2024
Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design
Gross R, Thaweethai T, Rosenzweig E, Chan J, Chibnik L, Cicek M, Elliott A, Flaherman V, Foulkes A, Witvliet M, Gallagher R, Gennaro M, Jernigan T, Karlson E, Katz S, Kinser P, Kleinman L, Lamendola-Essel M, Milner J, Mohandas S, Mudumbi P, Newburger J, Rhee K, Salisbury A, Snowden J, Stein C, Stockwell M, Tantisira K, Thomason M, Truong D, Warburton D, Wood J, Ahmed S, Akerlundh A, Alshawabkeh A, Anderson B, Aschner J, Atz A, Aupperle R, Baker F, Balaraman V, Banerjee D, Barch D, Baskin-Sommers A, Bhuiyan, Bind M, Bogie A, Bradford T, Buchbinder N, Bueler E, Bükülmez H, Casey B, Chang L, Chrisant M, Clark D, Clifton R, Clouser K, Cottrell L, Cowan K, D’Sa V, Dapretto M, Dasgupta S, Dehority W, Dionne A, Dummer K, Elias M, Esquenazi-Karonika S, Evans D, Faustino E, Fiks A, Forsha D, Foxe J, Friedman N, Fry G, Gaur S, Gee D, Gray K, Handler S, Harahsheh A, Hasbani K, Heath A, Hebson C, Heitzeg M, Hester C, Hill S, Hobart-Porter L, Hong T, Horowitz C, Hsia D, Huentelman M, Hummel K, Irby K, Jacobus J, Jacoby V, Jone P, Kaelber D, Kasmarcak T, Kluko M, Kosut J, Laird A, Landeo-Gutierrez J, Lang S, Larson C, Lim P, Lisdahl K, McCrindle B, McCulloh R, McHugh K, Mendelsohn A, Metz T, Miller J, Mitchell E, Morgan L, Müller-Oehring E, Nahin E, Neale M, Ness-Cochinwala M, Nolan S, Oliveira C, Osakwe O, Oster M, Payne R, Portman M, Raissy H, Randall I, Rao S, Reeder H, Rosas J, Russell M, Sabati A, Sanil Y, Sato A, Schechter M, Selvarangan R, Tejtel S, Shakti D, Sharma K, Squeglia L, Srivastava S, Stevenson M, Szmuszkovicz J, Talavera-Barber M, Teufel R, Thacker D, Trachtenberg F, Udosen M, Warner M, Watson S, Werzberger A, Weyer J, Wood M, Yin H, Zempsky W, Zimmerman E, Dreyer B, Consortium O. Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design. PLOS ONE 2024, 19: e0285635. PMID: 38713673, PMCID: PMC11075869, DOI: 10.1371/journal.pone.0285635.Peer-Reviewed Original ResearchConceptsYoung adultsClinical courseAdolescent Brain Cognitive DevelopmentCaregiver-child pairsLong-term outcomesObservational cohort studyOutcomes of COVID-19De novo cohortAdolescent Brain Cognitive Development StudySociodemographic correlatesCommunity partnersBaseline assessmentLongitudinal follow-upPotential therapeutic interventionsPediatric protocolsCohort studyCollaborative partnershipsProspective cohortFollow-upStudy protocolFederal partnersNIH Researching COVIDLong-term outcomes of COVID-19Enhanced recoveryData collectionGuidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce
Willis Z, Oliveira C, Abzug M, Anosike B, Ardura M, Bio L, Boguniewicz J, Chiotos K, Downes K, Grapentine S, Hersh A, Heston S, Hijano D, Huskins W, James S, Jones S, Lockowitz C, Lloyd E, MacBrayne C, Maron G, McDonough M, Miller C, Morton T, Olivero R, Orscheln R, Schwenk H, Singh P, Soma V, Sue P, Vora S, Nakamura M, Wolf J. Guidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce. Journal Of The Pediatric Infectious Diseases Society 2024, 13: 159-185. PMID: 38339996, DOI: 10.1093/jpids/piad116.Peer-Reviewed Original ResearchConceptsRisk factorsRisk stratificationPediatric intensive care medicineEffects of therapyNon-hospitalized childrenPediatric infectious diseasesSevere COVID-19Cases of infectionMeta-analysis of dataIntensive care medicineClinical characteristicsPreventive therapyPediatric populationManagement of COVID-19Fatal infectionConsensus statementSevere illnessTherapyMeta-analysisTherapeutic interventionsSARS-CoV-2Expert consensusCare medicineRe-convenedGuidance statements
2023
Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review
Ellingson M, Sheikha H, Nyhan K, Oliveira C, Niccolai L. Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review. Human Vaccines & Immunotherapeutics 2023, 19: 2239085. PMID: 37529935, PMCID: PMC10399474, DOI: 10.1080/21645515.2023.2239085.Peer-Reviewed Original ResearchConceptsVaccine effectivenessSystematic reviewHuman Papillomavirus Vaccine EffectivenessVaccine-type HPV infectionYounger ageHigh vaccine effectivenessHuman papillomavirus vaccineVaccine effectiveness studiesYounger age groupsAdolescents ages 15Adolescents ages 9HPV infectionHPV vaccineVaccine initiationPapillomavirus vaccineTime vaccinationAnogenital wartsCervical abnormalitiesCervical cancerDisease outcomeAge groupsOlder ageEffectiveness studiesAge 15Age
2022
Assessment of Clinical Effectiveness of BNT162b2 COVID-19 Vaccine in US Adolescents
Oliveira CR, Niccolai LM, Sheikha H, Elmansy L, Kalinich CC, Grubaugh ND, Shapiro ED, Billig K, Breban M, Brito A, Earnest R, Fauver J, Koch T, Ott I, Petrone M, Vogels C, Pham K, Tikhonova I, Castaldi C, Mane S, Bilguvar K, De Kumar B, Ferguson D, Kerantzas N, Landry M, Peaper D, Schulz W. Assessment of Clinical Effectiveness of BNT162b2 COVID-19 Vaccine in US Adolescents. JAMA Network Open 2022, 5: e220935. PMID: 35238933, PMCID: PMC8895259, DOI: 10.1001/jamanetworkopen.2022.0935.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionCase-control studyVaccine effectivenessBNT162b2 vaccineSARS-CoV-2Medical recordsAsymptomatic SARS-CoV-2 infectionBNT162b2 COVID-19 vaccineRetrospective case-control studyRT-PCR test resultsSARS-CoV-2 testUS adolescentsReverse transcription polymerase chain reaction testConditional logistic regression modelsTranscription polymerase chain reaction testDoses of vaccineControl participantsClinical trial populationsRelevant clinical dataCase participantsCOVID-19 vaccinePositive test resultsChain reaction testCounty of residenceNegative test resultsUpdated Guidance on Use and Prioritization of Monoclonal Antibody Therapy for Treatment of COVID-19 in Adolescents
Wolf J, Abzug MJ, Anosike BI, Vora SB, Waghmare A, Sue PK, Olivero RM, Oliveira CR, James SH, Morton TH, Maron GM, Young JL, Orscheln RC, Schwenk HT, Bio LL, Willis ZI, Lloyd EC, Hersh AL, Huskins CW, Soma VL, Ratner AJ, Hayes M, Downes K, Chiotos K, Grapentine SP, Wattier RL, Lamb GS, Zachariah P, Nakamura MM. Updated Guidance on Use and Prioritization of Monoclonal Antibody Therapy for Treatment of COVID-19 in Adolescents. Journal Of The Pediatric Infectious Diseases Society 2022, 11: 177-185. PMID: 35107571, PMCID: PMC8903349, DOI: 10.1093/jpids/piab124.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMonoclonal antibody therapyPediatric infectious diseasesAntibody therapyEmergency use authorizationSevere diseasePostexposure prophylaxisHigh riskCOVID-19Severe acute respiratory syndrome coronavirus 2Certain high-risk conditionsSpecific monoclonal antibody therapyAcute respiratory syndrome coronavirus 2Infectious diseasesRespiratory syndrome coronavirus 2Moderate COVID-19Pediatric critical care medicineSyndrome coronavirus 2Coronavirus disease 2019Critical care medicineHigh-risk conditionsSeries of teleconferencesHigh-risk exposureBamlanivimab monotherapyInfusion reactionsControlled TrialsState Laws Permitting Adolescent Consent to Human Papillomavirus Vaccination and Rates of Immunization
Torres AR, Johnson NP, Ellingson MK, Hansen CE, Oliveira CR, Niccolai LM, Sheth SS. State Laws Permitting Adolescent Consent to Human Papillomavirus Vaccination and Rates of Immunization. JAMA Pediatrics 2022, 176: 203-205. PMID: 34779839, PMCID: PMC8593826, DOI: 10.1001/jamapediatrics.2021.4591.Peer-Reviewed Original Research
2021
Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States
Hosier H, Sheth SS, Oliveira CR, Perley LE, Vash-Margita A. Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States. American Journal Of Obstetrics And Gynecology 2021, 225: 649.e1-649.e9. PMID: 34256029, PMCID: PMC8633062, DOI: 10.1016/j.ajog.2021.07.005.Peer-Reviewed Original ResearchConceptsCervical cancerLarge healthcare systemYears of ageIncidence rateScreening testAdolescent femalesHealthcare systemLarge multihospital health systemCervical cancer screening resultsNew cervical cancer casesCurrent consensus recommendationsHuman papillomavirus testingHuman papillomavirus vaccinationCervical cancer casesCervical cancer screeningMultihospital health systemCancer risk reductionScreening resultsPoisson regression analysisEvidence-based strategiesGuideline nonadherencePapillomavirus vaccinationCytology testingIntraepithelial lesionsProvider factorsThe clinical epidemiology of coronavirus disease 2019 in children and adolescents mirrors the widening gap in healthcare disparities
Zirinsky E, Paintsil E, Oliveira CR. The clinical epidemiology of coronavirus disease 2019 in children and adolescents mirrors the widening gap in healthcare disparities. Current Opinion In Pediatrics 2021, 33: 281-285. PMID: 33871422, PMCID: PMC8635086, DOI: 10.1097/mop.0000000000001018.Commentaries, Editorials and LettersMeSH KeywordsAdolescentChildCOVID-19Healthcare DisparitiesHispanic or LatinoHumansPandemicsSARS-CoV-2ConceptsClinical epidemiologyRespiratory diseaseSARS-CoV-2-related deathAcute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemicSevere lower respiratory diseaseHealth disparitiesSARS-CoV-2 infectionLongstanding health disparitiesKawasaki-like syndromeLower respiratory diseaseCoronavirus 2 pandemicCoronavirus disease 2019Upper respiratory diseaseSARS-CoV-2Ethnic health disparitiesPandemics/epidemicsCardiovascular shockInfluenza seasonDisease 2019Healthcare disparitiesUS populationEthnic disparitiesHispanic childrenMore childrenInpatient Immunization With HPV Vaccine: A Qualitative Study With Postpartum Women
Avni-Singer L, Oliveira CR, Torres A, Shapiro ED, Niccolai LM, Sheth SS. Inpatient Immunization With HPV Vaccine: A Qualitative Study With Postpartum Women. Women's Health Issues 2021, 31: 384-391. PMID: 33715924, PMCID: PMC8260440, DOI: 10.1016/j.whi.2021.02.002.Peer-Reviewed Original ResearchConceptsHPV vaccinePostpartum womenPatient-centered approachHPV immunization programHuman papillomavirus vaccineRates of immunizationIterative thematic approachYoung adult femalesInpatient immunizationHospital dischargePapillomavirus vaccinePostpartum patientsMedian ageImmunization programsPatient's perspectiveProgram implementationVaccine hesitancyImmunizationVaccineWomenQualitative studyThematic approachPatientsHospitalAdult femalesInitial Guidance on Use of Monoclonal Antibody Therapy for Treatment of Coronavirus Disease 2019 in Children and Adolescents
Wolf J, Abzug MJ, Wattier RL, Sue PK, Vora SB, Zachariah P, Dulek DE, Waghmare A, Olivero R, Downes KJ, James SH, Pinninti SG, Yarbrough A, Aldrich ML, MacBrayne CE, Soma VL, Grapentine SP, Oliveira CR, Hayes M, Kimberlin DW, Jones SB, Bio LL, Morton TH, Hankins JS, Marόn-Alfaro G, Timberlake K, Young JL, Orscheln RC, Schwenk HT, Goldman DL, Groves HE, Huskins WC, Rajapakse NS, Lamb GS, Tribble AC, Lloyd E, Hersh AL, Thorell EA, Ratner AJ, Chiotos K, Nakamura MM. Initial Guidance on Use of Monoclonal Antibody Therapy for Treatment of Coronavirus Disease 2019 in Children and Adolescents. Journal Of The Pediatric Infectious Diseases Society 2021, 10: 629-634. PMID: 33388760, PMCID: PMC7799019, DOI: 10.1093/jpids/piaa175.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMonoclonal antibody therapyHigh-risk groupAntibody therapyEmergency use authorizationCOVID-19Moderate coronavirus disease 2019Pediatric intensive care medicinePediatric-specific evidenceTreatment of mildPediatric infectious diseasesHigh-quality evidenceCoronavirus disease 2019Intensive care medicineSeries of teleconferencesREGN-COV2Infusion reactionsPediatric HematologyTimely administrationRisk factorsRoutine administrationDisease 2019Severe diseaseCare medicineHigh riskModest benefit
2020
Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Children in a Large Regional US Health System During the Coronavirus Disease 2019 Pandemic.
Peaper DR, Murdzek C, Oliveira CR, Murray TS. Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Children in a Large Regional US Health System During the Coronavirus Disease 2019 Pandemic. The Pediatric Infectious Disease Journal 2020, 40: 175-181. PMID: 33399431, PMCID: PMC8852689, DOI: 10.1097/inf.0000000000003024.Peer-Reviewed Original ResearchConceptsYale New Haven Health SystemSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Subset of childrenPediatric casesHealth systemCycle threshold valuesCoronavirus 2Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNACross-sectional time-series studyCoronavirus disease 2019 (COVID-19) testingPositive pediatric casesSimilar cycle threshold valuesCoronavirus disease 2019 (COVID-19) pandemicUpper respiratory tractCoronavirus disease 2019Large health systemYears of ageDisease 2019 pandemicUS health systemAmbulatory locationsVirology resultsAsymptomatic childrenSevere Acute Respiratory Syndrome Coronavirus 2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth
Fernandes DM, Oliveira CR, Guerguis S, Eisenberg R, Choi J, Kim M, Abdelhemid A, Agha R, Agarwal S, Aschner JL, Avner JR, Ballance C, Bock J, Bhavsar SM, Campbell M, Clouser KN, Gesner M, Goldman DL, Hammerschlag MR, Hymes S, Howard A, Jung HJ, Kohlhoff S, Kojaoghlanian T, Lewis R, Nachman S, Naganathan S, Paintsil E, Pall H, Sy S, Wadowski S, Zirinsky E, Cabana MD, Herold BC, Consortium T. Severe Acute Respiratory Syndrome Coronavirus 2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth. The Journal Of Pediatrics 2020, 230: 23-31.e10. PMID: 33197493, PMCID: PMC7666535, DOI: 10.1016/j.jpeds.2020.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBiomarkersChildChild, PreschoolConnecticutCOVID-19C-Reactive ProteinFemaleHospitalizationHumansHypoxiaInfantIntensive Care UnitsLymphocyte CountMaleMultivariate AnalysisNew JerseyNew YorkPediatric ObesityProcalcitoninProspective StudiesRetrospective StudiesSeverity of Illness IndexSystemic Inflammatory Response SyndromeTroponinYoung AdultConceptsSARS-CoV-2 infectionRespiratory diseaseDisease severityClinical featuresAcute SARS-CoV-2 infectionGreater C-reactive proteinLow absolute lymphocyte countFuture prognostic toolAbsolute lymphocyte countTime of hospitalizationC-reactive proteinIntensive care unitSevere respiratory diseaseNon-Hispanic blacksRace/ethnicitySevere MISInflammatory syndromeLymphocyte countHospital admissionPediatric patientsCare unitMultivariable analysisProspective studyHospitalized childrenClinical management
2019
Compliance with cervical cancer screening guidelines in young female patients: rates and trends of screening in New Haven County, CT
Oliveira CR, Hosier H, Pate B, Niccolai LM, Sheth SS, Vash-Margita A. Compliance with cervical cancer screening guidelines in young female patients: rates and trends of screening in New Haven County, CT. American Journal Of Obstetrics And Gynecology 2019, 221: 530-532. PMID: 31279847, PMCID: PMC6829042, DOI: 10.1016/j.ajog.2019.07.002.Peer-Reviewed Original Research
2018
Impact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic
Deshmukh U, Oliveira CR, Griggs S, Coleman E, Avni-Singer L, Pathy S, Shapiro ED, Sheth SS. Impact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic. Vaccine 2018, 36: 3599-3605. PMID: 29759380, PMCID: PMC6314176, DOI: 10.1016/j.vaccine.2018.05.039.Peer-Reviewed Original ResearchConceptsIntervention bundleOB/GYN clinicPrevalence of womenUninsured womenVaccine uptakeAttributable reductionsMissed opportunityHPV vaccine seriesVaccine-eligible visitsVaccine-eligible womenHPV vaccine uptakeMonthly rateYoung adult womenLast study monthInterrupted time series modelHPV vaccineVaccine seriesMedical recordsHispanic womenAdult womenWhite womenStudy periodYoung adultsVaccineWomen
2017
Missed opportunities for HPV immunization among young adult women
Oliveira CR, Rock RM, Shapiro ED, Xu X, Lundsberg L, Zhang LB, Gariepy A, Illuzzi JL, Sheth SS. Missed opportunities for HPV immunization among young adult women. American Journal Of Obstetrics And Gynecology 2017, 218: 326.e1-326.e7. PMID: 29223597, PMCID: PMC5924702, DOI: 10.1016/j.ajog.2017.11.602.Peer-Reviewed Original ResearchConceptsHuman papillomavirus immunizationYoung adult womenGynecology clinicAdult womenMissed clinical opportunitiesVaccine-eligible visitsVaccine-eligible womenHuman papillomavirus vaccineMultivariable logistic regressionCross-sectional studyHospital-based obstetricsYears of ageYoung adult populationSignificant racial disparitiesUrban obstetricsPostpartum visitClinic visitsEligible womenPapillomavirus vaccinePatient characteristicsHPV immunizationHuman papillomavirusAdjusted oddsMedical recordsDifferent vaccines
2016
Influenza-like illness in an urban community of Salvador, Brazil: incidence, seasonality and risk factors
Oliveira CR, Costa GSR, Paploski IAD, Kikuti M, Kasper AM, Silva MMO, Tavares AS, Cruz JS, Queiroz TL, Lima HCAV, Calcagno J, Reis MG, Weinberger DM, Shapiro ED, Ko AI, Ribeiro GS. Influenza-like illness in an urban community of Salvador, Brazil: incidence, seasonality and risk factors. BMC Infectious Diseases 2016, 16: 125. PMID: 26975185, PMCID: PMC4791800, DOI: 10.1186/s12879-016-1456-8.Peer-Reviewed Original ResearchConceptsInfluenza-like illnessYears of ageAcute febrile illnessAnnual incidenceRisk of ILIChildren 5Year oldsIncidence of ILIMean annual incidenceEpidemiology of influenzaCommunity-based surveillanceNegative test resultsSeasonal influenza transmissionILI peakMethodsBetween 2009Febrile illnessSore throatRegression modelsDisease burdenRisk factorsSchool-aged childrenEmergency unitInfluenza transmissionSignificant burdenYoung school-age children
2015
Update on persistent symptoms associated with Lyme disease
Oliveira CR, Shapiro ED. Update on persistent symptoms associated with Lyme disease. Current Opinion In Pediatrics 2015, 27: 100-104. PMID: 25490690, PMCID: PMC4417349, DOI: 10.1097/mop.0000000000000167.Commentaries, Editorials and LettersConceptsViable B. burgdorferiLyme diseasePersistent symptomsB. burgdorferiConventional treatmentAntimicrobial treatmentCommon vector-borne illnessPersistent active infectionPersistent nonspecific symptomsVector-borne illnessConventional antimicrobial treatmentPersistent arthritisChronic symptomsNonspecific symptomsOngoing symptomsErythema migransActive infectionPersistent infectionRecent studiesSlow clearancePatientsSymptomsDiseaseNonviable organismsInfection