2024
Signs of Potential Androgen Excess Across the Lifespan in a US-based Digital Cohort Study
Wolf A, Wang Z, Onnela J, Baird D, Jukic A, Curry C, Fischer-Colbrie T, Williams M, Hauser R, Coull B, Mahalingaiah S. Signs of Potential Androgen Excess Across the Lifespan in a US-based Digital Cohort Study. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae674. PMID: 39388314, DOI: 10.1210/clinem/dgae674.Peer-Reviewed Original ResearchVitamin D Levels in the United States: Temporal Trends (2011–2018) and Contemporary Associations with Sociodemographic Characteristics (2017–2018)
Subramanian A, Burrowes H, Rumph J, Wilkerson J, Jackson C, Jukic A. Vitamin D Levels in the United States: Temporal Trends (2011–2018) and Contemporary Associations with Sociodemographic Characteristics (2017–2018). Nutrients 2024, 16: 3414. PMID: 39408379, PMCID: PMC11478591, DOI: 10.3390/nu16193414.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyNon-Hispanic black femalesVitamin D levelsNational Health and Nutrition Examination Surveys survey cyclesHealth and Nutrition Examination SurveyNon-Hispanic blacksAssociated with larger decrementsNutrition Examination SurveyMedian 25(OH)DD levelsPredictors of 25(OH)D levelsMultivariate linear regressionExamination SurveyPrevalence of 25(OH)DSurvey cyclesWeighted medianLevels of 25(OH)DSociodemographic characteristicsVitamin D supplementationFemales of reproductive ageHigher BMILow-incomeIncreased BMIMexican AmericansVitamin D data7954 Vitamin D Deficiency Underlies Defective Endometrial Decidualization In Vivo and In Vitro
Yi M, Wang T, Jukic A, DeMayo F. 7954 Vitamin D Deficiency Underlies Defective Endometrial Decidualization In Vivo and In Vitro. Journal Of The Endocrine Society 2024, 8: bvae163.1783. PMCID: PMC11454223, DOI: 10.1210/jendso/bvae163.1783.Peer-Reviewed Original ResearchVitamin D receptorVitamin D signalingVitamin DIngenuity Pathway AnalysisTreatment of 1,25(OH)<sub>2</sub>D<sub>3</sub> atDecidualization markersUterine stromal cell differentiationD signalingKnockdown of VDRUterine decidual reactionHuman endometrial stroma cellsExpression of decidualization markersVitamin D-deficient dietAbility of estrogenStromal cell differentiationD-deficient dietEndometrial stromal cellsIn vitro decidualizationEndometrial stroma cellsUpstream regulatorVitamin D receptor siRNATranscription factor vitamin D receptorResponse to exogenous hormonesB-estradiolDecidual reactionTrends in sensor-based health metrics during and after pregnancy: descriptive data from the apple women's health study
Mishra A, Park J, Shapiro I, Fisher-Colbrie T, Baird D, Suharwardy S, Zhang S, Jukic A, Curry C. Trends in sensor-based health metrics during and after pregnancy: descriptive data from the apple women's health study. AJOG Global Reports 2024, 4: 100388. PMID: 39296604, PMCID: PMC11408385, DOI: 10.1016/j.xagr.2024.100388.Peer-Reviewed Original ResearchApple Women's Health StudyWomen's Health StudyHealth metricsHealth StudyResting heart ratePre-pregnancyHeart rate variabilityBehavioral changesThird trimesterExercise minutesStep countsCardio fitnessWeeks postpartumPregnancy startHeart rateDescriptive DataPostpartumSleep durationRate variabilityWeeks of pregnancyMeasures of activityDemographic factorsTotal sleep durationObservational studyU.S. residentsPrevalence and Trends in Vitamin D Levels in the United States, 2011-2018
Subramanian A, Burrowes H, Rumph J, Wilkerson J, Jukic A. Prevalence and Trends in Vitamin D Levels in the United States, 2011-2018. Current Developments In Nutrition 2024, 8: 103800. DOI: 10.1016/j.cdnut.2024.103800.Peer-Reviewed Original ResearchVitamin D and Toxic Metals in Pregnancy - a Biological Perspective
Fisher M, Weiler H, Kuiper J, Borghese M, Buckley J, Shutt R, Ashley-Martin J, Subramanian A, Arbuckle T, Potter B, Little J, Morisset A, Jukic A. Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective. Current Epidemiology Reports 2024, 11: 153-163. PMID: 39156920, PMCID: PMC11329583, DOI: 10.1007/s40471-024-00348-0.Peer-Reviewed Original ResearchVitamin DPregnant womenHigher vitamin D statusToxic metalsPrevention of adverse outcomesTrials of vitamin D supplementationVitamin D statusVitamin D supplementationOverall nutritional statusNutritional interventionPotential biological mechanismsPregnant populationEpidemiological studiesBlood metalsNutritional statusD statusD supplementationNorth American studiesProspective studyAdverse outcomesAbsorption of metalsPregnancyIntestinal absorptionMetal exposureEndocrine disruptionIrregular Cycles, Ovulatory Disorders, and Cardiometabolic Conditions in a US-Based Digital Cohort
Wang Z, Jukic A, Baird D, Wilcox A, Li H, Curry C, Fischer-Colbrie T, Onnela J, Williams M, Hauser R, Coull B, Mahalingaiah S. Irregular Cycles, Ovulatory Disorders, and Cardiometabolic Conditions in a US-Based Digital Cohort. JAMA Network Open 2024, 7: e249657. PMID: 38700861, PMCID: PMC11069087, DOI: 10.1001/jamanetworkopen.2024.9657.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeCardiometabolic conditionsPrevalence odds ratiosAssociated with type 2 diabetesTransient ischemic attackType 2 diabetesAssociation of polycystic ovary syndromeIrregular menstrual cyclesEstimate prevalence odds ratiosCoronary artery diseaseOvulatory disordersHeart attackHigh cholesterolPolycystic ovary syndrome statusIrregular cyclesLower body mass indexCross-sectional studyAge of consentBody mass indexLogistic regression modelsMenstrual cyclePhysical activityLifestyle factorsArtery diseaseEffect modificationMenarche and Time to Cycle Regularity Among Individuals Born Between 1950 and 2005 in the US
Wang Z, Asokan G, Onnela J, Baird D, Jukic A, Wilcox A, Curry C, Fischer-Colbrie T, Williams M, Hauser R, Coull B, Mahalingaiah S. Menarche and Time to Cycle Regularity Among Individuals Born Between 1950 and 2005 in the US. JAMA Network Open 2024, 7: e2412854. PMID: 38809557, PMCID: PMC11137638, DOI: 10.1001/jamanetworkopen.2024.12854.Peer-Reviewed Original ResearchConceptsBody mass indexAdverse health outcomesEarly menarcheHealth outcomesSocioeconomic statusBirth yearCohort studyAssociated with adverse health outcomesNon-Hispanic blacksEarly-life characteristicsParticipants self-ratedEthnic minority groupsTemporal trendsSociodemographic factorsExploratory mediation analysisMain OutcomesUS cohortLate menarcheMass indexCycle regularitySelf-ratingsMenarcheHealth implicationsMediation analysisParticipantsVitamin D status and supplementation, calcium supplementation, and timing of natural menopause
Jukic A, Sandler D, Weinberg C, O'Brien K. Vitamin D status and supplementation, calcium supplementation, and timing of natural menopause. Maturitas 2024, 182: 107916. PMID: 38266360, PMCID: PMC11000149, DOI: 10.1016/j.maturitas.2024.107916.Peer-Reviewed Original ResearchConceptsCalcium supplement useTiming of natural menopauseVitamin D statusTime of menopauseNatural menopauseFollow-upVitamin DSupplement useD statusMenstrual periodAssociated with timing of menopauseHazard ratioMultivariate Cox proportional hazards modelAssociated with ovarian reserveVitamin D supplement useYears of follow-upVitamin D supplementationLoss to follow-upCox proportional hazards modelsFollow-up time pointsYear follow-upBody mass indexConfidence intervalsSister Study cohortEstimate hazard ratios
2023
Association between serum 25-hydroxyvitamin D and antimüllerian hormone levels in a cohort of African-American women
Subramanian A, Harmon Q, Bernardi L, Carnethon M, Marsh E, Baird D, Jukic A. Association between serum 25-hydroxyvitamin D and antimüllerian hormone levels in a cohort of African-American women. Fertility And Sterility 2023, 121: 642-650. PMID: 38145700, PMCID: PMC10978232, DOI: 10.1016/j.fertnstert.2023.12.023.Peer-Reviewed Original ResearchHigher AMH levelsLower AMH levelsAMH levelsAfrican American womenHigher oddsMAIN OUTCOMELower oddsAntimüllerian hormone levelsSerum AMH levelsPolycystic ovary syndromeHormonal contraceptive useBody mass indexTime of enrollmentCross-sectional studyExclusion of participantsClinical trial designAntimüllerian hormoneOvarian reserveOvary syndromeProspective cohortMass indexPrior diagnosisD levelsHormone levelsContraceptive useRacial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts
Welch B, Keil A, Buckley J, Engel S, James-Todd T, Zota A, Alshawabkeh A, Barrett E, Bloom M, Bush N, Cordero J, Dabelea D, Eskenazi B, Lanphear B, Padmanabhan V, Sathyanarayana S, Swan S, Aalborg J, Baird D, Binder A, Bradman A, Braun J, Calafat A, Cantonwine D, Christenbury K, Factor-Litvak P, Harley K, Hauser R, Herbstman J, Hertz-Picciotto I, Holland N, Jukic A, McElrath T, Meeker J, Messerlian C, Michels K, Newman R, Nguyen R, O’Brien K, Rauh V, Redmon B, Rich D, Rosen E, Schmidt R, Sparks A, Starling A, Wang C, Watkins D, Weinberg C, Weinberger B, Wenzel A, Wilcox A, Yolton K, Zhang Y, Ferguson K. Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts. Environmental Health Perspectives 2023, 131: 127015. PMID: 38117586, PMCID: PMC10732302, DOI: 10.1289/ehp12831.Peer-Reviewed Original ResearchConceptsPhthalate metabolite concentrationsPreterm birthPhthalate exposurePhthalate metabolitesEthnic disparitiesU.S. cohortHypothetical interventionUrinary phthalate metabolite concentrationsMetabolite concentrationsWhite participantsUrinary phthalate metabolitesCovariate-adjusted differencesLatina participantsExposure-response modelPooled studiesOdds ratioPacific Islander participantsAsian/Pacific Islander participantsLogistic regressionMetabolite levelsBirthPregnancyPositive associationInterventionCohortSeasonal variations of menstrual cycle length in a large, US-based, digital cohort
Li H, Curry C, Fischer-Colbrie T, Onnela J, Williams M, Hauser R, Coull B, Jukic A, Mahalingaiah S. Seasonal variations of menstrual cycle length in a large, US-based, digital cohort. International Journal Of Hygiene And Environmental Health 2023, 256: 114308. PMID: 38103472, PMCID: PMC10872302, DOI: 10.1016/j.ijheh.2023.114308.Peer-Reviewed Original Research
2017
Measurement of Vitamin D for Epidemiologic and Clinical Research: Shining Light on a Complex Decision
Jukic AMZ, Hoofnagle AN, Lutsey PL. Measurement of Vitamin D for Epidemiologic and Clinical Research: Shining Light on a Complex Decision. American Journal Of Epidemiology 2017, 187: 879-890. PMID: 29020155, PMCID: PMC5889008, DOI: 10.1093/aje/kwx297.Peer-Reviewed Original ResearchConceptsVitamin D statusVitamin DD statusIndividual's vitamin D statusFat-soluble vitaminsCardiovascular diseaseEpidemiologic studiesHealth outcomesReproductive functionIdeal interventionClinical researchDietary supplementsAvailable supplementsBiomarkersImportant considerationNew research studiesLow levelsSupplementsDate synthesisStatusEpidemiologicCancerInfectionDiseaseDramatic increase
2016
Long-term Recall of Time to Pregnancy
Jukic AM, McConnaughey DR, Weinberg CR, Wilcox AJ, Baird DD. Long-term Recall of Time to Pregnancy. Epidemiology 2016, 27: 705-711. PMID: 27487038, PMCID: PMC5444084, DOI: 10.1097/ede.0000000000000506.Peer-Reviewed Original ResearchConceptsPositive predictive valuePregnancy attemptsPregnancy dataProspective timeNorth Carolina Early Pregnancy StudyPredictive valueEarly Pregnancy StudyLifetime reproductive historiesWeighted kappa statisticHigher gravidityProspective dataRisk factorsChronic diseasesPregnancy StudyPregnancySmall studyReproductive historyLower likelihoodWomenKappa statisticsLong-term recallFuture studiesLower proportionGravidityWidespread useIncreasing serum 25-hydroxyvitamin D is associated with reduced odds of long menstrual cycles in a cross-sectional study of African American women
Jukic AM, Upson K, Harmon QE, Baird DD. Increasing serum 25-hydroxyvitamin D is associated with reduced odds of long menstrual cycles in a cross-sectional study of African American women. Fertility And Sterility 2016, 106: 172-179.e2. PMID: 26997249, PMCID: PMC4930882, DOI: 10.1016/j.fertnstert.2016.03.004.Peer-Reviewed Original ResearchConceptsMenstrual cycle lengthLong menstrual cyclesCross-sectional studyMenstrual cycleAfrican American womenCycle lengthSelf-reported menstrual cycle lengthVitamin D statusPolytomous logistic regressionAmerican womenD statusGynecologic historyOvarian hormonesProspective studyOvarian functionReduced oddsMAIN OUTCOMEIrregular cyclesLogistic regressionWomenOddsFurther investigationDaysAssociationMedicationsImpact of female age and nulligravidity on fecundity in an older reproductive age cohort
Steiner AZ, Jukic AM. Impact of female age and nulligravidity on fecundity in an older reproductive age cohort. Fertility And Sterility 2016, 105: 1584-1588.e1. PMID: 26953733, PMCID: PMC4893975, DOI: 10.1016/j.fertnstert.2016.02.028.Peer-Reviewed Original Research
2015
Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss
Jukic AM, Calafat AM, McConnaughey DR, Longnecker MP, Hoppin JA, Weinberg CR, Wilcox AJ, Baird DD, Calafat A, McConnaughey D, Longnecker M, Hoppin J, Weinberg C, Wilcox A, Baird D. Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss. Environmental Health Perspectives 2015, 124: 321-328. PMID: 26161573, PMCID: PMC4786975, DOI: 10.1289/ehp.1408164.Peer-Reviewed Original ResearchConceptsEarly pregnancy lossLuteal phase lengthShort luteal phaseFollicular phase lengthPregnancy lossMonocarboxyoctyl phthalatePhthalate metabolitesLuteal phaseMenstrual cycleDaily first-morning urine specimensFirst morning urine specimensUrinary bisphenol AFuture human studiesHuman chorionic gonadotropinVaginal bleedingDEHP metabolitesUrinary concentrationsHuman ovulationProgesterone metabolitesChorionic gonadotropinUrine specimensDetrimental alterationsHuman studiesAnimal studiesPregnancyLower plasma 25-hydroxyvitamin D is associated with irregular menstrual cycles in a cross-sectional study
Jukic AM, Steiner AZ, Baird DD. Lower plasma 25-hydroxyvitamin D is associated with irregular menstrual cycles in a cross-sectional study. Reproductive Biology And Endocrinology 2015, 13: 20. PMID: 25879830, PMCID: PMC4359493, DOI: 10.1186/s12958-015-0012-5.Peer-Reviewed Original ResearchConceptsIrregular cyclesUsual cycle lengthMenstrual cycle characteristicsUterine Fibroid StudyAge of menarcheCurrent smokingGynecologic historyHormonal contraceptionVitamin DMenstrual cyclePhysical activityBlood samplesCycle disturbancesHealth plansTelephone interviewsAlcohol usePlasma samplesWomenHuman dataCycle lengthAgeLow levelsCycle characteristicsMedicationsMethodsWomen
2014
The impact of systematic errors on gestational age estimation
Jukic AM. The impact of systematic errors on gestational age estimation. BJOG An International Journal Of Obstetrics & Gynaecology 2014, 122: 842-842. PMID: 25377244, DOI: 10.1111/1471-0528.13169.Peer-Reviewed Original Research
2013
Length of human pregnancy and contributors to its natural variation
Jukic AM, Baird DD, Weinberg CR, McConnaughey DR, Wilcox AJ. Length of human pregnancy and contributors to its natural variation. Human Reproduction 2013, 28: 2848-2855. PMID: 23922246, PMCID: PMC3777570, DOI: 10.1093/humrep/det297.Peer-Reviewed Original ResearchConceptsLast menstrual periodLength of gestationGestational lengthPreterm birthGestational ageHuman pregnancyPregnancy lengthProspective cohort studySimilar gestational ageKaplan-Meier curvesBody mass indexSingleton live birthsEarly Pregnancy StudyPARTICIPANTS/MATERIALSUrinary hormone measurementsProportional hazards modelTiming of deliveryROLE OF CHANCEIntramural Research ProgramDate of conceptionCohort studySingleton pregnanciesMass indexMedian timeAlcohol intake