2015
Intrathymic transplantation of young, engraftable thymic epithelial cells promotes the growth and regeneration of the aging thymus (TRAN1P.932)
KIM M, Miller C, Shadrach J, Wagers A, Serwold T. Intrathymic transplantation of young, engraftable thymic epithelial cells promotes the growth and regeneration of the aging thymus (TRAN1P.932). The Journal Of Immunology 2015, 194: 140.14-140.14. DOI: 10.4049/jimmunol.194.supp.140.14.Peer-Reviewed Original ResearchThymic epithelial cellsEpithelial cellsAged thymusIntrathymic transplantationProliferative capacityIn vitro colony forming assayT-cell recoveryT-cell lymphopeniaBone marrow transplantationT cell productionAge-related thymic involutionCell-intrinsic changesColony forming assayThymic regrowthMarrow transplantationThymic regenerationMolecular processesT cellsCell engraftmentThymic involutionCirculating factorsThymic growthHeterochronic parabiosisThymic decline
2013
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
Loffredo F, Steinhauser M, Jay S, Gannon J, Pancoast J, Yalamanchi P, Sinha M, Dall’Osso C, Khong D, Shadrach J, Miller C, Singer B, Stewart A, Psychogios N, Gerszten R, Hartigan A, Kim M, Serwold T, Wagers A, Lee R. Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy. Cell 2013, 153: 828-839. PMID: 23663781, PMCID: PMC3677132, DOI: 10.1016/j.cell.2013.04.015.Peer-Reviewed Original ResearchConceptsCardiac hypertrophyYoung miceOld miceCirculating factorsTreatment of old miceAge-related hypertrophyReduced cardiomyocyte sizeGrowth differentiation factor 11Aptamer-based proteomicsDifferentiation factor 11Blood-borne factorsReverse age-related cardiac hypertrophyCardiomyocyte sizeHeart failureSurgical techniqueHypertrophyCardiac agingHeterochronic parabiosisTherapeutic opportunitiesTGF-bFactor 11Influence of circulation factorsBehavioral effectsMiceMolecular remodeling