2023
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses
Park E, Jeon H, Lee N, Yu J, Park H, Satoh T, Akira S, Furuyama T, Lee C, Choi J, Rho J. TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses. The EMBO Journal 2023, 42: e111867. PMID: 37203866, PMCID: PMC10308371, DOI: 10.15252/embj.2022111867.Peer-Reviewed Original ResearchMeSH Keywords14-3-3 ProteinsAnimalsEscherichia coliInflammation MediatorsLipopolysaccharidesMiceTranscription FactorsConceptsBone marrow-derived macrophagesInflammatory mediator productionInflammatory responseMediator productionTranscription factor FOXO1Lethal shockLPS-induced inflammatory responseSerum proinflammatory cytokine levelsToll-like receptor (TLR)-mediated inflammatory responsesFoxO1 activitySystemic inflammatory responseProinflammatory cytokine levelsMarrow-derived macrophagesTLR2/4 signaling pathwayFoxO1 nuclear accumulationT cellsCytokine levelsLipopolysaccharide (LPS)-induced inflammatory responsesTDAG51 deficiencyDouble deficiencyLPS-induced inflammatory mediator productionLPS stimulationInnate immunityCytoplasmic translocationLPS
2020
T-Cell Death-Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis
Kim S, Lee N, Park E, Yun H, Ha T, Jeon H, Yu J, Choi S, Shin B, Yu J, Dal Rhee S, Choi Y, Rho J. T-Cell Death-Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis. Molecules And Cells 2020, 44: 1-12. PMID: 33335079, PMCID: PMC7854182, DOI: 10.14348/molcells.2020.0143.Peer-Reviewed Original ResearchConceptsLigand-independent mannerRepeat domainRetinoid X receptorBinding domainNegative regulatorHeterodimer formationEarly stage of adipogenic differentiationActivation function-2 domainPleckstrin homology-likeT-cell death-associated geneDNA-binding domainDeletion mutant analysisDeath-associated genesStage of adipogenic differentiationLigand-binding domainMutant analysisGlutamine repeatsCell fateTranscriptional activityPeroxisome proliferator-activated receptor gTDAG51 expressionAdipocyte differentiationHeterodimer complexTDAG51Adipogenic cell fate
2019
TDAG51 is a crucial regulator of maternal care and depressive-like behavior after parturition
Yun H, Park E, Choi S, Shin B, Yu J, Yu J, Amarasekara D, Kim S, Lee N, Choi J, Choi Y, Rho J. TDAG51 is a crucial regulator of maternal care and depressive-like behavior after parturition. PLOS Genetics 2019, 15: e1008214. PMID: 31251738, PMCID: PMC6599150, DOI: 10.1371/journal.pgen.1008214.Peer-Reviewed Original ResearchConceptsDepressive-like behaviorPostpartum depressionDevelopment of postpartum depressionImpaired maternal behaviorRegulation of maternal careMonoamine neurotransmitter levelsCombination of physical changesNest-building testInfluence of genetic risk factorsTDAG51 deficiencyMaternity careGenetic risk factorsPup retrievalMental disordersPsychiatric illnessNeurotransmitter levelsMaternal behaviorPostpartumRisk factorsDepressionBuilding testsT-cell death-associated geneDeath-associated genesNursesCare
2014
Secretion of a Truncated Osteopetrosis-associated Transmembrane Protein 1 (OSTM1) Mutant Inhibits Osteoclastogenesis through Down-regulation of the B Lymphocyte-induced Maturation Protein 1 (BLIMP1)-Nuclear Factor of Activated T Cells c1 (NFATc1) Axis*
Shin B, Yu J, Park E, Choi S, Yu J, Hwang J, Yun H, Chung Y, Hong K, Choi J, Takami M, Rho J. Secretion of a Truncated Osteopetrosis-associated Transmembrane Protein 1 (OSTM1) Mutant Inhibits Osteoclastogenesis through Down-regulation of the B Lymphocyte-induced Maturation Protein 1 (BLIMP1)-Nuclear Factor of Activated T Cells c1 (NFATc1) Axis*. Journal Of Biological Chemistry 2014, 289: 35868-35881. PMID: 25359771, PMCID: PMC4276856, DOI: 10.1074/jbc.m114.589614.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone ResorptionCell DifferentiationCell FusionCell SurvivalCells, CulturedDown-RegulationGene ExpressionLipopolysaccharidesMaleMembrane ProteinsMice, Inbred C57BLNFATC Transcription FactorsOsteoclastsOsteoporosisPositive Regulatory Domain I-Binding Factor 1Signal TransductionTranscription FactorsConceptsSecreted formTransmembrane domainOsteopetrosis-associated transmembrane protein 1Down-regulationAutosomal recessive osteopetrosis patientsTransmembrane protein 1Marker genesCell surfaceActivated T cells c1Genetic defectsExpression of OC marker genesCell fusionFunctional roleGenetic mutationsAutosomal recessive osteopetrosisMutationsProtein 1Bone destruction in vivoGene mutationsGenesDestruction in vivoRecessive osteopetrosisOsteoclast (OCOsteopetrosis patientsOsteoclastogenic genes
2013
TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts
Park E, Kim J, Ha T, Choi J, Soo Hong K, Rho J. TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts. Experimental & Molecular Medicine 2013, 45: e35-e35. PMID: 23928855, PMCID: PMC3789259, DOI: 10.1038/emm.2013.67.Peer-Reviewed Original ResearchConceptsMouse embryonic fibroblastsApoptotic cell deathCell deathOxidative stress-induced apoptotic cell deathReactive oxygen speciesPleckstrin homology-like domain familyPromotes oxidative stress-induced apoptosisActivation of caspase-3Stress responseStress-induced cell deathT-cell death-associated genePro-apoptotic functionOxidative stress-induced cell deathOxidative stress-induced apoptosisTDAG51 deficiencyDeath-associated genesStress-induced apoptosisReceptor-mediated cell deathPro-apoptotic genesResponse to oxidative stressCellular stress responseEndoplasmic reticulum stressOxygen speciesProduction of intracellular reactive oxygen speciesIntracellular reactive oxygen species