2024
Fetal Brain-Derived Exosomal miRNAs from Maternal Blood: Potential Diagnostic Biomarkers for Fetal Alcohol Spectrum Disorders (FASDs)
Darbinian N, Hampe M, Martirosyan D, Bajwa A, Darbinyan A, Merabova N, Tatevosian G, Goetzl L, Amini S, Selzer M. Fetal Brain-Derived Exosomal miRNAs from Maternal Blood: Potential Diagnostic Biomarkers for Fetal Alcohol Spectrum Disorders (FASDs). International Journal Of Molecular Sciences 2024, 25: 5826. PMID: 38892014, PMCID: PMC11172088, DOI: 10.3390/ijms25115826.Peer-Reviewed Original ResearchFetal alcohol spectrum disordersEffects of EtOH exposureAt-risk fetusesNon-drinking controlsFetal brain tissueVoluntary pregnancy terminationGestational ageFetal sexEtOH exposureMaternal bloodMother's serumEtOH-exposedPregnancy terminationFetal brainDrank alcoholMatched controlsPotential diagnostic biomarkersBrain-derived exosomesSonic hedgehogNeurodevelopmental disabilitiesDiagnostic biomarkersProtein levelsNeurodevelopmental disordersSpectrum disorderBrain tissue
2023
Biomarkers of Affective Dysregulation Associated with In Utero Exposure to EtOH
Darbinian N, Merabova N, Tatevosian G, Morrison M, Darbinyan A, Zhao H, Goetzl L, Selzer M. Biomarkers of Affective Dysregulation Associated with In Utero Exposure to EtOH. Cells 2023, 13: 2. PMID: 38201206, PMCID: PMC10778368, DOI: 10.3390/cells13010002.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsBrain-derived neurotrophic factorSerotonin transporter proteinEnzyme-linked immunosorbent assayEtOH exposureBDNF levelsGestational ageMaternal useSignificant upregulationFetal brainAffective dysregulationUnexposed controlsBrain monoamine pathwaysBrain-derived exosomesSerotonin reuptake inhibitorsFetal neural developmentWeeks of pregnancySERT protein levelsQuantitative reverse transcription polymerase chain reactionFetal brain samplesReverse transcription-polymerase chain reactionCaspase-3Fetal brain tissueTranscription-polymerase chain reactionDA transporter gene