2016
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
Olenchock B, Moslehi J, Baik A, Davidson S, Williams J, Gibson W, Chakraborty A, Pierce K, Miller C, Hanse E, Kelekar A, Sullivan L, Wagers A, Clish C, Vander Heiden M, Kaelin W. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell 2016, 164: 884-895. PMID: 26919427, PMCID: PMC4819986, DOI: 10.1016/j.cell.2016.02.006.Peer-Reviewed Original ResearchConceptsRemote ischemic preconditioningIschemic preconditioningHypoxia-inducible factorKynurenic acidIschemic protectionMyocardial ischemia-reperfusion (I/R) injuryIschemia-reperfusion (I/R) injuryParabiosis experimentsPeriod of sublethal ischemiaMouse modelIschemic insultSecreted factorsPharmacological inhibitorsHepatic productionOther organsGene deletionSublethal ischemiaIschemiaMiceEGLN1Inhibition
2014
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
Katsimpardi L, Litterman N, Schein P, Miller C, Loffredo F, Wojtkiewicz G, Chen J, Lee R, Wagers A, Rubin L. Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors. Science 2014, 344: 630-634. PMID: 24797482, PMCID: PMC4123747, DOI: 10.1126/science.1251141.Peer-Reviewed Original ResearchConceptsAssociated with reduced blood flowImproved olfactory discriminationAdult central nervous systemDecline of neurogenesisAged mouse brainAge-related declineCentral nervous systemNegative effects of agingNeural stem cellsOlfactory discriminationAge-related decline of neurogenesisCognitive functionAged miceIncreased neurogenesisNeural stem cell behaviorVascular remodelingSecreted factorsEffects of ageEnhanced neurogenesisYoung bloodStem cellsStem cell behaviorBlood flowNeurogenic nicheNervous system