2024
A scalable and cost-efficient rRNA depletion approach to enrich RNAs for molecular biology investigations
Singh A, Xue A, Tai J, Mbadugha F, Obi P, Mascarenhas R, Tyagi A, Siena A, Chen Y. A scalable and cost-efficient rRNA depletion approach to enrich RNAs for molecular biology investigations. RNA 2024, 30: rna.079761.123. PMID: 38485192, PMCID: PMC11098455, DOI: 10.1261/rna.079761.123.Peer-Reviewed Original ResearchConceptsDepleting rRNACellular processesAbundance of rRNAMolecular biological investigationsNon-rRNA transcriptsComplex regulatory networkInvestigate gene expressionRRNA removalRRNA moleculesHistone mRNARegulatory networksSmall RNAsPositive selectionRRNARNA inputBiological investigationsTranscriptome analysisLong noncoding RNAsGene expressionRegulatory mechanismsRNAOff-target effectsNoncoding RNAsCircular RNAsTranscriptionShort peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway.
Tripathi AK, Desai PP, Tyagi A, Lampe JB, Srivastava Y, Donkor M, Jones HP, Dzyuba SV, Crossley E, Williams NS, Vishwanatha JK. Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway. J Biol Chem 2024, 300: 105680. PMID: 38272230, DOI: 10.1016/j.jbc.2024.105680.Peer-Reviewed Original ResearchPrior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters
Di Pietro C, Haberman A, Lindenbach B, Smith P, Bruscia E, Allore H, Vander Wyk B, Tyagi A, Zeiss C. Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters. Viruses 2024, 16: 246. PMID: 38400021, PMCID: PMC10891789, DOI: 10.3390/v16020246.Peer-Reviewed Original ResearchConceptsTransient gene expressionSARS-CoV-2Viral replication pathwayReplication pathwayAntiviral pathwaysEndemism patternsUpregulation of innateGene expressionQuantitative RT-PCRMitigated weight lossDual-infected animalsSARS-CoV-2 viral loadSARS-CoV-2 infectionSyrian hamstersSeasonal infection ratesSARS-CoV-2 inoculationLungs of animalsIndividual virusesSARS-CoV-2 diseaseUpper respiratory tractH1N1 infectionRT-PCRBronchoalveolar lavageViral loadCytokine levelsEditorial: The molecular basis of programmed cell death and neuroinflammation in neurodegenerative diseases.
Soni C, Tyagi A, Wang X, Mathur R. Editorial: The molecular basis of programmed cell death and neuroinflammation in neurodegenerative diseases. Front Immunol 2024, 14: 1359136. PMID: 38283364, DOI: 10.3389/fimmu.2023.1359136.Commentaries, Editorials and Letters
2023
Transcriptome analysis reveals temporally regulated genetic networks during Drosophila border cell collective migration.
Burghardt E, Rakijas J, Tyagi A, Majumder P, Olson BJSC, McDonald JA. Transcriptome analysis reveals temporally regulated genetic networks during Drosophila border cell collective migration. BMC Genomics 2023, 24: 728. PMID: 38041052, DOI: 10.1186/s12864-023-09839-8.Peer-Reviewed Original ResearchTranscriptional responses of cancer cells to heat shock-inducing stimuli involve amplification of robust HSF1 binding
Dastidar S, De Kumar B, Lauckner B, Parrello D, Perley D, Vlasenok M, Tyagi A, Koney N, Abbas A, Nechaev S. Transcriptional responses of cancer cells to heat shock-inducing stimuli involve amplification of robust HSF1 binding. Nature Communications 2023, 14: 7420. PMID: 37973875, PMCID: PMC10654513, DOI: 10.1038/s41467-023-43157-7.Peer-Reviewed Original ResearchGene loss during a transition to multicellularity.
Jiménez-Marín B, Rakijas JB, Tyagi A, Pandey A, Hanschen ER, Anderson J, Heffel MG, Platt TG, Olson BJSC. Gene loss during a transition to multicellularity. Sci Rep 2023, 13: 5268. PMID: 37002250, DOI: 10.1038/s41598-023-29742-2.Peer-Reviewed Original Research
2021
Autocrine GMCSF Signaling Contributes to Growth of HER2+ Breast Leptomeningeal CarcinomatosisGMCSF Contributes to Breast Leptomeningeal Carcinomatosis
Ansari K, Bhan A, Saotome M, Tyagi A, De Kumar B, Chen C, Takaku M, Jandial R. Autocrine GMCSF Signaling Contributes to Growth of HER2+ Breast Leptomeningeal CarcinomatosisGMCSF Contributes to Breast Leptomeningeal Carcinomatosis. Cancer Research 2021, 81: 4723-4735. PMID: 34247146, PMCID: PMC8986153, DOI: 10.1158/0008-5472.can-21-0259.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutocrine CommunicationBreast NeoplasmsCell Line, TumorCell ProliferationCell SurvivalDisease Models, AnimalGene ExpressionGranulocyte-Macrophage Colony-Stimulating FactorHumansMeningeal CarcinomatosisMiceOncogene ProteinsProtein Kinase InhibitorsReceptor, ErbB-2Signal TransductionXenograft Model Antitumor AssaysConceptsOligodendrocyte progenitor cellsLeptomeningeal carcinomatosisLC growthPan-Aurora kinase inhibitorKinase inhibitorsSuppression of HER2Growth of HER2Central nervous system cell typesProliferation of HER2Nervous system cell typesBreast cancer cellsPrimary HER2Targetable axisOminous complicationIntrathecal deliveryMolecular mechanismsTreatment optionsDire prognosisSpinal cordBreast cancerHER2LC developmentLeptomeningesLC/MS-MSCarcinomatosis
2016
High light intensity plays a major role in emergence of population level variation in Arabidopsis thaliana along an altitudinal gradient.
Tyagi A, Yadav A, Tripathi AM, Roy S. High light intensity plays a major role in emergence of population level variation in Arabidopsis thaliana along an altitudinal gradient. Sci Rep 2016, 6: 26160. PMID: 27211014, DOI: 10.1038/srep26160.Peer-Reviewed Original Research
2015
Genetic diversity and population structure of Arabidopsis thaliana along an altitudinal gradient.
Tyagi A, Singh S, Mishra P, Singh A, Tripathi AM, Jena SN, Roy S. Genetic diversity and population structure of Arabidopsis thaliana along an altitudinal gradient. AoB Plants 2015, 8 PMID: 26672075, DOI: 10.1093/aobpla/plv145.Peer-Reviewed Original Research
2013
The internal transcribed spacer (ITS) region and trnH-psbA [corrected] are suitable candidate loci for DNA barcoding of tropical tree species of India.
Tripathi AM, Tyagi A, Kumar A, Singh A, Singh S, Chaudhary LB, Roy S. The internal transcribed spacer (ITS) region and trnH-psbA [corrected] are suitable candidate loci for DNA barcoding of tropical tree species of India. PLoS One 2013, 8: e57934. PMID: 23460915, DOI: 10.1371/journal.pone.0057934.Peer-Reviewed Original Research
2010
Universal plant DNA barcode loci may not work in complex groups: a case study with Indian berberis species.
Roy S, Tyagi A, Shukla V, Kumar A, Singh UM, Chaudhary LB, Datt B, Bag SK, Singh PK, Nair NK, Husain T, Tuli R. Universal plant DNA barcode loci may not work in complex groups: a case study with Indian berberis species. PLoS One 2010, 5: e13674. PMID: 21060687, DOI: 10.1371/journal.pone.0013674.Peer-Reviewed Original ResearchOligonucleotide frequencies of barcoding loci can discriminate species across kingdoms.
Tyagi A, Bag SK, Shukla V, Roy S, Tuli R. Oligonucleotide frequencies of barcoding loci can discriminate species across kingdoms. PLoS One 2010, 5: e12330. PMID: 20808837, DOI: 10.1371/journal.pone.0012330.Peer-Reviewed Original ResearchRabies glycoprotein fused with B subunit of cholera toxin expressed in tobacco plants folds into biologically active pentameric protein.
Roy S, Tyagi A, Tiwari S, Singh A, Sawant SV, Singh PK, Tuli R. Rabies glycoprotein fused with B subunit of cholera toxin expressed in tobacco plants folds into biologically active pentameric protein. Protein Expr Purif 2010, 70: 184-90. PMID: 19818857, DOI: 10.1016/j.pep.2009.10.002.Peer-Reviewed Original Research