2016
Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells
Dash BC, Levi K, Schwan J, Luo J, Bartulos O, Wu H, Qiu C, Yi T, Ren Y, Campbell S, Rolle MW, Qyang Y. Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells. Stem Cell Reports 2016, 7: 19-28. PMID: 27411102, PMCID: PMC4945325, DOI: 10.1016/j.stemcr.2016.05.004.Peer-Reviewed Original ResearchConceptsVascular tissue engineeringFunctional vascular smooth muscle cellsCell-based tissueSelf-assembly approachRenewable sourcesTissue engineeringPluripotent stem cellsPlatform technologyBiomedical applicationsTissue ringsDrug screeningDisease modelingTissue model systemsHuman iPSCStem cellsBroad utilityEfficient approachLarge quantitiesEngineeringMaterials
2013
Small-Diameter Vascular Graft Engineered Using Human Embryonic Stem Cell-Derived Mesenchymal Cells
Sundaram S, Echter A, Sivarapatna A, Qiu C, Niklason L. Small-Diameter Vascular Graft Engineered Using Human Embryonic Stem Cell-Derived Mesenchymal Cells. Tissue Engineering Part A 2013, 20: 740-750. PMID: 24125588, PMCID: PMC3926168, DOI: 10.1089/ten.tea.2012.0738.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsHuman embryonic stem cell-derived mesenchymal cellsSmooth muscle cellsSMC marker expressionMesenchymal cellsEmbryonic stem cellsMarkers of cartilageLineage commitmentNew cell sourceGrowth factor betaStem cellsDifferentiation capabilityCell populationsNative counterpartsMuscle cellsHuman vessel wallStringent analysisFactor betaCell sourceCellsMarker expressionSmooth muscle actinMuscle actinVascular constructsCell sourcingEngineering a Blood-Retinal Barrier With Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Transcriptome and Functional Analysis
Peng S, Gan G, Qiu C, Zhong M, An H, Adelman RA, Rizzolo LJ. Engineering a Blood-Retinal Barrier With Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Transcriptome and Functional Analysis. Stem Cells Translational Medicine 2013, 2: 534-544. PMID: 23734062, PMCID: PMC3697821, DOI: 10.5966/sctm.2012-0134.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumBlood-retinal barrierHuman retinal pigment epitheliumPigment epitheliumHuman fetal retinal pigment epitheliumOuter blood-retinal barrierTight junctionsFetal retinal pigment epitheliumEmbryonic stem cell-derived retinal pigment epitheliumAdult retinal pigment epitheliumQuantitative reverse transcription polymerase chain reactionMaturation of hESCReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionHuman embryonic stem cell-derived retinal pigment epitheliumStem cell-derived retinal pigment epitheliumRPE replacement therapyPanel of genesReplacement therapyAnimal modelsHuman embryonic stem cellsRetinal degenerationRPE functionSerum-free mediumHuman retina