2001
Ibuprofen as a Chemesthetic Stimulus: Evidence of a Novel Mechanism of Throat Irritation
Breslin P, Gingrich T, Green B. Ibuprofen as a Chemesthetic Stimulus: Evidence of a Novel Mechanism of Throat Irritation. Chemical Senses 2001, 26: 55-65. PMID: 11124216, DOI: 10.1093/chemse/26.1.55.Peer-Reviewed Original ResearchConceptsCapsaicin-sensitive receptorsThroat irritationRatings of irritationReceptor mechanismsSensory irritationNon-steroidal anti-inflammatory drug ibuprofenIrritationAnti-inflammatory drug ibuprofenOral irritantsThroatReceptorsNovel mechanismStimulationIbuprofenChemesthetic propertiesChemesthetic stimuliBuffering agentDrug ibuprofenPrickAgentsChemesthetic effects
1998
Temporal characteristics of capsaicin desensitization and stimulus-induced recovery in the oral cavity
Green B, Rentmeister-Bryant H. Temporal characteristics of capsaicin desensitization and stimulus-induced recovery in the oral cavity. Physiology & Behavior 1998, 65: 141-149. PMID: 9811376, DOI: 10.1016/s0031-9384(98)00162-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultCapsaicinDose-Response Relationship, DrugFemaleHumansIrritantsMaleMouthTime FactorsTongueConceptsCapsaicin desensitizationIntermittent stimulationMicroM capsaicinTopical analgesicsOral cavitySignificant desensitizationCapsaicinClinical useRecurrent stimulationDesensitizationStimulationBlock recoveryExposureMinutesRapid exposureTest stimuliStimuliTongueCandy formulationChemonociceptionAnalgesicsSecond testTreatment stimuliIrritation
1997
Perceived Irritation during Ingestion of Capsaicin or Piperine: Comparison of Trigeminal and Non-trigeminal Areas
Rentmeister-Bryant H, Green B. Perceived Irritation during Ingestion of Capsaicin or Piperine: Comparison of Trigeminal and Non-trigeminal Areas. Chemical Senses 1997, 22: 257-266. PMID: 9218138, DOI: 10.1093/chemse/22.3.257.Peer-Reviewed Original ResearchConceptsAnterior tongueIrritation ratingsIngestion of capsaicinRostro-caudal axisVagus nerveOral mucosaOropharyngeal regionPosterior tongueIntensity of sensationsChemical irritantsCapsaicinChemosensory irritationIrritationIngestionThroatIrritantsPiperineTongueChemesthetic stimuliResponsivenessPrevious findingsNerveTrigeminalMucosa
1996
Rapid recovery from capsaicin desensitization during recurrent stimulation
Green B. Rapid recovery from capsaicin desensitization during recurrent stimulation. Pain 1996, 68: 245-253. PMID: 9121811, DOI: 10.1016/s0304-3959(96)03211-3.Peer-Reviewed Original ResearchConceptsCapsaicin desensitization
1993
The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency
Green B, Shaffer G. The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency. Pain 1993, 53: 323-334. PMID: 8351161, DOI: 10.1016/0304-3959(93)90228-h.Peer-Reviewed Original ResearchConceptsInter-stimulus intervalTopical exposureIntensity of itchingUse of capsaicinApplication of capsaicinHand-held dynamometerDuration of sensitizationSensations of itchingTest 24 hFifth exposureDay 1Day 2Sensory irritationCapsaicinItchingOverall sensitivityDesensitizationLess sensitizationSensitizationSensory responsesMarked individual differencesTime courseDifferential effectsItchPungent sensationEvidence that removal of capsaicin accelerates desensitization on the tongue
Green B. Evidence that removal of capsaicin accelerates desensitization on the tongue. Neuroscience Letters 1993, 150: 44-48. PMID: 8469401, DOI: 10.1016/0304-3940(93)90104-s.Peer-Reviewed Original Research