2024
Exposures to Artificial Light at Night and Ambient Fine Particulate Matter and Risk of Pediatric Papillary Thyroid Cancer
Deziel N, Wang R, Warren J, Dinauer C, Ogilvie J, Clark C, Zhong C, Wiemels J, Morimoto L, Metayer C, Ma X. Exposures to Artificial Light at Night and Ambient Fine Particulate Matter and Risk of Pediatric Papillary Thyroid Cancer. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0720.Peer-Reviewed Original ResearchMolecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules
Spaulding S, Maayah M, Dinauer C, Prasad M, Darbinyan A, Morotti R, Christison-Lagay E. Molecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules. Journal Of Pediatric Surgery 2024, 59: 975-980. PMID: 38246817, DOI: 10.1016/j.jpedsurg.2024.01.001.Peer-Reviewed Original ResearchFine-needle aspiration biopsyPediatric thyroid nodulesMolecular genetic testingBethesda IV nodulesPrediction of malignancyDICER1 mutationsThyroid nodulesGenetic testingNRAS mutationsMethods Retrospective chart reviewRetrospective chart reviewTime of surgeryBRAF V600E testingMutations/fusionsBethesda III nodulesChart reviewSurgical resectionFinal histopathologyThyroid resectionPediatric dataHistologic classificationSurgical specimensBRAF mutationsAspiration biopsyCytopathologic evaluation
2022
Differences in the management of thyroid nodules in children and adolescents as compared to adults
Goldfarb M, Dinauer C. Differences in the management of thyroid nodules in children and adolescents as compared to adults. Current Opinion In Endocrinology Diabetes And Obesity 2022, 29: 466-473. PMID: 35777975, DOI: 10.1097/med.0000000000000754.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPediatric thyroid nodulesThyroid nodulesFine-needle aspiration biopsyRisk of malignancyRisk stratification systemSpecific risk factorsAppropriate imaging modalityNeedle aspiration biopsyCertain genetic syndromesYounger patientsNonoperative approachClinical managementRadiofrequency ablationRisk factorsPretest probabilityAspiration biopsyMiRNA classifierSpecific molecular testsMolecular testingUltrasound characteristicsAge groupsGenetic syndromesClinical usePatientsBenign nodulesTreatment of hypothyroidism in infants, children and adolescents
Rodriguez L, Dinauer C, Francis G. Treatment of hypothyroidism in infants, children and adolescents. Trends In Endocrinology And Metabolism 2022, 33: 522-532. PMID: 35537910, DOI: 10.1016/j.tem.2022.04.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTreatment of hypothyroidismLow birth weightBirth weightCongenital hypothyroidismNormal thyrotropin levelsAmerican Thyroid AssociationSubset of childrenSubclinical hypothyroidismThyrotropin levelsTreatment guidelinesThyroid AssociationHypothyroidismTreatmentChildrenDiagnosisPreferred methodLevothyroxineGeneral consensusObesityInfantsSyndrome
2021
Management of Pediatric Graves Disease
Quintanilla-Dieck L, Khalatbari HK, Dinauer CA, Rastatter JC, Chelius DC, Katowitz WR, Shindo ML, Parisi MT, Kazahaya K. Management of Pediatric Graves Disease. JAMA Otolaryngology - Head & Neck Surgery 2021, 147: 1110-1118. PMID: 34647991, DOI: 10.1001/jamaoto.2021.2715.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGraves' diseaseClinical presenting signsPediatric Graves' diseaseSustained remission rateRadioactive iodine therapyFirst-line treatmentSpecific clinical characteristicsMultidisciplinary approachIodine therapyRemission rateClinical characteristicsDefinitive treatmentMedical therapyPediatric patientsPresenting signMedical managementPediatric populationAntithyroid drugsTherapeutic optionsCertain patientsTreatment optionsOptimal treatmentThyroid ultrasonographyPediatric expertsNuclear medicine
2020
A Comparison of the Differences Between Dutch and American Thyroid Association Guidelines for the Management of Pediatric Thyroid Cancer
Dinauer C. A Comparison of the Differences Between Dutch and American Thyroid Association Guidelines for the Management of Pediatric Thyroid Cancer. Clinical Thyroidology 2020, 32: 525-528. DOI: 10.1089/ct.2020;32.525-528.Commentaries, Editorials and LettersCytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology–histopathology correlation in 7 patients
Darbinyan A, Morotti R, Cai G, Prasad ML, Christison‐Lagay E, Dinauer C, Adeniran AJ. Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology–histopathology correlation in 7 patients. Cancer Cytopathology 2020, 128: 746-756. PMID: 32897650, DOI: 10.1002/cncy.22329.Peer-Reviewed Original ResearchConceptsDICER1 mutationsThyroid diseaseThyroid carcinomaScreening of patientsFine-needle aspiration samplesMonitoring of patientsDiagnostic cytologic featuresPapillary thyroid carcinomaGermline DICER1 mutationsThyroid fine-needle aspiration samplesFNA evaluationUndetermined significanceDifferent somatic variantsThyroid cancerScant colloidNeoplastic lesionsHistopathological analysisCytomorphologic featuresDICER1 syndromeModerate cellularityCytologic featuresFollicular carcinomaFollicular lesionsInconspicuous nucleoliFollicular neoplasmTotal Thyroidectomy Remains Appropriate as Initial Treatment for Children with Papillary Thyroid Cancer That Frequently Harbors Occult Bilateral Disease
Dinauer C. Total Thyroidectomy Remains Appropriate as Initial Treatment for Children with Papillary Thyroid Cancer That Frequently Harbors Occult Bilateral Disease. Clinical Thyroidology 2020, 32: 333-336. DOI: 10.1089/ct.2020;32.333-336.Commentaries, Editorials and LettersPediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee
Christison-Lagay ER, Baertschiger RM, Dinauer C, Francis G, Malek M, Lautz T, Aldrink J, Grant C, Rhee D, Ehrlich P, Dasgupta R, Abdessalam S, Committee O. Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee. Journal Of Pediatric Surgery 2020, 55: 2273-2283. PMID: 32553450, DOI: 10.1016/j.jpedsurg.2020.05.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsThyroid cancerPediatric DTCAPSA Cancer CommitteeSurgical therapeutic approachUnresectable progressive diseaseLymph node basinCornerstone of treatmentAutoimmune thyroid diseaseLong-term recurrenceFine-needle aspirationNode basinTotal thyroidectomyProgressive diseaseSurgical resectionRadiological featuresSurvival outcomesCancer CommitteeThyroid diseaseTreatment strategiesFamily historyTreatment decisionsNeedle aspirationTherapeutic approachesThyroid carcinomaIodine deficiency“A Real Pain in the Neck”
Joseph K, Dinauer C. “A Real Pain in the Neck”. Clinical Thyroidology 2020, 32: 251-254. DOI: 10.1089/ct.2020;32.251-254.Peer-Reviewed Case Reports and Technical NotesLarge-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature
Gummadavelli A, Dinauer C, McGuone D, Vining EM, Erson-Omay EZ, Omay SB. Large-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature. Journal Of Clinical Neuroscience 2020, 78: 420-422. PMID: 32336638, DOI: 10.1016/j.jocn.2020.04.103.Peer-Reviewed Original ResearchPostoperative Preablation TSH-Stimulated Thyroglobulin May Predict Outcome of Differentiated Thyroid Cancer in Children
Dinauer C. Postoperative Preablation TSH-Stimulated Thyroglobulin May Predict Outcome of Differentiated Thyroid Cancer in Children. Clinical Thyroidology 2020, 32: 131-134. DOI: 10.1089/ct.2020;32.131-134.Commentaries, Editorials and LettersRecurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice
Rubinstein JC, Herrick-Reynolds K, Dinauer C, Morotti R, Solomon D, Callender GG, Christison-Lagay ER. Recurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice. Journal Of Surgical Research 2020, 249: 58-66. PMID: 31923715, DOI: 10.1016/j.jss.2019.12.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsChildFemaleFollow-Up StudiesHospitals, High-VolumeHumansLymph NodesLymphatic MetastasisMaleNeoplasm Recurrence, LocalPostoperative ComplicationsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsSurvival AnalysisThyroid Cancer, PapillaryThyroid GlandThyroid NeoplasmsThyroidectomyTreatment OutcomeYoung AdultConceptsPediatric papillary thyroid cancerLateral neck diseaseNeck diseasePapillary thyroid cancerNode involvementThyroid cancerExact testLymph node involvementCentral neck dissectionExtent of diseasePredictors of recurrenceRetrospective case seriesNon-Caucasian raceCox proportional hazardsLateral node involvementHigh-volume practiceFisher's exact testDisease recurrenceLymphovascular invasionMedian ageNeck dissectionCase seriesIndependent predictorsRetrospective reviewTumor sizeThe Block-and-Replace Method May Have a Role in the Management of Pediatric Graves’ Disease
Dinauer C. The Block-and-Replace Method May Have a Role in the Management of Pediatric Graves’ Disease. Clinical Thyroidology 2020, 32: 17-19. DOI: 10.1089/ct.2020;32.17-19.Commentaries, Editorials and Letters
2019
Children with Autoimmune Thyroid Disease Are at Increased Risk for Autoimmune Gastritis
Dinauer C. Children with Autoimmune Thyroid Disease Are at Increased Risk for Autoimmune Gastritis. Clinical Thyroidology 2019, 31: 463-466. DOI: 10.1089/ct.2019;31.463-466.Commentaries, Editorials and LettersThe Hypothalamic–Pituitary–Thyroid Axis Matures Earlier in Girls than in Boys
Dinauer C. The Hypothalamic–Pituitary–Thyroid Axis Matures Earlier in Girls than in Boys. Clinical Thyroidology 2019, 31: 365-367. DOI: 10.1089/ct.2019;31.365-367.Commentaries, Editorials and LettersComplication Rates for Pediatric Thyroid Surgery Are Lower at Higher-Volume U.S. Hospitals
Dinauer C. Complication Rates for Pediatric Thyroid Surgery Are Lower at Higher-Volume U.S. Hospitals. Clinical Thyroidology 2019, 31: 237-239. DOI: 10.1089/ct.2019;31.237-239.Commentaries, Editorials and LettersMalignancy Rates in Cytologically Indeterminate Thyroid Nodules among Children Are Lower Than Previously Reported but Remain Higher Than in Adults
Dinauer C. Malignancy Rates in Cytologically Indeterminate Thyroid Nodules among Children Are Lower Than Previously Reported but Remain Higher Than in Adults. Clinical Thyroidology 2019, 31: 158-161. DOI: 10.1089/ct.2019;31.158-161.Commentaries, Editorials and LettersThe Value of Thyroid-Function Testing in the Pediatric Inpatient Setting Is Low
Dinauer C. The Value of Thyroid-Function Testing in the Pediatric Inpatient Setting Is Low. Clinical Thyroidology 2019, 31: 52-54. DOI: 10.1089/ct.2019;31.52-54.Commentaries, Editorials and Letters
2018
Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer
Rubinstein JC, Dinauer C, Herrick-Reynolds K, Morotti R, Callender GG, Christison-Lagay ER. Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer. Journal Of Pediatric Surgery 2018, 54: 129-132. PMID: 30361076, DOI: 10.1016/j.jpedsurg.2018.10.010.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerPediatric patientsTotal thyroidectomyNeck dissectionThyroid cancerN1b papillary thyroid cancerPediatric papillary thyroid cancerProphylactic central neck dissectionRegional lymph node metastasisCentral neck dissectionRetrospective case seriesLymph node metastasisRadical neck dissectionTime of presentationLikelihood of recurrenceTime of operationMedian ageMedian durationMetastatic LNsNode metastasisCase seriesPediatric populationPrognostic predictorSingle institutionSingle recurrence