Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses
Kim M, Miller C, Shadrach J, Wagers A, Serwold T. Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses. The Journal Of Immunology 2015, 194: 4784-4795. PMID: 25870244, PMCID: PMC4481326, DOI: 10.4049/jimmunol.1403158.Peer-Reviewed Original ResearchConceptsThymic epithelial cellsAge-related thymic involutionMolecular processesColony-forming assayAged thymusCell-intrinsic changesThymic growthProliferative capacityEpithelial cellsIn vitro colony-forming assayIncreased T cell productionT-cell recoveryT-cell lymphopeniaBone marrow transplantationT cell productionIntrathymic transplantation of young, engraftable thymic epithelial cells promotes the growth and regeneration of the aging thymus (TRAN1P.932)
KIM M, Miller C, Shadrach J, Wagers A, Serwold T. Intrathymic transplantation of young, engraftable thymic epithelial cells promotes the growth and regeneration of the aging thymus (TRAN1P.932). The Journal Of Immunology 2015, 194: 140.14-140.14. DOI: 10.4049/jimmunol.194.supp.140.14.Peer-Reviewed Original ResearchThymic epithelial cellsEpithelial cellsAged thymusIntrathymic transplantationProliferative capacityIn vitro colony forming assayT-cell recoveryT-cell lymphopeniaBone marrow transplantationT cell productionAge-related thymic involutionCell-intrinsic changesColony forming assayThymic regrowthMarrow transplantationThymic regenerationMolecular processesT cellsCell engraftmentThymic involutionCirculating factorsThymic growthHeterochronic parabiosisThymic decline