2023
Navigating the Complexities of Traumatic Encephalopathy Syndrome (TES): Current State and Future Challenges
Fesharaki-Zadeh A. Navigating the Complexities of Traumatic Encephalopathy Syndrome (TES): Current State and Future Challenges. Biomedicines 2023, 11: 3158. PMID: 38137378, PMCID: PMC10740836, DOI: 10.3390/biomedicines11123158.Peer-Reviewed Original ResearchTraumatic encephalopathy syndromeChronic traumatic encephalopathyTraumatic brain injuryRepetitive head impactsEncephalopathy syndromeHeterogeneity of TBIUnique neurodegenerative diseaseEffective clinical treatmentClinical research studiesEarly diagnostic methodsClinical featuresClinical manifestationsTraumatic encephalopathyRange of treatmentsBrain injuryNeuroimaging markerClinical identificationNeurodegenerative conditionsAlzheimer's diseaseClinical treatmentClinical settingClinical researchNeurodegenerative diseasesNeuropathological phenomenaDisease
2021
A Case of Possible Chronic Traumatic Encephalopathy and Alzheimer’s Disease in an Ex-Football Player
Fesharaki-Zadeh A. A Case of Possible Chronic Traumatic Encephalopathy and Alzheimer’s Disease in an Ex-Football Player. The Neurologist 2021, 27: 249-252. PMID: 34879014, PMCID: PMC9439689, DOI: 10.1097/nrl.0000000000000391.Peer-Reviewed Original ResearchConceptsChronic traumatic encephalopathyTraumatic encephalopathyAlzheimer's diseasePrior traumatic brain injuryBehavioral variant frontotemporal dementiaRepetitive head traumaTraumatic brain injuryPrior psychiatric historyPrimary progressive aphasiaVariant frontotemporal dementiaPositron emission tomographyCTE casesClinical presentationHead traumaCase reportClinical historyDefinitive diagnosisClinical algorithmBrain injuryComorbid moodPsychiatric historyCerebrospinal fluidNeuroimaging biomarkersProgressive aphasiaFrontotemporal dementia
2020
Coronavirus disease 2019 and neurodegenerative disease: what will the future bring?
McAlpine LS, Fesharaki-Zadeh A, Spudich S. Coronavirus disease 2019 and neurodegenerative disease: what will the future bring? Current Opinion In Psychiatry 2020, 34: 177-185. PMID: 33395100, PMCID: PMC7924921, DOI: 10.1097/yco.0000000000000688.Peer-Reviewed Original ResearchConceptsCoronavirus disease 2019Multiple sclerosisParkinson's diseaseNeurodegenerative diseasesAlzheimer's diseaseDisease 2019High riskCOVID-19Heart/lung diseaseHigh-risk comorbid conditionsHospitalized COVID-19 patientsAltered mental statusCOVID-19 patientsMS patientsSuch patientsComorbid conditionsNeurological symptomsPoor outcomeLung diseaseMental statusAdvanced ageSevere diseasePatientsBetter outcomesViral infectionGene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in
Chiasseu M, Fesharaki-Zadeh A, Saito T, Saido TC, Strittmatter SM. Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in. Neurobiology Of Disease 2020, 145: 105059. PMID: 32858147, PMCID: PMC7572902, DOI: 10.1016/j.nbd.2020.105059.Peer-Reviewed Original ResearchConceptsMild traumatic brain injuryTraumatic brain injuryAlzheimer's diseaseBrain injuryGene-environment interactionsMild closed head injuryMorris water maze testAge-matched wild-type controlsStrong unmet needAccumulation of amyloidAge-matched miceClosed head injuryWater maze testNovel object recognitionPersistent cognitive deficitsProtein gene mutationsIba1 expressionWild-type controlsPhospho-tauClinical manifestationsAD pathologyAD symptomsHead injuryAD pathogenesisRisk factors