2024
Examining Clinical Features and Severe Neurologic Disease of Parechovirus Infection in Young Infants: A Multistate Cohort Study
Evans A, Singh S, Joshi C, Filkins L, Akkoyun E, Custodio H, Daniels E, Kao C, Richardson K, Carrillo-Marquez M, Borré C, Oliveira C, Espinosa C, Mandelia Y, Mazade M, Kimberlin D. Examining Clinical Features and Severe Neurologic Disease of Parechovirus Infection in Young Infants: A Multistate Cohort Study. Clinical Infectious Diseases 2024, ciae400. PMID: 39093815, DOI: 10.1093/cid/ciae400.Peer-Reviewed Original ResearchSevere neurological diseaseLongitudinal follow-up of infantsYoung infantsSevere diseaseViral co-infectionsNon-severe diseaseSpectrum of illnessNeurological diseasesParechovirus infectionLongitudinal follow-upPreterm gestationHPeV infectionClinical seizuresClinical featuresPoor feedingCerebral edemaHuman parechovirusCohort studyU.S. infantsCo-infectionHPeVRespiratory symptomsInfantsSevere casesDisease
2023
1747. Clinical Spectrum of a Large Multi-State U.S. Cohort of Parechovirus Infection in Neonates and Young Infants
Evans A, Filkins L, Custodio H, Daniels E, Kao C, Richardson K, Carrillo-Marquez M, Borré C, Oliveira C, Espinosa C, Bocchini J, Mandelia Y, Mazade M, Santos R, Carr S, Selvarangan R, Kimberlin D. 1747. Clinical Spectrum of a Large Multi-State U.S. Cohort of Parechovirus Infection in Neonates and Young Infants. Open Forum Infectious Diseases 2023, 10: ofad500.1578. PMCID: PMC10678563, DOI: 10.1093/ofid/ofad500.1578.Peer-Reviewed Original ResearchUniversity of Mississippi Medical CenterMulticenter clinical trialHPeV infectionStudy discontinuationClinical trialsYoung infantsMedical CenterIndustry-sponsored clinical trialsSevere HPeV infectionsMedian hospitalization durationBody fluid specimensParechovirus infectionMedian ageU.S. outbreakPediatric patientsClinical spectrumHospitalization durationFluid specimensHuman parechovirusIRB approvalReport mortalityViral testingBiochemical markersBirth historyInterim analysis