2022
Differences in the management of thyroid nodules in children and adolescents as compared to adults
Goldfarb M, Dinauer C. Differences in the management of thyroid nodules in children and adolescents as compared to adults. Current Opinion In Endocrinology Diabetes And Obesity 2022, 29: 466-473. PMID: 35777975, DOI: 10.1097/med.0000000000000754.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPediatric thyroid nodulesThyroid nodulesFine-needle aspiration biopsyRisk of malignancyRisk stratification systemSpecific risk factorsAppropriate imaging modalityNeedle aspiration biopsyCertain genetic syndromesYounger patientsNonoperative approachClinical managementRadiofrequency ablationRisk factorsPretest probabilityAspiration biopsyMiRNA classifierSpecific molecular testsMolecular testingUltrasound characteristicsAge groupsGenetic syndromesClinical usePatientsBenign nodules
2010
Adverse Events Associated with Methimazole Therapy of Graves' Disease in Children
Rivkees SA, Stephenson K, Dinauer C. Adverse Events Associated with Methimazole Therapy of Graves' Disease in Children. International Journal Of Pediatric Endocrinology 2010, 2010: 176970. PMID: 20224800, PMCID: PMC2833412, DOI: 10.1155/2010/176970.Peer-Reviewed Original ResearchAdverse eventsGraves' diseaseSide effectsGraves' disease therapyWeeks of therapyStevens-Johnson syndromeCommon side effectsConsecutive pediatric patientsMajor side effectsDisease therapyAverage daily doseAntithyroid medicationDiffuse arthralgiaMethimazole therapyMMI useCholestatic jaundiceJoint painPatient ageDaily dosePediatric patientsPediatric populationCommon causePatientsMedicationsDisease
2008
Differentiated thyroid cancer in children: diagnosis and management
Dinauer CA, Breuer C, Rivkees SA. Differentiated thyroid cancer in children: diagnosis and management. Current Opinion In Oncology 2008, 20: 59-65. PMID: 18043257, DOI: 10.1097/cco.0b013e3282f30220.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferentiated thyroid cancerThyroid cancerOptimal treatmentDifferentiated thyroid cancer treatmentPediatric thyroid cancerLymph node dissectionTime of diagnosisLarge case seriesCommon endocrine malignancyThyroid cancer treatmentAdvanced diseaseTotal thyroidectomyAdult patientsRemnant ablationYounger patientsPediatric patientsCase seriesSurgical approachFavorable outcomeEndocrine malignancyUnusual diseaseClinical approachRadioactive iodineCancerPatients
2007
Thyroid Cancer in Children
Dinauer C, Francis GL. Thyroid Cancer in Children. Endocrinology And Metabolism Clinics Of North America 2007, 36: 779-806. PMID: 17673128, DOI: 10.1016/j.ecl.2007.04.002.ChaptersConceptsDetectable serum thyroglobulinThyroid cancerSerum thyroglobulinNegative whole-body scanNegative imaging studiesManagement of childrenChildhood thyroid cancerRobust immune responseWhole-body scanYears of ageHigh-risk categoryGrowth factor expression patternsRecurrent diseaseUncommon tumorCurrent guidelinesImmune responseHigh riskImaging studiesCancerUnique subsetGenetic mutationsLimited dataChildrenPatientsThyroglobulin
2004
The MACIS Score Predicts the Clinical Course of Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Francis GL. The MACIS Score Predicts the Clinical Course of Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2004, 17: 339-344. PMID: 15112910, DOI: 10.1515/jpem.2004.17.3.339.Peer-Reviewed Original Research
2003
Treatment of Recurrent Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Francis GL. Treatment of Recurrent Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2003, 16: 1033-1040. PMID: 14513881, DOI: 10.1515/jpem.2003.16.7.1033.Peer-Reviewed Original ResearchConceptsRecurrent papillary thyroid carcinomaPapillary thyroid carcinomaThyroid carcinomaYears of ageThird remissionCervical nodesPersistent diseaseClinical coursePoor prognosisSecond recurrenceHigh mortalityRemissionChildrenCarcinomaRecurrenceMortalityTreatmentAdultsPrevious dataPatientsPrognosisDiseaseTumor Size and Extent of Disease at Diagnosis Predict the Response to Initial Therapy for Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Robie DK, McClellan DR, Francis GL. Tumor Size and Extent of Disease at Diagnosis Predict the Response to Initial Therapy for Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2003, 16: 693-702. PMID: 12880118, DOI: 10.1515/jpem.2003.16.5.693.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaExtent of diseaseLarger tumor sizeTumor sizeExtensive diseaseInitial treatmentThyroid carcinomaRadioactive iodine treatmentClass IV patientsInitial therapyFirst remissionIV patientsPersistent diseaseMultifocal diseasePatientsClass IIIRemissionClass IIIodine treatmentDiseaseClass IDiagnosisTreatmentCarcinomaChildren
1999
Ras mutations are uncommon in sporadic thyroid cancer in children and young adults
Fenton C, Anderson J, Lukes Y, Dinauer C, Tuttle RM, Francis GL. Ras mutations are uncommon in sporadic thyroid cancer in children and young adults. Journal Of Endocrinological Investigation 1999, 22: 781-789. PMID: 10614528, DOI: 10.1007/bf03343644.Peer-Reviewed Original ResearchConceptsMedullary thyroid cancerFollicular thyroid cancerChildhood thyroid cancerThyroid cancerPrevious radiation exposureRas mutationsRadiation exposureCodon 12Aggressive papillary thyroid cancerAdult thyroid cancerClass II diseaseSporadic thyroid cancerPapillary thyroid cancerArchival tissue blocksLung metastasesCancer 4Number of subjectsPatientsCancerLymphomaYoung adultsTissue blocksHuman cancersChildrenPrevious reports
1998
Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults
Dinauer C, Tuttle M, Robie D, McClellan D, Svec R, Adair C, Francis G. Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults. Clinical Endocrinology 1998, 49: 619-628. PMID: 10197078, DOI: 10.1046/j.1365-2265.1998.00584.x.Peer-Reviewed Original ResearchConceptsDifferentiated thyroid cancerThyroid cancerClinical featuresMultifocal tumorsCases of FTCPalpable cervical lymphadenopathyRisk of recurrenceYears of ageCases of PTCCervical lymphadenopathyDistant recurrenceYounger patientsTumor RegistryFTC groupPathological findingsRetrospective studyLarge tumorsUnivariate analysisFollicular variantPTC groupHigh riskPatientsRecurrenceLower mortalityGreater risk