2020
Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis
Eisenstein A, Chitalia S, Ravid K. Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis. International Journal Of Molecular Sciences 2020, 21: 7470. PMID: 33050467, PMCID: PMC7589187, DOI: 10.3390/ijms21207470.Peer-Reviewed Original ResearchConceptsBone healthBone marrowPotential therapeutic targetInhibitory receptorsMetabolic disturbancesReceptor effectsTherapeutic implicationsTherapeutic targetMetabolic diseasesEndogenous ligandDichotomous effectsReceptorsMarrowAdenosineAdipogenesisExpression profilesCellular stressHealthOsteogenesisCurrent understandingDifferent tissuesObesityInflammationDisease
2014
An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*
Eisenstein A, Carroll S, Johnston-Cox H, Farb M, Gokce N, Ravid K. An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*. Journal Of Biological Chemistry 2014, 289: 21071-21081. PMID: 24928509, PMCID: PMC4110311, DOI: 10.1074/jbc.m114.566406.Peer-Reviewed Original ResearchConceptsKruppel-like factor 4Regulator of stem cell maintenanceRegulator of adipocyte differentiationStem cell maintenanceInhibit differentiationRegulator of adipogenesisAdenosine receptorsKnockdown of KLF4Adipose tissue of obese subjectsAdipose tissue developmentExtracellular ligandsA2B adenosine receptorsKruppel-like factor 4 expressionCell maintenanceExpression of Kruppel-like factor 4Signaling cascadesSignaling moleculesAdipocyte differentiationAdipose biologyStromal vascular cellsTissue developmentAdipocyte progenitorsInhibit adipogenesisObese subjectsA2bAR activation
2013
G Protein‐Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors
Eisenstein A, Ravid K. G Protein‐Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors. Journal Of Cellular Physiology 2013, 229: 414-421. PMID: 24114647, PMCID: PMC4362544, DOI: 10.1002/jcp.24473.Peer-Reviewed Original ResearchMeSH KeywordsAdipogenesisAdipose TissueAnimalsGene Expression RegulationHumansReceptors, Purinergic P1ConceptsG protein-coupled receptorsAdenosine receptorsExtracellular signalsAdenosine signalingObesity epidemicMetabolic consequencesDevelopment of therapeuticsBlood flowDownstream messengersReceptorsTranscriptional eventsAdipose tissueMature adipocytesAdipocyte differentiationCellular differentiationMetabolic homeostasisAdenosineCoupled receptorsAdipocytesPhysiological outcomesDifferentiation processExcess nutrientsRegulation functionAdipogenesisDifferentiation