2020
Detection of Immunogenic Cell Death in Tumor Vaccination Mouse Model
Tatsuno K, Han P, Edelson R, Hanlon D. Detection of Immunogenic Cell Death in Tumor Vaccination Mouse Model. Methods In Molecular Biology 2020, 2255: 171-186. PMID: 34033103, DOI: 10.1007/978-1-0716-1162-3_15.Peer-Reviewed Original ResearchConceptsImmunogenic cell deathTumor cellsImmune responseHigh mobility box 1Antitumor immune responseCell deathType I IFNVaccination assayTLR agonistsVivo vaccinationICD inducersICD inductionMouse modelI IFNBox 1Animal modelsGold standard methodPreparation of vaccinesMolecular patternsRegulated cell deathHallmark featureDeathIntracellular chaperoneCellsSurface translocation
2014
Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen
Saluja SS, Hanlon DJ, Sharp FA, Hong E, Khalil D, Robinson E, Tigelaar R, Fahmy TM, Edelson RL. Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen. International Journal Of Nanomedicine 2014, Volume 9: 5231-5246. PMID: 25419128, PMCID: PMC4235494, DOI: 10.2147/ijn.s66639.Peer-Reviewed Original Research
2002
Efficient Tumor Antigen Loading of Dendritic Antigen Presenting Cells by Transimmunization
Girardi M, Berger C, Hanlon D, Edelson RL. Efficient Tumor Antigen Loading of Dendritic Antigen Presenting Cells by Transimmunization. Technology In Cancer Research & Treatment 2002, 1: 65-69. PMID: 12614179, DOI: 10.1177/153303460200100109.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaMalignant T cellsT cellsTumor antigen loadingAnti-tumor immunityManagement of patientsT-cell lymphomaAntigen presenting cellsDendritic cell differentiationDendritic cellsSelective immunotherapyPresenting cellsOnly FDATumor antigensCell lymphomaAntigen loadingTumor cellsKey cellular eventsTransimmunizationImmunotherapyPatientsCancerRecent findingsEfficient phagocytosisCells