The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury
Song L, Papaioannou G, Zhao H, Luderer H, Miller C, Dall’Osso C, Nazarian R, Wagers A, Demay M. The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury. Endocrinology 2016, 157: 4066-4075. PMID: 27526034, PMCID: PMC5045513, DOI: 10.1210/en.2016-1474.Peer-Reviewed Original ResearchConceptsVDR KO miceVitamin D receptorWild-type miceKO miceResident macrophagesM-CSFM-CSF gene expressionVitamin D receptor ablationM-CSF-induced proliferationVitamin D receptor knockoutVitamin D receptor statusInflammatory response to injuryMacrophage colony-stimulating factorColony-stimulating factorPeritoneal resident macrophagesRecruitment of macrophagesTissue resident macrophagesRegulation of innateLigand-dependent actionsLiganded vitamin D receptorResponse to injuryCyclin D1 expressionMacrophage self-renewalParabiosis studiesMacrophage defect