2019
Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches
Haberman AM, Gonzalez DG, Wong P, Zhang T, Kerfoot SM. Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches. Immunological Reviews 2019, 288: 10-27. PMID: 30874342, PMCID: PMC10234181, DOI: 10.1111/imr.12731.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell DifferentiationGerminal CenterHumansLymphocyte ActivationParacrine CommunicationSignal TransductionStromal CellsT-Lymphocytes
2018
Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions.
Gonzalez DG, Cote CM, Patel JR, Smith CB, Zhang Y, Nickerson KM, Zhang T, Kerfoot SM, Haberman AM. Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions. The Journal Of Immunology 2018, 201: 3569-3579. PMID: 30446568, PMCID: PMC6289626, DOI: 10.4049/jimmunol.1500497.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisB-LymphocytesCell DifferentiationCell Self RenewalCells, CulturedGerminal CenterInterleukin-4InterleukinsLymphocyte ActivationMiceMice, KnockoutParacrine CommunicationProto-Oncogene Proteins c-bcl-6Receptors, Interleukin-21Signal TransductionSTAT6 Transcription FactorT-Lymphocytes, Helper-InducerConceptsIL-21IL-4B cellsIL-21RCytokine IL-21Costimulatory molecule expressionB cell folliclesIL-21 signalingGC B cell developmentNonredundant roleGerminal center B cellsMurine model systemGC B cellsMolecule expressionPhenotypic maturationB cell developmentCell expressionCytokine signalsB cell transitionCombined absenceSubsequent maturationCell migrationCell development
2017
Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help
Zhang TT, Gonzalez DG, Cote CM, Kerfoot SM, Deng S, Cheng Y, Magari M, Haberman AM. Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help. ELife 2017, 6: e19552. PMID: 28498098, PMCID: PMC5429091, DOI: 10.7554/elife.19552.Peer-Reviewed Original Research
2015
Intravital imaging of hair follicle regeneration in the mouse
Pineda CM, Park S, Mesa KR, Wolfel M, Gonzalez DG, Haberman AM, Rompolas P, Greco V. Intravital imaging of hair follicle regeneration in the mouse. Nature Protocols 2015, 10: 1116-1130. PMID: 26110716, PMCID: PMC4632978, DOI: 10.1038/nprot.2015.070.Peer-Reviewed Original Research
2014
Dynamic Expression of BCL6 in Murine Conventional Dendritic Cells during In Vivo Development and Activation
Zhang TT, Liu D, Calabro S, Eisenbarth SC, Cattoretti G, Haberman AM. Dynamic Expression of BCL6 in Murine Conventional Dendritic Cells during In Vivo Development and Activation. PLOS ONE 2014, 9: e101208. PMID: 24979752, PMCID: PMC4076320, DOI: 10.1371/journal.pone.0101208.Peer-Reviewed Original ResearchConceptsProtein levelsBCL6 levelsMurine conventional dendritic cellsFollicular helper T cellsCommon DC precursorsFunction of Bcl6BCL6 protein levelsConventional dendritic cellsHelper T cellsSecondary lymphoid organsGerminal center B cellsElevated protein levelsBone marrow hematopoietic stem cellsTranscriptional repressor BCL6Marrow hematopoietic stem cellsAdjuvant inoculationCDC subsetsSplenic cDCsDendritic cellsLPS injectionDC precursorsLymphoid organsMicrobial stimuliT cellsKi-67
2011
Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone
Kerfoot SM, Yaari G, Patel JR, Johnson KL, Gonzalez DG, Kleinstein SH, Haberman AM. Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone. Immunity 2011, 34: 947-960. PMID: 21636295, PMCID: PMC3280079, DOI: 10.1016/j.immuni.2011.03.024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensB-LymphocytesCell DifferentiationCell MovementGerminal CenterMicePhenotypeT-Lymphocytes, Helper-Inducer
2010
Cellular choreography in the germinal center: new visions from in vivo imaging
Hauser AE, Kerfoot SM, Haberman AM. Cellular choreography in the germinal center: new visions from in vivo imaging. Seminars In Immunopathology 2010, 32: 239-255. PMID: 20614218, PMCID: PMC3659422, DOI: 10.1007/s00281-010-0214-z.Peer-Reviewed Original Research
2007
In vivo imaging studies shed light on germinal-centre development
Hauser AE, Shlomchik MJ, Haberman AM. In vivo imaging studies shed light on germinal-centre development. Nature Reviews Immunology 2007, 7: 499-504. PMID: 17589541, DOI: 10.1038/nri2120.Peer-Reviewed Original ResearchDefinition of Germinal-Center B Cell Migration In Vivo Reveals Predominant Intrazonal Circulation Patterns
Hauser AE, Junt T, Mempel TR, Sneddon MW, Kleinstein SH, Henrickson SE, von Andrian UH, Shlomchik MJ, Haberman AM. Definition of Germinal-Center B Cell Migration In Vivo Reveals Predominant Intrazonal Circulation Patterns. Immunity 2007, 26: 655-667. PMID: 17509908, DOI: 10.1016/j.immuni.2007.04.008.Peer-Reviewed Original Research
2000
A B-cell receptor-specific selection step governs immature to mature B cell differentiation
Levine M, Haberman A, Sant'Angelo D, Hannum L, Cancro M, Janeway C, Shlomchik M. A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 2743-2748. PMID: 10688906, PMCID: PMC16000, DOI: 10.1073/pnas.050552997.Peer-Reviewed Original ResearchConceptsImmature B cellsMature B cellsB cell receptor repertoirePositive selection eventsB cell differentiationReceptor repertoireSelection eventsCell differentiationB cellsChain pairsCell receptor repertoirePeripheral B cellsReceptor specificityTime cellsMajor forceCell fractionCellsAdaptive immune responsesRepertoireConventional B cellsAvailable repertoireSelection stepImmune responseB cell fractionsSignificant skewing