2016
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
Olenchock B, Moslehi J, Baik A, Davidson S, Williams J, Gibson W, Chakraborty A, Pierce K, Miller C, Hanse E, Kelekar A, Sullivan L, Wagers A, Clish C, Vander Heiden M, Kaelin W. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell 2016, 164: 884-895. PMID: 26919427, PMCID: PMC4819986, DOI: 10.1016/j.cell.2016.02.006.Peer-Reviewed Original ResearchConceptsRemote ischemic preconditioningIschemic preconditioningHypoxia-inducible factorKynurenic acidIschemic protectionMyocardial ischemia-reperfusion (I/R) injuryIschemia-reperfusion (I/R) injuryParabiosis experimentsPeriod of sublethal ischemiaMouse modelIschemic insultSecreted factorsPharmacological inhibitorsHepatic productionOther organsGene deletionSublethal ischemiaIschemiaMiceEGLN1Inhibition
2014
Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle
Sinha M, Jang Y, Oh J, Khong D, Wu E, Manohar R, Miller C, Regalado S, Loffredo F, Pancoast J, Hirshman M, Lebowitz J, Shadrach J, Cerletti M, Kim M, Serwold T, Goodyear L, Rosner B, Lee R, Wagers A. Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle. Science 2014, 344: 649-652. PMID: 24797481, PMCID: PMC4104429, DOI: 10.1126/science.1251152.Peer-Reviewed Original ResearchConceptsGDF11 levelsSystemic delivery of recombinant proteinsAged miceSkeletal muscleStem cell dysfunctionAged muscle stem cellsDelivery of recombinant proteinsMuscle stem cellsGrowth differentiation factor 11Differentiation factor 11Parabiosis experimentsSystemic deliveryMouse skeletal muscleImpaired regenerationSatellite cellsCell dysfunctionExercise capacityHeterochronic parabiosisYoung bloodStem cellsFactor 11Regenerative functionMiceMuscle agingRejuvenation factor
2013
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
Loffredo F, Steinhauser M, Jay S, Gannon J, Pancoast J, Yalamanchi P, Sinha M, Dall’Osso C, Khong D, Shadrach J, Miller C, Singer B, Stewart A, Psychogios N, Gerszten R, Hartigan A, Kim M, Serwold T, Wagers A, Lee R. Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy. Cell 2013, 153: 828-839. PMID: 23663781, PMCID: PMC3677132, DOI: 10.1016/j.cell.2013.04.015.Peer-Reviewed Original ResearchConceptsCardiac hypertrophyYoung miceOld miceCirculating factorsTreatment of old miceAge-related hypertrophyReduced cardiomyocyte sizeGrowth differentiation factor 11Aptamer-based proteomicsDifferentiation factor 11Blood-borne factorsReverse age-related cardiac hypertrophyCardiomyocyte sizeHeart failureSurgical techniqueHypertrophyCardiac agingHeterochronic parabiosisTherapeutic opportunitiesTGF-bFactor 11Influence of circulation factorsBehavioral effectsMiceMolecular remodeling