2020
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
Vormstein-Schneider D, Lin J, Pelkey K, Chittajallu R, Guo B, Arias-Garcia M, Allaway K, Sakopoulos S, Schneider G, Stevenson O, Vergara J, Sharma J, Zhang Q, Franken T, Smith J, Ibrahim L, Mastro K, Sabri E, Huang S, Favuzzi E, Burbridge T, Xu Q, Guo L, Vogel I, Sanchez V, Saldi G, Gorissen B, Yuan X, Zaghloul K, Devinsky O, Sabatini B, Batista-Brito R, Reynolds J, Feng G, Fu Z, McBain C, Fishell G, Dimidschstein J. Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans. Nature Neuroscience 2020, 23: 1629-1636. PMID: 32807948, PMCID: PMC8015416, DOI: 10.1038/s41593-020-0692-9.Peer-Reviewed Original ResearchConceptsRecombinant adeno-associated virus vectorAdeno-associated virus vectorVasoactive intestinal peptide-expressing interneuronsClasses of neuronsGene regulatory elementsGene SCN1AViral toolsNeuronal subtypesCerebral cortexViral manipulationTherapeutic interventionsVertebrate speciesNon-human primatesVirus vectorsGene expressionInterneuronsBrain regionsCircuit manipulationsExquisite specificityParvalbuminRegulatory landscapeNeuronsSCN1ASubtypesMice
2011
The Action Mechanism of the Myc Inhibitor Termed Omomyc May Give Clues on How to Target Myc for Cancer Therapy
Savino M, Annibali D, Carucci N, Favuzzi E, Cole M, Evan G, Soucek L, Nasi S. The Action Mechanism of the Myc Inhibitor Termed Omomyc May Give Clues on How to Target Myc for Cancer Therapy. PLOS ONE 2011, 6: e22284. PMID: 21811581, PMCID: PMC3141027, DOI: 10.1371/journal.pone.0022284.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationCell SurvivalCells, CulturedDown-RegulationEpigenesis, GeneticFibroblastsHumansIntracellular SpaceMiceMolecular Targeted TherapyNeoplasmsPeptide FragmentsPromoter Regions, GeneticProtein BindingProtein TransportProteinsProto-Oncogene Proteins c-mycRatsRepressor ProteinsSerumTranscription, GeneticTranscriptional ActivationUp-RegulationConceptsMiz-1E-boxTargeting MYCProtein interactionsBinding to E-boxesMyc protein interactionsPromoter E-boxTransactivation of target genesBinding to promotersH3 lysine 9MYC interactomeHLH proteinsRepressed genesCancer therapyLysine 9Gene productsRNA interferenceCancer model in vivoOmomycEpigenetic changesTarget genesGene knockoutDecreased acetylationMYCN-myc