation Strategies in Recovery from Alcohol Use Disorder
Roos C, Bowen S, Kober H. The Role of Self-Regulation Strategies in Recovery from Alcohol Use Disorder. 2021, 41-59. DOI: 10.1017/9781108976213.007.ChaptersThe self in context: brain systems linking mental and physical health
Koban L, Gianaros PJ, Kober H, Wager TD. The self in context: brain systems linking mental and physical health. Nature Reviews Neuroscience 2021, 22: 309-322. PMID: 33790441, PMCID: PMC8447265, DOI: 10.1038/s41583-021-00446-8.Peer-Reviewed Original ResearchConceptsVentromedial prefrontal cortexDefault mode networkPhysical healthPrefrontal cortexHigh-level cognitionCause of experienceBrain systemsSomatic physiologySensory modalitiesNeural systemsPersonal meaningPeripheral physiologyMental healthFormation of narrativesConvergent alterationsSelfContext modelCortexImmune functionCognitionExperienceContextHealthBeliefsMindset
2020
Computational Models of Drug Use and Addiction: A Review
Mollick JA, Kober H. Computational Models of Drug Use and Addiction: A Review. Journal Of Psychopathology And Clinical Science 2020, 129: 544-555. PMID: 32757599, PMCID: PMC7416739, DOI: 10.1037/abn0000503.Peer-Reviewed Original ResearchConceptsBrain-based modelsBehavioral controlComputational modelGoal-directed systemAspects of addictionCurrent computational modelsExecutive control circuitPredictive coding approachSymptoms of addictionModel of learningComputational accountPrediction errorComputational theoryPrefrontal cortexDrug useBrain areasDorsal striatumAddictionDopamine systemEffects of drugsBasal gangliaHuman dataCoding approachesBroad categoriesMotivationRegulating food craving: From mechanisms to interventions
Sun W, Kober H. Regulating food craving: From mechanisms to interventions. Physiology & Behavior 2020, 222: 112878. PMID: 32298667, PMCID: PMC7321886, DOI: 10.1016/j.physbeh.2020.112878.Peer-Reviewed Original ResearchConceptsCognitive strategiesCue reactivityNeural mechanismsCue-induced cravingUnderlying neural mechanismsToxic food environmentSubsequent food choiceFood cravingsCommon experienceCravingFood choicesStrong desireWeight outcomesFuture directionsCausal effectClinical perspectiveImportant lineInterventionTaskFood environmentCaloric consumptionPromising effectsObesity epidemicIndividualsExperience
2019
Regulation of Craving and Negative Emotion in Alcohol Use Disorder
Suzuki S, Mell MM, O'Malley SS, Krystal JH, Anticevic A, Kober H. Regulation of Craving and Negative Emotion in Alcohol Use Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 239-250. PMID: 31892465, PMCID: PMC7010564, DOI: 10.1016/j.bpsc.2019.10.005.Peer-Reviewed Original ResearchConceptsAlcohol use disorderNegative emotionsNegative affectPrefrontal cortexIndividual differencesRegulation conditionsCognitive behavioral therapy treatmentEmotion regulation taskFunctional magnetic resonance imagingNegative affect conditionRegulation of cravingNegative alcohol expectanciesNotable individual differencesSelf-reported cravingBehavioral therapy treatmentUse disordersRegulation successCognitive strategiesAffect conditionRegulation strategiesAlcohol expectanciesPFC regionsNeural mechanismsRegulation taskAUD treatmentLet it be: mindful acceptance down-regulates pain and negative emotion
Kober H, Buhle J, Weber J, Ochsner KN, Wager TD. Let it be: mindful acceptance down-regulates pain and negative emotion. Social Cognitive And Affective Neuroscience 2019, 14: 1147-1158. PMID: 31989171, PMCID: PMC7057281, DOI: 10.1093/scan/nsz104.Peer-Reviewed Original ResearchConceptsMindful acceptanceEmotion regulation strategiesCognitive control systemPrefrontal control systemsMeditation-naïve participantsSelf-report measuresKinds of stimuliEmotion regulationNeutral imagesNegative emotionsAmygdala responseMindfulness trainingNegative affectAffective significanceEmotional intensityRegulation strategiesBrain processesNegative imageInitial appraisalEmotionsLateral pain systemPain systemStimuliParticipantsChronic pain
2018
Training in cognitive strategies reduces eating and improves food choice
Boswell RG, Sun W, Suzuki S, Kober H. Training in cognitive strategies reduces eating and improves food choice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e11238-e11247. PMID: 30420496, PMCID: PMC6275472, DOI: 10.1073/pnas.1717092115.Peer-Reviewed Original ResearchConceptsCognitive strategiesFood valuationBrief trainingUnhealthy foodsCognitive regulation strategiesFood choicesEffects of framingRegulation strategiesStudy 5Study 1Study 3Unhealthy eatingStudy 6Training componentHealthy food choicesNegative consequencesPositive benefitsCravingHealthy foodsTrainingClinical implicationsPrior workIndividualsImplicationsEating