2021
GABA-receptive microglia selectively sculpt developing inhibitory circuits
Favuzzi E, Huang S, Saldi G, Binan L, Ibrahim L, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi S, Bonneau R, Datta S, Stevens B, Fishell G. GABA-receptive microglia selectively sculpt developing inhibitory circuits. Cell 2021, 184: 4048-4063.e32. PMID: 34233165, PMCID: PMC9122259, DOI: 10.1016/j.cell.2021.06.018.Peer-Reviewed Original ResearchConceptsInhibitory cortical synapsesBrain wiringResident immune cellsMouse postnatal developmentBehavioral abnormalitiesImmune cellsInhibitory circuitsSynaptic refinementGlial cell typesExcitatory synapsesCortical synapsesPostnatal developmentMicrogliaSynapse typesInhibitory connectionsCell typesBrainRemodeling programSynapsesAbnormalitiesGABA
2020
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
Vormstein-Schneider D, Lin J, Pelkey K, Chittajallu R, Guo B, Arias-Garcia M, Allaway K, Sakopoulos S, Schneider G, Stevenson O, Vergara J, Sharma J, Zhang Q, Franken T, Smith J, Ibrahim L, Mastro K, Sabri E, Huang S, Favuzzi E, Burbridge T, Xu Q, Guo L, Vogel I, Sanchez V, Saldi G, Gorissen B, Yuan X, Zaghloul K, Devinsky O, Sabatini B, Batista-Brito R, Reynolds J, Feng G, Fu Z, McBain C, Fishell G, Dimidschstein J. Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans. Nature Neuroscience 2020, 23: 1629-1636. PMID: 32807948, PMCID: PMC8015416, DOI: 10.1038/s41593-020-0692-9.Peer-Reviewed Original ResearchConceptsRecombinant adeno-associated virus vectorAdeno-associated virus vectorVasoactive intestinal peptide-expressing interneuronsClasses of neuronsGene regulatory elementsGene SCN1AViral toolsNeuronal subtypesCerebral cortexViral manipulationTherapeutic interventionsVertebrate speciesNon-human primatesVirus vectorsGene expressionInterneuronsBrain regionsCircuit manipulationsExquisite specificityParvalbuminRegulatory landscapeNeuronsSCN1ASubtypesMice
2018
Molecular diversity underlying cortical excitatory and inhibitory synapse development
Favuzzi E, Rico B. Molecular diversity underlying cortical excitatory and inhibitory synapse development. Current Opinion In Neurobiology 2018, 53: 8-15. PMID: 29704699, DOI: 10.1016/j.conb.2018.03.011.Peer-Reviewed Original Research
2016
Shaping Early Networks to Rule Mature Circuits: Little MiRs Go a Long Way
Marques-Smith A, Favuzzi E, Rico B. Shaping Early Networks to Rule Mature Circuits: Little MiRs Go a Long Way. Neuron 2016, 92: 1154-1157. PMID: 28009269, DOI: 10.1016/j.neuron.2016.12.014.Peer-Reviewed Original Research
2014
Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis
Annibali D, Whitfield J, Favuzzi E, Jauset T, Serrano E, Cuartas I, Redondo-Campos S, Folch G, Gonzàlez-Juncà A, Sodir N, Massó-Vallés D, Beaulieu M, Swigart L, Mc Gee M, Somma M, Nasi S, Seoane J, Evan G, Soucek L. Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis. Nature Communications 2014, 5: 4632. PMID: 25130259, PMCID: PMC4143920, DOI: 10.1038/ncomms5632.Peer-Reviewed Original ResearchConceptsMYC inhibitionElevated MYC levelsPatient-derived tumorsAdult central nervous systemHuman glioblastoma cell linesCentral nervous systemFormation of multinucleated cellsPrimary tumorGlioblastoma cell linesStandard therapyOrthotopic xenograftsMYC levelsMouse modelIncreased apoptosisCancer therapyHuman tumorsMitotic catastropheTherapeutic strategiesHuman gliomasMYCTumorNervous systemInvasive astrocytomasGliomaCell lines
2011
The Action Mechanism of the Myc Inhibitor Termed Omomyc May Give Clues on How to Target Myc for Cancer Therapy
Savino M, Annibali D, Carucci N, Favuzzi E, Cole M, Evan G, Soucek L, Nasi S. The Action Mechanism of the Myc Inhibitor Termed Omomyc May Give Clues on How to Target Myc for Cancer Therapy. PLOS ONE 2011, 6: e22284. PMID: 21811581, PMCID: PMC3141027, DOI: 10.1371/journal.pone.0022284.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationCell SurvivalCells, CulturedDown-RegulationEpigenesis, GeneticFibroblastsHumansIntracellular SpaceMiceMolecular Targeted TherapyNeoplasmsPeptide FragmentsPromoter Regions, GeneticProtein BindingProtein TransportProteinsProto-Oncogene Proteins c-mycRatsRepressor ProteinsSerumTranscription, GeneticTranscriptional ActivationUp-RegulationConceptsMiz-1E-boxTargeting MYCProtein interactionsBinding to E-boxesMyc protein interactionsPromoter E-boxTransactivation of target genesBinding to promotersH3 lysine 9MYC interactomeHLH proteinsRepressed genesCancer therapyLysine 9Gene productsRNA interferenceCancer model in vivoOmomycEpigenetic changesTarget genesGene knockoutDecreased acetylationMYCN-myc