2023
Recent advances in epilepsy surgery
Medina-Pizarro M, Spencer D, Damisah E. Recent advances in epilepsy surgery. Current Opinion In Neurology 2023, 36: 95-101. PMID: 36762633, DOI: 10.1097/wco.0000000000001134.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyElectroencephalographyEpilepsyHumansPrognosisSeizuresTreatment OutcomeConceptsEpilepsy surgeryEpilepsy centersComprehensive Epilepsy CenterDrug-resistant epilepsySurgical outcome dataReasonable surgical alternativeAdequate trialAntiseizure medicationsPreoperative evaluationSurgical candidacySurgical outcomesSeizure networkSurgical alternativeEpileptogenic networksSurgical techniqueTreatment strategiesEpileptogenic regionInvasive techniquesOutcome dataSurgeryDepth electrodesHigh-resolution structural imagingSubtle abnormalitiesDiagnostic toolStructural imaging
2022
Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy
Sivaraju A, Hirsch L, Gaspard N, Farooque P, Gerrard J, Xu Y, Deng Y, Damisah E, Blumenfeld H, Spencer DD. Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy. Neurology 2022, 99: e1-e10. PMID: 35508395, PMCID: PMC9259091, DOI: 10.1212/wnl.0000000000200569.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyElectrocorticographyElectroencephalographyHumansMagnetic Resonance ImagingRetrospective StudiesTreatment OutcomeConceptsTemporal lobe onsetSeizure freedomResective surgeryIndependent predictorsLesional MRIUnfavorable predictorRefractory epilepsyContinued medical treatmentEpilepsy surgical evaluationFactors Predicting OutcomeIntracranial EEG evaluationNonlesional extratemporal epilepsySubsequent seizure freedomSustained seizure freedomThorough presurgical evaluationSeizure-free outcomeClass II evidenceMedically Refractory EpilepsyRetrospective chart reviewKaplan-Meier curvesSelect clinical scenariosMultivariable regression analysisBest multivariable modelIntracranial EEGSeizure onset localization
2021
Management of patients with medically intractable epilepsy and anterior temporal lobe encephaloceles.
Sandhu MRS, Mandel M, McGrath H, Lamsam L, Farooque P, Bronen RA, Spencer DD, Damisah EC. Management of patients with medically intractable epilepsy and anterior temporal lobe encephaloceles. Journal Of Neurosurgery 2021, 136: 709-716. PMID: 34507290, DOI: 10.3171/2021.3.jns21133.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyElectroencephalographyEncephaloceleEpilepsy, Temporal LobeHumansMagnetic Resonance ImagingSeizuresTemporal LobeTreatment OutcomeConceptsTemporal lobe encephaloceleIdiopathic intracranial hypertensionRefractory epilepsyEEG findingsSigns of IIHIntractable temporal lobe epilepsyResective epilepsy surgeryManagement of patientsTemporal lobe epilepsyScalp EEG findingsSignificant neuropsychological deficitsRadiological findingsIntracranial hypertensionPreoperative evaluationEpileptogenic lesionsSurgical managementEpilepsy surgeryLobe epilepsySurgical outcomesIntractable epilepsySingle institutionSurgical dataEpileptogenic focusMedical recordsWorse outcomesIncreased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain
Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain. Epilepsia 2021, 62: e88-e97. PMID: 33949690, PMCID: PMC11259155, DOI: 10.1111/epi.16920.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acids, Branched-ChainBrain ChemistryChildChild, PreschoolChromatography, High Pressure LiquidDrug Resistant EpilepsyElectrocorticographyElectroencephalographyEpilepsies, PartialExtracellular SpaceFemaleGlutamic AcidHumansIsoleucineMaleMicrodialysisMiddle AgedSeizuresTandem Mass SpectrometryYoung AdultConceptsSpontaneous seizuresDrug-resistant focal epilepsyExtracellular brain glutamateHuman epileptic brainBranched-chain amino acidsBranched chain amino acids valineRefractory epilepsyBrain microdialysisGlutamatergic neurotransmissionFocal epilepsySeizure onsetBrain glutamateEpileptic brainHuman patientsSeizuresBrain regionsDialysis samplesMammalian targetEpilepsyLiquid chromatography-tandem mass spectrometryBaselineBCAAIntracranial electroencephalographyChromatography-tandem mass spectrometryPatientsDepth Electrode Guided Anterior Insulectomy: 2-Dimensional Operative Video
Mandel M, Lamsam L, Farooque P, Spencer D, Damisah E. Depth Electrode Guided Anterior Insulectomy: 2-Dimensional Operative Video. Operative Neurosurgery 2021, 21: e121-e121. PMID: 33885821, PMCID: PMC8493659, DOI: 10.1093/ons/opab112.Peer-Reviewed Original ResearchMeSH KeywordsCerebral CortexDrug Resistant EpilepsyElectrodes, ImplantedElectroencephalographyEpilepsyFemaleHumansConceptsDepth electrodesOperative VideoEntire right hemisphereRight-handed womanIntracranial EEG studiesIctal vocalizationInsular surgeryNeurological deficitsPreoperative evaluationRefractory epilepsyEpileptiform activityEpileptogenic areaEpileptic zoneInsular resectionFrontal operculumNoninvasive resultsPatientsAnterior borderOptimal outcomesRight hemisphereInsulectomyEEG studiesSurgeryIndescribable feelingNeuronavigation