2019
In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease
Morin-Zorman S, Wysocki C, Zhu J, Li H, Zorman S, Matte-Martone C, Kisanga E, McNiff J, Jain D, Gonzalez D, Rothstein DM, Lakkis FG, Haberman A, Shlomchik WD. In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease. Blood Advances 2019, 3: 2082-2092. PMID: 31296496, PMCID: PMC6650737, DOI: 10.1182/bloodadvances.2019000227.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCD11c AntigenCell CommunicationDendritic CellsDisease Models, AnimalFluorescent Antibody TechniqueGene ExpressionGenes, ReporterGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHistocompatibility Antigens Class IImmunophenotypingLymphocyte DepletionMiceMice, TransgenicProtein BindingReceptors, Antigen, T-CellSkin DiseasesT-Lymphocyte SubsetsT-LymphocytesTransplantation, HomologousConceptsDonor dendritic cellsCD8 cellsT cellsGVHD lesionsHost diseaseCD4 cellsDendritic cellsAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationMajority of CD4Dynamics of CD4Stem cell transplantationCutaneous graftAntibody infusionCell transplantationMyeloid cellsIntravital microscopyAcute deletionMajor causeLesionsTarget tissuesCD103CD4InfusionMHCII
2014
Dynamic Expression of BCL6 in Murine Conventional Dendritic Cells during In Vivo Development and Activation
Zhang TT, Liu D, Calabro S, Eisenbarth SC, Cattoretti G, Haberman AM. Dynamic Expression of BCL6 in Murine Conventional Dendritic Cells during In Vivo Development and Activation. PLOS ONE 2014, 9: e101208. PMID: 24979752, PMCID: PMC4076320, DOI: 10.1371/journal.pone.0101208.Peer-Reviewed Original ResearchConceptsProtein levelsBCL6 levelsMurine conventional dendritic cellsFollicular helper T cellsCommon DC precursorsFunction of Bcl6BCL6 protein levelsConventional dendritic cellsHelper T cellsSecondary lymphoid organsGerminal center B cellsElevated protein levelsBone marrow hematopoietic stem cellsTranscriptional repressor BCL6Marrow hematopoietic stem cellsAdjuvant inoculationCDC subsetsSplenic cDCsDendritic cellsLPS injectionDC precursorsLymphoid organsMicrobial stimuliT cellsKi-67
2010
Differential Localization of Effector and Memory CD8 T Cell Subsets in Lymphoid Organs during Acute Viral Infection
Jung YW, Rutishauser RL, Joshi NS, Haberman AM, Kaech SM. Differential Localization of Effector and Memory CD8 T Cell Subsets in Lymphoid Organs during Acute Viral Infection. The Journal Of Immunology 2010, 185: 5315-5325. PMID: 20921525, PMCID: PMC4267692, DOI: 10.4049/jimmunol.1001948.Peer-Reviewed Original ResearchConceptsT cell zonesKiller cell lectin-like receptor G1T cellsRed pulpCell zoneViral infectionMemory CD8 T cell subsetsEffector CD8 T cellsCD8 T cell subsetsLymphocytic choriomeningitis virus infectionTranscription factor T-betT cells persistAcute viral infectionCD8 T cellsMemory T cellsT cell subsetsCytokine IL-7B lymphocyte-induced maturation protein-1Long-term survivalMaturation protein-1Receptor G1Cell subsetsLymphoid organsChemokine receptorsChemokines CCL19
2009
Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection
Lee HK, Zamora M, Linehan MM, Iijima N, Gonzalez D, Haberman A, Iwasaki A. Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection. Journal Of Experimental Medicine 2009, 206: 359-370. PMID: 19153243, PMCID: PMC2646574, DOI: 10.1084/jem.20080601.Peer-Reviewed Original ResearchConceptsResident dendritic cellsCD8 T cellsDendritic cellsHSV-1 infectionT cellsEpicutaneous infectionAntigen presentationLymph node-resident dendritic cellsHSV-specific T cellsCD4 T cell responsesNeedle injectionHerpes simplex virus 1 (HSV-1) infectionSimplex virus 1 infectionT cell primingT cell responsesVirus-1 infectionMode of infectionDC populationsCell primingVaginal infectionsImmune responseMucosal tissuesMucosal surfacesHSV-1Cell responses
1999
A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus
Chan O, Hannum L, Haberman A, Madaio M, Shlomchik M. A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus. Journal Of Experimental Medicine 1999, 189: 1639-1648. PMID: 10330443, PMCID: PMC2193634, DOI: 10.1084/jem.189.10.1639.Peer-Reviewed Original ResearchConceptsB cellsAutoantibody productionMRL/MpJ-Faslpr miceAutoreactive T cellsAntigen-presenting cellsAntibody-independent roleB cell functionFunctional B cellsExpression of diseaseSerum autoantibodiesMurine lupusLocal inflammationSystemic autoimmunitySerum antibodiesPathogenic roleAntigen presentationT cellsCellular infiltrationSurface immunoglobulinPathologic phenotypeDisease expressionCell functionMiceNovel mousePrecise role