Chadi Abdallah, MD
Associate Professor Adjunct of PsychiatryCards
About
Research
Publications
2024
Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors?
Abdallah C, Tamman A. Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors? Expert Opinion On Therapeutic Targets 2024, 28: 651-653. PMID: 39099083, PMCID: PMC11357897, DOI: 10.1080/14728222.2024.2389201.Peer-Reviewed Original ResearchMedial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression
Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Rothman D, Abdallah C, Juchem C. Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression. NMR In Biomedicine 2024, 37: e5220. PMID: 39054694, DOI: 10.1002/nbm.5220.Peer-Reviewed Original ResearchPosttraumatic stress disorderMedial prefrontal cortexStress disorderPosttraumatic stress disorder patientsPosttraumatic stress disorder diagnosisChronic psychiatric conditionImpact of psychiatric comorbiditiesComorbid MDDPrefrontal cortexDepressive disorderTraumatic stressorsPsychiatric conditionsMDDPsychiatric comorbiditiesNeurotransmitter abnormalitiesConcentrations of glutamateMetabolite abnormalitiesHealthy controlsDisordersPattern of abnormalitiesParticipantsGlutamateIn vivo protonMetabolic abnormalitiesDepressionChallenges and rewards of in vivo synaptic density imaging, and its application to the study of depression
Asch R, Abdallah C, Carson R, Esterlis I. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression. Neuropsychopharmacology 2024, 1-11. PMID: 39039139, DOI: 10.1038/s41386-024-01913-3.Peer-Reviewed Original ResearchStudies of depressionAnimal models of chronic stressPositron emission tomographyModel of chronic stressSV2A imagingSynaptic densitySignificant depressive symptomsDevelopment of novel radiotracersDepressive symptomsNeuropsychiatric disordersSymptom severityChronic stressDrug challengeSynaptic vesicle glycoprotein 2 ANeural markersAnimal modelsSynaptic alterationsSynaptogenesis in vivoPreliminary findingsIn vivo quantificationCentral nervous systemDepressionEmission tomographySV2ASV2A positron emission tomographyMapping the Depressed Brain Under Stress Using Multimodal Neuroimaging
Akiki T, Abdallah C. Mapping the Depressed Brain Under Stress Using Multimodal Neuroimaging. American Journal Of Psychiatry 2024, 181: 578-580. PMID: 38946274, DOI: 10.1176/appi.ajp.20240400.Peer-Reviewed Original ResearchFindings of PTSD-specific deficits in default mode network strength following a mild experimental stressor
Averill C, Averill L, Akiki T, Fouda S, Krystal J, Abdallah C. Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor. NPP—Digital Psychiatry And Neuroscience 2024, 2: 9. PMID: 38919723, PMCID: PMC11197271, DOI: 10.1038/s44277-024-00011-y.Peer-Reviewed Original ResearchPosttraumatic stress disorderMajor depressive disorderConnectivity deficitsConnection strengthPrimary diagnosis of posttraumatic stress disorderExperimental stressorsDiagnosis of posttraumatic stress disorderResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingVentromedial prefrontal cortexDMN connectivity strengthStress-induced reductionEffect of groupDMN alterationsPrefrontal cortexDepressive disorderDMN connectivityStressor taskStress disorderBrain region(sAcute stressorFunctional connectivityDMNExploratory analysisDeficits366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders
Del Motte M, Tamman A, Jiang L, Averill C, Mason G, Averill L, Abdallah C. 366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders. Biological Psychiatry 2024, 95: s249. DOI: 10.1016/j.biopsych.2024.02.865.Peer-Reviewed Original ResearchUltrahigh-Field Magnetic Resonance Spectroscopy Findings Do Not Support Previous Brain Metabolite Findings in Major Depressive Disorder
Tamman A, Abdallah C. Ultrahigh-Field Magnetic Resonance Spectroscopy Findings Do Not Support Previous Brain Metabolite Findings in Major Depressive Disorder. Biological Psychiatry 2024, 95: 385-386. PMID: 38325915, DOI: 10.1016/j.biopsych.2023.12.022.Peer-Reviewed Original ResearchNeural differentiation of emotional faces as a function of interpersonal violence among adolescent girls
Tamman A, Abdallah C, Dunsmoor J, Cisler J. Neural differentiation of emotional faces as a function of interpersonal violence among adolescent girls. Journal Of Psychiatric Research 2024, 172: 90-101. PMID: 38368703, DOI: 10.1016/j.jpsychires.2024.02.015.Peer-Reviewed Original ResearchRepresentational similarity analysisInterpersonal violenceUnivariate activityNeutral facesFacial emotion processing taskEffects of trauma typeEmotion processing taskMultivoxel activity patternsMechanisms of riskFearful facesEmotional facesThreat processingFacial stimuliAbuse severityNeural alterationsPsychiatric diagnosisPsychiatric disordersTrauma typesPsychiatric medicationsRight hippocampusAssault severityNeural patternsPhysical assaultPhysical abuseUnique contributionsSmaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup
Huggins A, Baird C, Briggs M, Laskowitz S, Hussain A, Fouda S, Haswell C, Sun D, Salminen L, Jahanshad N, Thomopoulos S, Veltman D, Frijling J, Olff M, van Zuiden M, Koch S, Nawjin L, Wang L, Zhu Y, Li G, Stein D, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Suarez-Jimenez B, Zhu X, Kim Y, He X, Zilcha-Mano S, Lazarov A, Neria Y, Stevens J, Ressler K, Jovanovic T, van Rooij S, Fani N, Hudson A, Mueller S, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Říha P, Rektor I, Lebois L, Kaufman M, Olson E, Baker J, Rosso I, King A, Liberzon I, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Qi R, Lu G, Baugh L, Forster G, Simons R, Simons J, Magnotta V, Fercho K, Maron-Katz A, Etkin A, Cotton A, O’Leary E, Xie H, Wang X, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce S, Cisler J, Ross M, Herringa R, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Blackford J, Olatunji B, Kremen W, Lyons M, Franz C, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Dennis E, Tate D, Cifu D, Walker W, Wilde E, Harding I, Kerestes R, Thompson P, Morey R. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. Molecular Psychiatry 2024, 29: 611-623. PMID: 38195980, PMCID: PMC11153161, DOI: 10.1038/s41380-023-02352-0.Peer-Reviewed Original ResearchCorrection: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2024, 49: 764-764. PMID: 38182778, PMCID: PMC10876612, DOI: 10.1038/s41386-023-01786-y.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News & Links
News
- January 04, 2021
Three Yale-Led Studies Named Leading Research Achievements by BBRF
- April 04, 2019Source: Psychiatric Times
Ketamine for stress-related psychopathology and suicidality: A brief update
- April 16, 2018
What's in a name? Yale researchers track PTSD's many identities during war
- September 15, 2016
Anticevic Lab collaborates on neuroimaging study examining treatment in major depression.