2018
Suicidal thought and behavior in individuals with restless legs syndrome
Para KS, Chow CA, Nalamada K, Kakade VM, Chilakamarri P, Louis ED, Koo BB. Suicidal thought and behavior in individuals with restless legs syndrome. Sleep Medicine 2018, 54: 1-7. PMID: 30529070, DOI: 10.1016/j.sleep.2018.09.019.Peer-Reviewed Original ResearchConceptsRestless legs syndromeInternational RLS Study Group Severity ScaleLifetime suicidal ideationLifetime depression historySuicidal ideationDepression historyLegs syndromeControl participantsBrief Lifetime Depression ScaleCambridge-Hopkins RLS questionnairePotential demographic confoundersRisk of suicideStepwise logistic regressionRLS sufferersRLS questionnaireRLS diagnosisRLS severityDepression ScaleSuicidal Behaviors QuestionnaireLifetime depressionSeverity ScaleDemographic confoundersSuicidal thoughtsLogistic regressionDepressionDemoralization in Parkinson disease
Koo BB, Chow CA, Shah DR, Khan FH, Steinberg B, Derlein D, Nalamada K, Para KS, Kakade VM, Patel AS, de Figueiredo JM, Louis ED. Demoralization in Parkinson disease. Neurology 2018, 90: e1613-e1617. PMID: 29618626, PMCID: PMC5931805, DOI: 10.1212/wnl.0000000000005425.Peer-Reviewed Original ResearchConceptsDisease Rating ScaleParkinson's diseasePD cohortPatient Health Questionnaire-9 scoreOutpatient movement disorder clinicYounger ageUnified Parkinson's Disease Rating ScaleParkinson's Disease Rating ScaleMovement Disorders ClinicPart III scoreStepwise logistic regressionOverall cohortMotor dysfunctionDisorders ClinicDiagnostic criteriaTreatment approachesScale scoreLogistic regressionRating ScaleCohortControl participantsMarital statusPsychosomatic researchDepressed individualsDepression
2016
Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements
Koo BB, Blackwell T, Lee HB, Stone KL, Louis ED, Redline S, Group O. Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements. American Journal Of Geriatric Psychiatry 2016, 24: 1105-1116. PMID: 27526989, PMCID: PMC5241001, DOI: 10.1016/j.jagp.2016.04.003.Peer-Reviewed Original ResearchConceptsSevere restless legs syndromeRestless legs syndromePeriodic limb movementsDepressive symptomsLegs syndromeSleep disturbancesMild restless legs syndromeFurther adjustmentAssociation of RLSLimb movementsCardiovascular risk factorsApnea-hypopnea indexBody mass indexPotential mediatorsCross-sectional analysisEffect sizeDopaminergic medicationMass indexOsteoporotic fracturesPLMS indexDisturbed sleepRisk factorsGDS scoresPhysical activitySleep efficiency