Replacing a Cysteine Ligand by Selenocysteine in a [NiFe]-Hydrogenase Unlocks Hydrogen Production Activity and Addresses the Role of Concerted Proton-Coupled Electron Transfer in Electrocatalytic Reversibility
Evans R, Krahn N, Weiss J, Vincent K, Söll D, Armstrong F. Replacing a Cysteine Ligand by Selenocysteine in a [NiFe]-Hydrogenase Unlocks Hydrogen Production Activity and Addresses the Role of Concerted Proton-Coupled Electron Transfer in Electrocatalytic Reversibility. Journal Of The American Chemical Society 2024, 146: 16971-16976. PMID: 38747098, PMCID: PMC11212049, DOI: 10.1021/jacs.4c03489.Peer-Reviewed Original ResearchProton-electron transferConcerted proton-coupled electron transferProton-coupled electron transferHydrogen production activityLowest energy pathwayProtein film voltammetryProton affinityReversible electrocatalystsSmall overpotentialProton reductionElectron transferProduction catalystsElectrocatalytic propertiesCysteine ligandsPlatinum metalsFilm voltammetryEnergy pathwaysProtonElectrocatalystsVoltammetryElectrocatalyticallyOverpotentialCatalystTransferCysteine