Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition
Shi X, Sousa LP, Mandel-Bausch EM, Tome F, Reshetnyak AV, Hadari Y, Schlessinger J, Lax I. Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e4784-e4793. PMID: 27482095, PMCID: PMC4995958, DOI: 10.1073/pnas.1610179113.Peer-Reviewed Original ResearchConceptsTyrosine kinase inhibitorsCombination of TKIsAnti-Kit antibodiesKIT mutantsPrecision medicine treatmentAntibody treatmentMedicine treatmentLow dosePrecision medicine effortsToxin conjugatesKIT inhibitorsActivating mutationsDistinct cellular propertiesReceptor tyrosine kinasesKinase inhibitorsCell inhibitionCancer cellsGenomic sequencing analysisCancer cell inhibitionMedicine effortsCancerTreatmentTyrosine kinaseSequencing analysisInhibitors