2024
The Potential Therapeutic Effects of Botulinum Neurotoxins on Neoplastic Cells: A Comprehensive Review of In Vitro and In Vivo Studies
Safarpour D, Tavassoli F, Jabbari B. The Potential Therapeutic Effects of Botulinum Neurotoxins on Neoplastic Cells: A Comprehensive Review of In Vitro and In Vivo Studies. Toxins 2024, 16: 355. PMID: 39195765, PMCID: PMC11358967, DOI: 10.3390/toxins16080355.Peer-Reviewed Original ResearchIn vivo studiesNeoplastic cellsReview of in vitroBotulinum neurotoxinBotulinum toxinMode of deliveryAnti-neoplastic treatmentProgression of cancer cellsIn vivo deliveryAnti-neoplastic potentialIn vitro effectsPotential therapeutic effectsNon-neuronal cellsNeoplastic cell linesHigh dosesTherapeutic effectCancer cellsClostridium difficileControlled studiesApoptotic effectsCell linesDisruption of cell membranesPrimary neuronsSystematic reviewCell cytoplasmClinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter
Lefaucheur J, Moro E, Shirota Y, Ugawa Y, Grippe T, Chen R, Benninger D, Jabbari B, Attaripour S, Hallett M, Paulus W. Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter. Clinical Neurophysiology 2024, 164: 57-99. PMID: 38852434, PMCID: PMC11418354, DOI: 10.1016/j.clinph.2024.05.007.Peer-Reviewed Original ResearchTranscranial alternating current stimulationTranscranial direct current stimulationLow-intensity transcranial electrical stimulationRepetitive transcranial magnetic stimulationSpinal cord stimulationCurrent stimulationMovement disordersTreated with botulinum toxin injectionsPulse generatorTranscranial electrical stimulationBotulinum toxin injectionIdentification of musclesShort-term clinical impactDirect current stimulationDeep brain stimulationAt-home useTherapeutic neuromodulationChronic diseasesTranscranial applicationTranscranial magnetic stimulationSurgical implantation of electrodesTreatment of movement disordersFUS stimulationAxial signsNeuromodulation techniquesBotulinum Toxin Treatment, What Everyone Should Know
Jabbari B. Botulinum Toxin Treatment, What Everyone Should Know. 2024 DOI: 10.1007/978-3-031-54471-2.Peer-Reviewed Original Research
2023
Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review
Safarpour D, Jabbari B. Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review. Toxins 2023, 15: 689. PMID: 38133193, PMCID: PMC10748363, DOI: 10.3390/toxins15120689.Peer-Reviewed Original ResearchConceptsBoNT injectionsFacial sweatingCancer-related disordersParotid regionSystematic reviewComplication of parotidectomySevere jaw painBotulinum toxin treatmentParotid gland surgeryBotulinum neurotoxin therapyCessation of painSerious side effectsSite of surgeryBoNT effectsGustatory hyperhidrosisJaw painNeurotoxin therapySteroid injectionLocal resectionEsophageal strictureSurgical approachEsophageal cancerLocal injectionSaline injectionToxin treatmentTreatment of Stiff-Person Syndrome with Botulinum Toxin
Safarpour D, Jabbari B. Treatment of Stiff-Person Syndrome with Botulinum Toxin. 2023, 174-179. DOI: 10.1017/9781009105033.021.Peer-Reviewed Original ResearchBotulinum toxinStiff-person syndromeBotulinum toxin therapyToxin therapyToxin formulationsBedside guidanceInjection siteCosmetic treatmentCadaveric dissectionAnatomical landmarksSmile correctionToxinTreatmentEyesInjectionClinician's eyeLower facePathophysiologySyndromeTherapyCliniciansPhysiciansDissectionTreatment of Plantar Fasciitis/Plantar Fasciopathy with Botulinum Neurotoxins
Safarpour D, Mittal S, Jabbari B. Treatment of Plantar Fasciitis/Plantar Fasciopathy with Botulinum Neurotoxins. 2023, 269-274. DOI: 10.1017/9781009105033.034.Peer-Reviewed Original ResearchBotulinum toxinBotulinum toxin therapyPlantar FasciopathyToxin therapyToxin formulationsBedside guidanceInjection siteCosmetic treatmentCadaveric dissectionAnatomical landmarksSmile correctionBotulinum neurotoxinToxinTreatmentEyesInjectionClinician's eyeLower facePathophysiologyTherapyCliniciansPhysiciansDissection
2022
Botulinum Toxin Treatment of Pain Disorders
Jabbari B. Botulinum Toxin Treatment of Pain Disorders. 2022 DOI: 10.1007/978-3-030-99650-5.Peer-Reviewed Original ResearchBotulinum toxin treatmentPain disordersToxin treatmentPost-traumatic neuralgiaPain medicine specialistsEvidence-based literature reviewLow back painPain syndromeAnalgesic effectPain categoriesPlantar fasciitisBack painBoNT therapyTreatment menuIllustrative case historiesMedicine specialistsAnimal studiesPainDisordersTreatmentClinical chaptersLiterature reviewFasciitisNeuralgiaInternists
2020
The Yale technique of Botulinum toxin injections for Parkinson's disease and essential tremor - Customised treatment for effective and safe therapy
Mittal S, Jabbari B. The Yale technique of Botulinum toxin injections for Parkinson's disease and essential tremor - Customised treatment for effective and safe therapy. Parkinsonism & Related Disorders 2020, 79: e57. DOI: 10.1016/j.parkreldis.2020.06.220.Peer-Reviewed Original Research
2018
Botox and Other Neurotoxins
Jabbari B. Botox and Other Neurotoxins. 2018, 19-29. DOI: 10.1007/978-3-319-99945-6_3.Peer-Reviewed Original ResearchBotulinum Toxin in Restless Legs Syndrome—A Randomized Double-Blind Placebo-Controlled Crossover Study
Mittal SO, Machado D, Richardson D, Dubey D, Jabbari B. Botulinum Toxin in Restless Legs Syndrome—A Randomized Double-Blind Placebo-Controlled Crossover Study. Toxins 2018, 10: 401. PMID: 30274305, PMCID: PMC6215171, DOI: 10.3390/toxins10100401.Peer-Reviewed Original ResearchConceptsRestless legs syndromePain scoresCrossover studyLegs syndromePlacebo-controlled crossover studyDouble-blind placeboPatient Global ImpressionVisual analog scalePrevious smaller studiesCommon movement disorderQuality of lifeIncobotulinumtoxin APlacebo groupRLS symptomsAnalog scaleGlobal ImpressionOnabotulinumtoxin ALife QuestionnaireTibialis anteriorBotulinum toxinNormal salineMovement disordersRLS scoresSmall studyFemoris muscleUremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier.
Jing W, Jabbari B, Vaziri ND. Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier. American Journal Of Translational Research 2018, 10: 2137-2147. PMID: 30093950, PMCID: PMC6079125.Peer-Reviewed Original ResearchImpaired blood-brain barrierBlood-brain barrierCerebral cortexBrain barrierNF-κBBody weightChronic kidney disease (CKD) resultsInducible NO synthase isoformCentral nervous system disordersOxidative stressElevated serum ureaPro-inflammatory moleculesEndothelial junctional complexesNuclear translocationReduced body weightMale Sprague-DawleyTissue oxidative stressNervous system disordersNO synthase (NOS) isoformsCKD groupCKD ratsFibrosis mediatorsWestern blot analysisRenal functionArterial pressureBotulinum toxin in essential hand tremor - A randomized double-blind placebo-controlled study with customized injection approach
Mittal SO, Machado D, Richardson D, Dubey D, Jabbari B. Botulinum toxin in essential hand tremor - A randomized double-blind placebo-controlled study with customized injection approach. Parkinsonism & Related Disorders 2018, 56: 65-69. PMID: 29929813, DOI: 10.1016/j.parkreldis.2018.06.019.Peer-Reviewed Original ResearchConceptsHand weaknessEssential hand tremorDouble-blind placebo-controlled studyEssential tremorAdministration of onabotulinumtoxinASevere hand weaknessPlacebo-controlled studyClinical rating scoresHand tremorRating scoresParkinson's disease tremorIncobotulinumtoxinA injectionsCrossover trialPatients' perceptionsBotulinum toxinTreatment efficacyClinical practiceHand strengthForearm musclesTremor severityClinical scalesTremorWeeksTreatmentInjectionBotulinum Toxin Treatment of Movement Disorders
Safarpour Y, Jabbari B. Botulinum Toxin Treatment of Movement Disorders. Current Treatment Options In Neurology 2018, 20: 4. PMID: 29478149, DOI: 10.1007/s11940-018-0488-3.Peer-Reviewed Original ResearchTask-specific dystoniaMovement disordersHemifacial spasmBotulinum toxin treatmentMovement disorder expertsHigh-quality studiesAutonomic dysfunctionOromandibular dystoniaCervical dystoniaPain disordersBoNT therapyRest tremorLaryngeal dystoniaVocal ticsToxin treatmentTourette syndromeDystoniaDisorder expertsEssential tremorAmerican AcademyTherapeutic agentsFirst choiceEfficacyDisordersBlepharospasmBotulinum toxin treatment of pain syndromes –an evidence based review
Safarpour Y, Jabbari B. Botulinum toxin treatment of pain syndromes –an evidence based review. Toxicon 2018, 147: 120-128. PMID: 29409817, DOI: 10.1016/j.toxicon.2018.01.017.Peer-Reviewed Original ResearchConceptsLevel B evidencePain syndromeLevel of evidencePelvic painB evidenceMale pelvic pain syndromeChronic low back painTraumatic spinal cord injuryEfficacy of BoNTFemale pelvic painMale pelvic painVastus lateralis imbalanceMyofascial pain syndromePelvic pain syndromePost-herpetic neuralgiaAnterior knee painBotulinum toxin treatmentPainful knee osteoarthritisPost-operative painDifferent pain syndromesLow back painSpinal cord injuryCarpal tunnel syndromeTotal knee arthroplastyRole of BoNT
2017
Botulinum Toxin Treatment in Multiple Sclerosis—a Review
Safarpour Y, Mousavi T, Jabbari B. Botulinum Toxin Treatment in Multiple Sclerosis—a Review. Current Treatment Options In Neurology 2017, 19: 33. PMID: 28819801, DOI: 10.1007/s11940-017-0470-5.Peer-Reviewed Original ResearchNeurogenic detrusor overactivityMultiple sclerosisDetrusor muscleBoNT therapyMS-related trigeminal neuralgiaOpen-label clinical trialSymptoms of MSTreatment of MSEfficacy of BoNTLevel B evidenceBotulinum toxin treatmentInjection of BoNTBotulinum neurotoxin therapyClass IV studiesBladder detrusor muscleNon-MS populationPurpose of reviewNeurotoxin therapyDetrusor overactivityInternuclear ophthalmoplegiaOveractive bladderTonic spasmsLevel of efficacyTrigeminal neuralgiaClinical trialsThe nature, consequences, and management of neurological disorders in chronic kidney disease
Jabbari B, Vaziri ND. The nature, consequences, and management of neurological disorders in chronic kidney disease. Hemodialysis International 2017, 22: 150-160. PMID: 28799704, DOI: 10.1111/hdi.12587.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseNeurological disordersNeurological symptomsKidney diseaseImpaired blood-brain barrierDiffuse white matter diseasePeripheral neurological symptomsRestless legs syndromeCentral neurological symptomsBlood-brain barrierWhite matter diseaseCentral nervous systemReflex myoclonusNeurological complicationsPeripheral neuropathyBrain edemaCortical myoclonusHemodynamic disordersLegs syndromePeripheral originBasal gangliaBrain barrierSubcortical lesionsMovement disordersSubcortical pathologyBotulinum Toxin in Parkinson Disease Tremor A Randomized, Double-Blind, Placebo-Controlled Study With a Customized Injection Approach
Mittal SO, Machado D, Richardson D, Dubey D, Jabbari B. Botulinum Toxin in Parkinson Disease Tremor A Randomized, Double-Blind, Placebo-Controlled Study With a Customized Injection Approach. Mayo Clinic Proceedings 2017, 92: 1359-1367. PMID: 28789780, DOI: 10.1016/j.mayocp.2017.06.010.Peer-Reviewed Original ResearchConceptsDisease Rating ScaleHand weaknessPatients' perceptionsUnified Parkinson's Disease Rating ScaleParkinson's Disease Rating ScaleAdministration of onabotulinumtoxinASevere hand weaknessUse of onabotulinumtoxinAPatient Global ImpressionClinical rating scoresTreatment of tremorParkinson's disease tremorIncobotulinumtoxinA injectionsCrossover trialGlobal ImpressionGrip strengthRest tremorBotulinum toxinPD tremorPostural tremorTreatment efficacyClinical practiceSignificant improvementEssential tremorHand strengthRimabotulinumtoxinB in sialorrhea: systematic review of clinical trials
Dashtipour K, Bhidayasiri R, Chen JJ, Jabbari B, Lew M, Torres-Russotto D. RimabotulinumtoxinB in sialorrhea: systematic review of clinical trials. Journal Of Clinical Movement Disorders 2017, 4: 9. PMID: 28593050, PMCID: PMC5460542, DOI: 10.1186/s40734-017-0055-1.Peer-Reviewed Original ResearchAdverse eventsClinical trialsSystematic reviewDose-dependent adverse eventsMethodsA systematic literature reviewMild transient dysphagiaMost adverse eventsComparative clinical studyTreatment of patientsMedical literature databasesDry mouthTransient dysphagiaMild weaknessClinical studiesToxin effectsLiterature databasesBoNTIndividual studiesTrialsTreatmentPrimary publicationsDosesSystematic literature reviewSignificant benefitsReviewIncobotulinumtoxinA in Restless Legs Syndrome (RLS) – a Randomized Double Blind Cross Over Study (P3.029)
Machado D, Richardson D, Jabbari B. IncobotulinumtoxinA in Restless Legs Syndrome (RLS) – a Randomized Double Blind Cross Over Study (P3.029). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.p3.029.Peer-Reviewed Original Research
2016
Abobotulinum Toxin A in the Treatment of Chronic Low Back Pain
Machado D, Kumar A, Jabbari B. Abobotulinum Toxin A in the Treatment of Chronic Low Back Pain. Toxins 2016, 8: 374. PMID: 27983689, PMCID: PMC5198568, DOI: 10.3390/toxins8120374.Peer-Reviewed Original ResearchConceptsChronic low back painLow back painVisual analog scaleOswestry Low Back Pain Disability QuestionnaireAbobotulinum toxin ABack painQuality of lifeToxin APain Disability QuestionnairePatient Global ImpressionLevel of painPrimary outcome measureProportion of respondersStrong analgesic effectAbobotulinum toxinOswestry scorePlacebo groupAnalgesic effectDisability QuestionnaireMore patientsStudy cohortAnalog scaleGlobal ImpressionMultifactorial pathophysiologyPatients' perceptions