2019
Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation
Xiang Q, Yang B, Li L, Qiu B, Qiu C, Gao X, Zhou H, Min W. Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation. Journal Of Cellular And Molecular Medicine 2019, 23: 0-0. PMID: 30734494, PMCID: PMC6433861, DOI: 10.1111/jcmm.14202.Peer-Reviewed Original ResearchConceptsCardiac stem cell activationStem cell activationHuman inducible pluripotent stem cellsCardiac stem cell differentiationCSC activationStem cell differentiationInducible pluripotent stem cellsPluripotent stem cellsCardiac progenitor cellsCritical roleActivation of TNFR2Factor RNACell activationProtein Lin28Cardiomyocyte proteinsCell differentiationStem cellsProgenitor cellsStem cell-based therapiesCSC differentiationProtein expressionDifferentiationCell-based therapiesExpressionActivation
2009
Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells
Qiu C, Ma Y, Wang J, Peng S, Huang Y. Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells. Nucleic Acids Research 2009, 38: 1240-1248. PMID: 19966271, PMCID: PMC2831306, DOI: 10.1093/nar/gkp1071.Peer-Reviewed Original ResearchConceptsRNA helicase APost-transcriptional regulationHuman embryonic stem cellsEmbryonic stem cellsLin28-dependent stimulationOct4 expressionPost-transcriptional regulatory factorsPluripotency factor OCT4Subset of mRNAsPost-transcriptional levelStem cellsTarget mRNA expressionMicroRNA processingFactors OCT4Observed regulationReporter systemRegulatory factorsEfficient translationLin28Novel mechanismMRNARegulationFirst evidenceExpressionMRNA expression