2018
Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions.
Gonzalez DG, Cote CM, Patel JR, Smith CB, Zhang Y, Nickerson KM, Zhang T, Kerfoot SM, Haberman AM. Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions. The Journal Of Immunology 2018, 201: 3569-3579. PMID: 30446568, PMCID: PMC6289626, DOI: 10.4049/jimmunol.1500497.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisB-LymphocytesCell DifferentiationCell Self RenewalCells, CulturedGerminal CenterInterleukin-4InterleukinsLymphocyte ActivationMiceMice, KnockoutParacrine CommunicationProto-Oncogene Proteins c-bcl-6Receptors, Interleukin-21Signal TransductionSTAT6 Transcription FactorT-Lymphocytes, Helper-InducerConceptsIL-21IL-4B cellsIL-21RCytokine IL-21Costimulatory molecule expressionB cell folliclesIL-21 signalingGC B cell developmentNonredundant roleGerminal center B cellsMurine model systemGC B cellsMolecule expressionPhenotypic maturationB cell developmentCell expressionCytokine signalsB cell transitionCombined absenceSubsequent maturationCell migrationCell developmentHistone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis
Hatzi K, Geng H, Doane AS, Meydan C, LaRiviere R, Cardenas M, Duy C, Shen H, Vidal MNC, Baslan T, Mohammad HP, Kruger RG, Shaknovich R, Haberman AM, Inghirami G, Lowe SW, Melnick AM. Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis. Nature Immunology 2018, 20: 86-96. PMID: 30538335, PMCID: PMC6294324, DOI: 10.1038/s41590-018-0273-1.Peer-Reviewed Original Research
2014
The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers
Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A. The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers. Cell Reports 2014, 8: 1497-1508. PMID: 25176650, PMCID: PMC4163070, DOI: 10.1016/j.celrep.2014.07.059.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell MovementCytokinesDNA-Binding ProteinsGerminal CenterHistone Deacetylase 2Lymphocyte ActivationMiceMutationProtein BindingProtein Structure, TertiaryProto-Oncogene Proteins c-bcl-6Receptors, G-Protein-CoupledReceptors, LysosphingolipidSphingosine-1-Phosphate ReceptorsT-Lymphocytes, Helper-InducerConceptsInnate immune cell phenotypesGC Tfh cellsImmune cell phenotypesT helper cellsGerminal center formationB cells migrateActivated B cellsB cell migrationHelper cellsInflammatory diseasesInterfollicular zonesTranscriptional repressor functionExtrafollicular responseGerminal centersB cellsImmune systemReceptor S1PR1MiceRepression domainRD2 domainRepressor functionCell migrationCells migrateCenter formationBiochemical specificityDynamic Expression of BCL6 in Murine Conventional Dendritic Cells during In Vivo Development and Activation
Zhang TT, Liu D, Calabro S, Eisenbarth SC, Cattoretti G, Haberman AM. Dynamic Expression of BCL6 in Murine Conventional Dendritic Cells during In Vivo Development and Activation. PLOS ONE 2014, 9: e101208. PMID: 24979752, PMCID: PMC4076320, DOI: 10.1371/journal.pone.0101208.Peer-Reviewed Original ResearchConceptsProtein levelsBCL6 levelsMurine conventional dendritic cellsFollicular helper T cellsCommon DC precursorsFunction of Bcl6BCL6 protein levelsConventional dendritic cellsHelper T cellsSecondary lymphoid organsGerminal center B cellsElevated protein levelsBone marrow hematopoietic stem cellsTranscriptional repressor BCL6Marrow hematopoietic stem cellsAdjuvant inoculationCDC subsetsSplenic cDCsDendritic cellsLPS injectionDC precursorsLymphoid organsMicrobial stimuliT cellsKi-67