2022
Intra-amniotic Injection of Poly(lactic-co-glycolic Acid) Microparticles Loaded with Growth Factor: Effect on Tissue Coverage and Cellular Apoptosis in the Rat Model of Myelomeningocele.
Maassel NL, Wu DH, Yung NK, Bauer-Pisani T, Elizabeth Guerra M, Ullrich SJ, Mark Saltzman W, Stitelman DH. Intra-amniotic Injection of Poly(lactic-co-glycolic Acid) Microparticles Loaded with Growth Factor: Effect on Tissue Coverage and Cellular Apoptosis in the Rat Model of Myelomeningocele. Journal Of The American College Of Surgeons 2022, 234: 1010-1019. PMID: 35703790, DOI: 10.1097/xcs.0000000000000156.Peer-Reviewed Original ResearchConceptsSoft tissue coverageIntra-amniotic injectionFibroblast growth factorTissue coverageRat modelMMC defectsGrowth factorCellular apoptosisGestational day 17Spinal cord cellsSitu cell deathCell deathWild-type controlsHistologic evidenceTreatment optionsLifelong morbidityUtero treatmentNeurologic disordersRat damsCord cellsMyelomeningoceleDay 17Invasive platformIncidenceInjection
2021
A narrative review of in utero gene therapy: advances, challenges, and future considerations
Yung NK, Maassel NL, Ullrich SJ, Ricciardi AS, Stitelman DH. A narrative review of in utero gene therapy: advances, challenges, and future considerations. Translational Pediatrics 2021, 10: 1486496-1481496. PMID: 34189107, PMCID: PMC8192997, DOI: 10.21037/tp-20-89.Peer-Reviewed Original ResearchHighest effective doseGene therapyPathogenesis increasesLysosomal storage disorderImmune tolerancePostnatal treatmentTreatment optionsClinical trialsAnimal modelsCystic fibrosisFetal diagnosisNarrative reviewTranslational gapEffective doseUtero gene therapyPhysiologic phenomenonStorage disorderDiseaseNext-generation sequencingIUGTTechnologic advancementsCandidate diseaseClinical realmTherapyPotential disease