2023
Biological embedding of early trauma: the role of higher prefrontal synaptic strength
Tamman A, Jiang L, Averill C, Mason G, Averill L, Abdallah C. Biological embedding of early trauma: the role of higher prefrontal synaptic strength. European Journal Of Psychotraumatology 2023, 14: 2246338. PMID: 37642398, PMCID: PMC10467533, DOI: 10.1080/20008066.2023.2246338.Peer-Reviewed Original ResearchConceptsEarly traumaApproach/avoidance tendenciesReward responsivityAvoidance tendenciesBehavioral inhibitionSynaptic strengthPutative measurePhysical healthBiological embeddingHealthy controlsLarge human samplePTSDSynaptic processesGlutamatergic synaptic strengthPsychiatric disordersHigher EPCHuman samplesStudy findingsGlutamatergic excitotoxicityPharmacological treatmentDirect measureMeasuresTraumaEmotionsSynaptic plasticity
2020
Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine
Mishra PK, Adusumilli M, Deolal P, Mason GF, Kumar A, Patel AB. Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine. Neurochemistry International 2020, 137: 104750. PMID: 32360130, DOI: 10.1016/j.neuint.2020.104750.Peer-Reviewed Original ResearchConceptsChronic unpredictable mild stressCUMS micePrefrontal cortexChronic unpredictable mild stress (CUMS) modelNeurotransmitter cyclingThree-compartment metabolic modelUnpredictable mild stressCause of disabilityNMDA receptor antagonistPotential therapeutic roleMajor depressive disorderAstrocytic TCA cycleNeural metabolic activityMetabolic activityGABAergic neuronsInhibitory neurotransmissionReceptor antagonistSwim testSucrose preferenceC57BL6 miceDepressive disorderTherapeutic roleChronic depressionGlutamatergic pathwaysMetabolic deficits
2017
The human brain produces fructose from glucose
Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. The human brain produces fructose from glucose. JCI Insight 2017, 2: e90508. PMID: 28239653, PMCID: PMC5313070, DOI: 10.1172/jci.insight.90508.Peer-Reviewed Original ResearchConceptsPolyol pathwayFructose levelsIntracerebral glucoseBlood-brain barrierPathogenesis of obesityType 2 diabetesEffects of fructoseHuman brainRegression model analysisCNS deliveryCNS effectsHyperglycemic clampHealthy subjectsDietary consumptionGlucoseBaselineBrainMixed-effects regression model analysisFeeding behaviorMinutesCN productionObesityDiabetesLevelsPathogenesis
2016
Reproducibility measurement of glutathione, GABA, and glutamate: Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7T
Prinsen H, de Graaf RA, Mason GF, Pelletier D, Juchem C. Reproducibility measurement of glutathione, GABA, and glutamate: Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7T. Journal Of Magnetic Resonance Imaging 2016, 45: 187-198. PMID: 27351712, PMCID: PMC5167659, DOI: 10.1002/jmri.25356.Peer-Reviewed Original Research
2014
Glutamate Metabolism in Major Depressive Disorder
Abdallah CG, Jiang L, De Feyter HM, Fasula M, Krystal JH, Rothman DL, Mason GF, Sanacora G. Glutamate Metabolism in Major Depressive Disorder. American Journal Of Psychiatry 2014, 171: 1320-1327. PMID: 25073688, PMCID: PMC4472484, DOI: 10.1176/appi.ajp.2014.14010067.Peer-Reviewed Original Research
2013
Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure
Wang J, Du H, Jiang L, Ma X, de Graaf RA, Behar KL, Mason GF. Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 14444-14449. PMID: 23940368, PMCID: PMC3761635, DOI: 10.1073/pnas.1306011110.Peer-Reviewed Original ResearchConceptsChronic ethanol exposureEthanol-naïve ratsAlcohol exposureEthanol exposureAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsMin/Chronic alcohol exposureCerebral glucose metabolismAcute alcohol exposureEthanol-treated ratsSprague-Dawley ratsCortical astrogliaOverall oxidative metabolismRat brainGlucose metabolismRatsRoom airLiving brainAstrogliaSubcortical tissueOxidative metabolismNeuronsBrainOxidative damageLactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia
Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Journal Of Clinical Investigation 2013, 123: 1988-1998. PMID: 23543056, PMCID: PMC3638906, DOI: 10.1172/jci65105.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaRecurrent hypoglycemiaHypoglycemic conditionsIntensive insulin therapyTight glycemic controlType 2 diabetesInsulin therapyGlycemic controlBrain metabolismElevated lactateNeuronal metabolismRodent modelsNeuronal activityGlucose metabolismHypoglycemiaLactate uptakeNeuronal functionType 1Metabolic regulatorOxidative capacityModest incrementLactateMetabolismUnexpected findingBrain
2011
Intravenous Ethanol Infusion Decreases Human Cortical γ-Aminobutyric Acid and N-Acetylaspartate as Measured with Proton Magnetic Resonance Spectroscopy at 4 Tesla
Gomez R, Behar KL, Watzl J, Weinzimer SA, Gulanski B, Sanacora G, Koretski J, Guidone E, Jiang L, Petrakis IL, Pittman B, Krystal JH, Mason GF. Intravenous Ethanol Infusion Decreases Human Cortical γ-Aminobutyric Acid and N-Acetylaspartate as Measured with Proton Magnetic Resonance Spectroscopy at 4 Tesla. Biological Psychiatry 2011, 71: 239-246. PMID: 21855054, PMCID: PMC3227760, DOI: 10.1016/j.biopsych.2011.06.026.Peer-Reviewed Original ResearchConceptsIntravenous ethanol infusionProton magnetic resonance spectroscopyEthanol infusionNAA levelsN-acetylaspartateCortical γ-aminobutyric acidAcute pharmacologic effectsLevels of GABAHealthy social drinkersBreath alcohol levelsN-acetylaspartyl-glutamateCortical GABAEthanol modulatesFirst infusionΓ-aminobutyric acidGABA levelsPharmacologic effectsBrain ethanolOccipital GABAInfusionAlcohol levelsMagnetic resonance spectroscopyReceptor functionBreath ethanolHuman cortex
2010
Regional metabolite levels and turnover in the awake rat brain under the influence of nicotine
Wang J, Jiang L, Jiang Y, Ma X, Chowdhury GM, Mason GF. Regional metabolite levels and turnover in the awake rat brain under the influence of nicotine. Journal Of Neurochemistry 2010, 113: 1447-1458. PMID: 20345764, PMCID: PMC2903655, DOI: 10.1111/j.1471-4159.2010.06684.x.Peer-Reviewed Original ResearchConceptsRat brainN-acetylaspartateAcute nicotine treatmentBrain glucose oxidationAmino acid neurotransmittersInfluence of nicotineConcentration of glutamateRegional metabolite levelsAwake rat brainRelated neurochemicalsNicotine treatmentInhibitory neurotransmissionAcute effectsOlfactory bulbOccipital cortexNeurotransmitter cyclingGABA synthesisNicotineStriatumBrainMetabolite levelsWidespread drugGABACortexPotential interplay
2009
Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy
Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL, Petersen KF. Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy. Cerebrovascular And Brain Metabolism Reviews 2009, 30: 211-221. PMID: 19794401, PMCID: PMC2949111, DOI: 10.1038/jcbfm.2009.197.Peer-Reviewed Original ResearchConceptsNeuronal mitochondrial metabolismHealthy agingBrain mitochondrial metabolismElderly subjectsYoung subjectsBrain functionBrain mitochondrial functionGlutamate-glutamine cyclingMitochondrial metabolismVivo magnetic resonance spectroscopyAge-related changesChronic reductionLabeling of glutamineGlutamate concentrationYoung volunteersBiologic basisMagnetic resonance spectroscopyMitochondrial functionMetabolismSubjectsIndividual subjectsResonance spectroscopyTricarboxylic acid cycleCycle fluxAging
2006
Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1‐13C] and [2‐13C] glucose
Mason GF, Petersen KF, De Graaf RA, Shulman GI, Rothman DL. Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1‐13C] and [2‐13C] glucose. Journal Of Neurochemistry 2006, 100: 73-86. PMID: 17076763, PMCID: PMC2995551, DOI: 10.1111/j.1471-4159.2006.04200.x.Peer-Reviewed Original ResearchConceptsHuman cerebral cortexCerebral cortexArterial-venous differencesAwake humansNeurotransmitter cyclingGlutamine effluxNeurotransmitter traffickingOccipital-parietal regionsGlutamateCortexPyruvate carboxylase fluxRecent studiesGlutamine synthesisPyruvate carboxylaseMagnetic resonance spectroscopyMost studiesGlutaminePyruvate dehydrogenaseIncreased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes
Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes. Diabetes 2006, 55: 929-934. PMID: 16567513, PMCID: PMC2995526, DOI: 10.2337/diabetes.55.04.06.db05-1325.Peer-Reviewed Original ResearchConceptsType 1 diabetesDiabetic subjectsControl subjectsType 1 diabetic subjectsInsulin-induced hypoglycemiaNondiabetic control subjectsMonocarboxylic acid transportBrain utilizationSimilar twofold increaseBrain energeticsHypoglycemiaType 1DiabetesOxidative metabolismNonglucose substratesBrainMetabolic substratesUpregulationPatientsAcid transportTwofold increaseSubjectsMagnetic resonance spectroscopyLactateMetabolism
2001
Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD67 protein
Mason G, Martin D, Martin S, Manor D, Sibson N, Patel A, Rothman D, Behar K. Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD67 protein. Brain Research 2001, 914: 81-91. PMID: 11578600, DOI: 10.1016/s0006-8993(01)02778-0.Peer-Reviewed Original ResearchConceptsTotal GAD activityGAD activityNon-treated control groupGABA-transaminase inhibitionNitrous oxide anesthesiaCortex of controlGlutamate-glutamine cyclingGlutamic acid decarboxylaseGABA synthesis rateGamma-aminobutyric acid (GABA) synthesisVigabatrin treatmentOxide anesthesiaRat cortexGAD67 proteinControl groupBasal conditionsAcid decarboxylaseEx vivoNeuronal compartmentsVigabatrinQuantitative immunoblottingIsoform compositionRatsCortexInhibitionIn vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion
Sibson N, Mason G, Shen J, Cline G, Herskovits A, Wall J, Behar K, Rothman D, Shulman R. In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion. Journal Of Neurochemistry 2001, 76: 975-989. PMID: 11181817, DOI: 10.1046/j.1471-4159.2001.00074.x.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cyclingCerebral cortexAstrocytic tricarboxylic acid cycleGlutamine cyclingRat cerebral cortexGlutamine synthesisDe novo glutamine synthesisAnesthetized ratsRat brainNeurotransmitter glutamateHyperammonemic conditionsGlutamate cyclingInfusionGlutamate precursorCortexBrainTCA cycle fluxAnaplerosisMajor metabolic fluxTricarboxylic acid cycleCycle fluxDifferential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro
Novotny E, Ariyan C, Mason G, O’Reilly J, Haddad G, Behar K. Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro. Brain Research 2001, 888: 193-202. PMID: 11150475, DOI: 10.1016/s0006-8993(00)03051-1.Peer-Reviewed Original ResearchConceptsGlucose oxidative metabolismNeocortical slicesOxidative metabolismRat postnatal developmentCortical glutamateCerebral cortexCortex maturesPostnatal dayPostnatal developmentAge groupsCortexMitochondrial TCA cycleGreater increaseVivoGlucose oxidationTCA cycle fluxDifferential increaseAcid extractsMetabolismSlicesDeafferentiationCycle fluxRats
1999
Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR
Shen J, Petersen K, Behar K, Brown P, Nixon T, Mason G, Petroff O, Shulman G, Shulman R, Rothman D. Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 8235-8240. PMID: 10393978, PMCID: PMC22218, DOI: 10.1073/pnas.96.14.8235.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cycleGlutamine cycleCerebral cortexMin/Rat cerebral cortexVivo 13C NMR spectraGlucose oxidation ratesHuman brainGlucose oxidationGlutamatergic activityRat modelTricarboxylic acid cycle rateParietal lobeHuman cortexCortexTime courseBrainGlutamine synthesisMajor metabolic fluxCycle rateTricarboxylic acid cycleHigh levelsInfusionRatsAcid cycle
1998
Lateralization of human temporal lobe epilepsy by 31P NMR spectroscopic imaging at 4.1 T
Chu W, Hetherington H, Kuzniecky R, Simor T, Mason G, Elgavish G. Lateralization of human temporal lobe epilepsy by 31P NMR spectroscopic imaging at 4.1 T. Neurology 1998, 51: 472-479. PMID: 9710021, DOI: 10.1212/wnl.51.2.472.Peer-Reviewed Original ResearchConceptsMesial temporal lobeTemporal lobe epilepsy patientsTemporal lobe epilepsyPCr/PiTemporal lobeClinical lateralizationLobe epilepsySeizure focusEpilepsy patientsHealthy volunteersHuman temporal lobe epilepsyPi ratioSubgroup of patientsIpsilateral lobePresurgical lateralizationContralateral lobeLateralization resultsPatientsMetabolite ratiosNoninvasive modalityNoninvasive methodLateralizationScalp EEGAnterior regionIntracranial EEGEvaluation of 31P metabolite differences in human cerebral gray and white matter
Mason G, Chu W, Vaughan J, Ponder S, Twieg D, Adams D, Hetherington H. Evaluation of 31P metabolite differences in human cerebral gray and white matter. Magnetic Resonance In Medicine 1998, 39: 346-353. PMID: 9498589, DOI: 10.1002/mrm.1910390303.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAdultAlgorithmsBrainBrain DiseasesEnergy MetabolismEvaluation Studies as TopicFemaleFourier AnalysisHumansHydrogen-Ion ConcentrationImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMalePhosphatesPhosphocreatinePhosphorusPhosphorus IsotopesRegression AnalysisStoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
Sibson N, Dhankhar A, Mason G, Rothman D, Behar K, Shulman R. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 316-321. PMID: 9419373, PMCID: PMC18211, DOI: 10.1073/pnas.95.1.316.Peer-Reviewed Original ResearchConceptsGlutamatergic neuronal activityGlutamate neurotransmitter cyclingNeuronal activityGln synthesisBrain glucose metabolismSynaptic glutamate releaseGlc metabolismGlutamate releaseRat cortexSynaptic activityGlucose metabolismNeuronal functionBrain activation studiesTricarboxylic acid cycleCortexMetabolismAcid cycleActivation studiesAstrocytesNeuronsActivity
1997
Oxidative Glucose Metabolism in Rat Brain During Single Forepaw Stimulation: A Spatially Localized 1H[13C] Nuclear Magnetic Resonance Study
Hyder F, Rothman* D, Mason† G, Rangarajan A, Behar‡ K, Shulman R. Oxidative Glucose Metabolism in Rat Brain During Single Forepaw Stimulation: A Spatially Localized 1H[13C] Nuclear Magnetic Resonance Study. Cerebrovascular And Brain Metabolism Reviews 1997, 17: 1040-1047. PMID: 9346428, DOI: 10.1097/00004647-199710000-00005.Peer-Reviewed Original Research