2018
Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions.
Gonzalez DG, Cote CM, Patel JR, Smith CB, Zhang Y, Nickerson KM, Zhang T, Kerfoot SM, Haberman AM. Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions. The Journal Of Immunology 2018, 201: 3569-3579. PMID: 30446568, PMCID: PMC6289626, DOI: 10.4049/jimmunol.1500497.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisB-LymphocytesCell DifferentiationCell Self RenewalCells, CulturedGerminal CenterInterleukin-4InterleukinsLymphocyte ActivationMiceMice, KnockoutParacrine CommunicationProto-Oncogene Proteins c-bcl-6Receptors, Interleukin-21Signal TransductionSTAT6 Transcription FactorT-Lymphocytes, Helper-InducerConceptsIL-21IL-4B cellsIL-21RCytokine IL-21Costimulatory molecule expressionB cell folliclesIL-21 signalingGC B cell developmentNonredundant roleGerminal center B cellsMurine model systemGC B cellsMolecule expressionPhenotypic maturationB cell developmentCell expressionCytokine signalsB cell transitionCombined absenceSubsequent maturationCell migrationCell development
2003
Reassessing the function of immune-complex retention by follicular dendritic cells
Haberman AM, Shlomchik MJ. Reassessing the function of immune-complex retention by follicular dendritic cells. Nature Reviews Immunology 2003, 3: 757-764. PMID: 12949499, DOI: 10.1038/nri1178.Peer-Reviewed Original ResearchConceptsFollicular dendritic cellsDendritic cellsImmune complexesSurface of FDCsMemory B-cell maintenanceMemory B cell developmentB cell maintenanceGerminal center B cellsGerminal center developmentB cell proliferationAffinity maturationB cell recognitionB cellsB cell developmentPotential roleNon-specific mannerCellsClose associationMaturation