2022
A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth
Horien C, Greene A, Shen X, Fortes D, Brennan-Wydra E, Banarjee C, Foster R, Donthireddy V, Butler M, Powell K, Vernetti A, Mandino F, O'Connor D, Lake E, McPartland J, Volkmar F, Chun M, Chawarska K, Rosenberg M, Scheinost D, Constable R. A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth. Cerebral Cortex 2022, 33: 6320-6334. PMID: 36573438, PMCID: PMC10183743, DOI: 10.1093/cercor/bhac506.Peer-Reviewed Original ResearchConceptsAttention taskAttentional stateConnectome-based predictive modelingNeurodiverse conditionsSustained attention taskAttention network modelSample of youthNeurotypical participantsSustained attentionBrain correlatesNeurobiological correlatesAttention networkIndividual participantsSeparate samplesYouthParticipantsHead motionTaskCorrelatesAttentionAutismConfoundsNetwork modelGeneralizesHealthcare settings
2009
A genome-wide linkage and association scan reveals novel loci for autism
Daly M, Chakravarti A, Arking D, Brune C, West K, O’Connor A, Hilton G, Tomlinson R, West A, Cook Jr E, Chakravarti A, Weiss L, Green T, Chang S, Gabriel S, Gates C, Hanson E, Kirby A, Korn J, Kuruvilla F, McCarroll S, Morrow E, Neale B, Purcell S, Sasanfar R, Sougnez C, Stevens C, Altshuler D, Gusella J, Santangelo S, Sklar P, Tanzi R, Daly M, Anney R, Bailey A, Baird G, Battaglia A, Berney T, Betancur C, Bölte S, Bolton P, Brian J, Bryson S, Buxbaum J, Cabrito I, Cai G, Cantor R, Cook Jr E, Coon H, Conroy J, Correia C, Corsello C, Crawford E, Cuccaro M, Dawson G, de Jonge M, Devlin B, Duketis E, Ennis S, Estes A, Farrar P, Fombonne E, Freitag C, Gallagher L, Geschwind D, Gilbert J, Gill M, Gillberg C, Goldberg J, Green A, Green J, Guter S, Haines J, Hallmayer J, Hus V, Klauck S, Korvatska O, Lamb J, Laskawiec M, Leboyer M, Le Couteur A, Leventhal B, Liu X, Lord C, Lotspeich L, Maestrini E, Magalhaes T, Mahoney W, Mantoulan C, McConachie H, McDougle C, McMahon W, Marshall C, Miller J, Minshew N, Monaco A, Munson J, Nurnberger Jr J, Oliveira G, Pagnamenta A, Papanikolaou K, Parr J, Paterson A, Pericak-Vance M, Pickles A, Pinto D, Piven J, Posey D, Poustka A, Poustka F, Regan R, Reichert J, Renshaw K, Roberts W, Roge B, Rutter M, Salt J, Schellenberg G, Scherer S, Sheffield V, Sutcliffe J, Szatmari P, Tansey K, Thompson A, Tsiantis J, Van Engeland H, Vicente A, Vieland V, Volkmar F, Wallace S, Wassink T, Wijsman E, Wing K, Wittemeyer K, Yaspan B, Zwaigenbaum L, Morrow E, Yoo S, Sean Hill R, Mukaddes N, Balkhy S, Gascon G, Al-Saad S, Hashmi A, Ware J, Joseph R, LeClair E, Partlow J, Barry B, Walsh C, Pauls D, Moilanen I, Ebeling H, Mattila M, Kuusikko S, Jussila K, Ignatius J, Sasanfar R, Tolouei A, Ghadami M, Rostami M, Hosseinipour A, Valujerdi M, Santangelo S, Andresen K, Winkloski B, Haddad S, Kunkel L, Kohane Z, Tran T, Won Kong S, O’Neil S, Hanson E, Hundley R, Holm I, Peters H, Baroni E, Cangialose A, Jackson L, Albers L, Becker R, Bridgemohan C, Friedman S, Munir K, Nazir R, Palfrey J, Schonwald A, Simmons E, Rappaport L, Gauthier J, Mottron L, Joober R, Fombonne E, Rouleau G, Rehnstrom K, von Wendt L, Peltonen L. A genome-wide linkage and association scan reveals novel loci for autism. Nature 2009, 461: 802-808. PMID: 19812673, PMCID: PMC2772655, DOI: 10.1038/nature08490.Peer-Reviewed Original ResearchConceptsGenome-wide SNPsSusceptibility genesGenome-wide linkageGenome-wide scanSpecific susceptibility genesAutism susceptibility genesExpression of SEMA5AHeritable neurodevelopmental disorderAssociation scanNovel lociChromosome 5p15Multiplex autism familiesLinkage regionAutism familiesSignificant linkageNovel associationsGenesSEMA5ARare variationNeurodevelopmental disordersCommon setLociSNPsExpressionTAS2R1
2001
Language regression in childhood.
Shinnar S, Rapin I, Arnold S, Tuchman R, Shulman L, Ballaban-Gil K, Maw M, Deuel R, Volkmar F. Language regression in childhood. Pediatric Neurology 2001, 24: 183-9. PMID: 11301218, DOI: 10.1016/s0887-8994(00)00266-6.Peer-Reviewed Original ResearchMeSH KeywordsBrainChildChild Behavior DisordersChild LanguageChild, PreschoolCognition DisordersElectroencephalographyFemaleHumansInfantLandau-Kleffner SyndromeLanguage DisordersLanguage TestsMagnetic Resonance ImagingMaleProspective StudiesRegression, PsychologySeverity of Illness IndexTomography, Emission-Computed, Single-PhotonVerbal BehaviorConceptsYears of ageLanguage regressionAutistic regressionMajor medical centersMonths of ageClinical characteristicsEpileptic aphasiaSpecialist referralMean ageElectroencephalogram abnormalitiesMedical CenterEarly identificationMost childrenSeizuresMean timeAutistic featuresAgeAutistic behaviorChildrenLanguage functionReferralMonthsRegressionPatientsYears
2000
Research Units on Pediatric Psychopharmacology (Rupp) Autism Network Background and Rationale for an Initial Controlled Study of Risperidone
McDougle C, Scahill L, McCracken J, Aman M, Tierney E, Arnold L, Freeman B, Martin A, McGough J, Cronin P, Posey D, Riddle M, Ritz L, Swiezy N, Vitiello B, Volkmar F, Votolato N, Walson P. Research Units on Pediatric Psychopharmacology (Rupp) Autism Network Background and Rationale for an Initial Controlled Study of Risperidone. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 201-224. PMID: 10674197, DOI: 10.1016/s1056-4993(18)30142-1.Peer-Reviewed Original ResearchConceptsOpen-label trialDA neuronal systemsSafety of risperidoneStudy of RisperidonePlacebo-controlled studyUse of risperidoneExtrapyramidal side effectsTarget of pharmacotherapyTreatment of childrenImpaired social behaviorLong-term effectivenessPreclinical evidenceReceptor blockadeTypical antipsychoticsControlled StudyFirst drugPathophysiology of autismLower riskShort-term benefitsSide effectsRisperidonePotent effectsSymptoms of autismNeuronal systemsEnhanced efficacy
1994
Noradrenergic and adrenergic functioning in autism
Minderaa R, Anderson G, Volkmar F, Akkerhuis G, Cohen D. Noradrenergic and adrenergic functioning in autism. Biological Psychiatry 1994, 36: 237-241. PMID: 7986888, DOI: 10.1016/0006-3223(94)90605-x.Peer-Reviewed Original ResearchConceptsUrinary excretion rateNeurochemical assessmentVanillylmandelic acidAdrenergic functioningExcretion rateNormal control individualsUrinary excretionPlasma levelsNoradrenergic functioningMarked abnormalitiesNormal controlsGroup mean differencesControl groupControl individualsNorepinephrineMean differenceAutistic patients
1993
Acute tryptophan depletion in autistic disorder: A controlled case study
McDougle C, Naylor S, Goodman W, Volkmar F, Cohen D, Price L. Acute tryptophan depletion in autistic disorder: A controlled case study. Biological Psychiatry 1993, 33: 547-550. PMID: 8513041, DOI: 10.1016/0006-3223(93)90011-2.Peer-Reviewed Original ResearchIntegrating biological and behavioral perspectives in the study and care of autistic individuals: the future.
Cohen D, Volkmar F, Anderson G, Klin A. Integrating biological and behavioral perspectives in the study and care of autistic individuals: the future. Israel Journal Of Psychiatry And Related Sciences 1993, 30: 15-32. PMID: 8101835.Peer-Reviewed Original Research
1987
Clinical Features of Autistic Children with Setback Course in Their Infancy
Hoshino Y, Kaneko M, Yashima Y, Kumashiro H, Volkmar F, Cohen D. Clinical Features of Autistic Children with Setback Course in Their Infancy. Psychiatry And Clinical Neurosciences 1987, 41: 237-245. PMID: 3437611, DOI: 10.1111/j.1440-1819.1987.tb00407.x.Peer-Reviewed Original ResearchConceptsType of onsetAcquired groupClinical featuresHigh incidenceYears of ageInfantile autismSevere behavioral disordersPerinatal abnormalitiesFebrile convulsionsBrain dysfunctionIncidence rateHyperkinetic behaviorSelf-abusive behaviorEpileptic seizuresAutistic childrenBehavioral disordersIncidenceStereotypic behaviorOnsetDevelopmental levelAgeSubgroupsGroupChildrenPrognosis