2023
Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2021
Frequency of Withdrawal of Life-Sustaining Therapy for Perceived Poor Neurologic Prognosis
Steinberg A, Abella BS, Gilmore EJ, Hwang DY, Kennedy N, Lau W, Mullen I, Ravishankar N, Tisch CF, Waddell A, Wallace DJ, Zhang Q, Elmer J. Frequency of Withdrawal of Life-Sustaining Therapy for Perceived Poor Neurologic Prognosis. Critical Care Explorations 2021, 3: e0487. PMID: 34278317, PMCID: PMC8280080, DOI: 10.1097/cce.0000000000000487.Peer-Reviewed Original ResearchPoor neurologic prognosisLife-sustaining therapyLarge teaching hospitalNeurologic prognosisOdds of withdrawalFrequency of withdrawalSmall Teaching HospitalTeaching hospitalMedian hospital lengthPrimary neurologic diagnosisRetrospective cohort studyRate of withdrawalInpatient decedentsHospital lengthInpatient deathCardiac deathCohort studyMedian ageHospital variabilitySignificant unexplained variationHospital characteristicsNeurologic diagnosisBrain deathNonteaching hospitalsHospital setting